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      • Ultrastructural and Molecular Analyses of the Unique Features of Cell Division in Mycobacterium Tuberculosis and Mycobacterium Smegmatis 

        Vijay, Srinivasan (2018-04-13)
        The Mycobacterium genus contains major human pathogens, like Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. They have evolved as successful ...
      • Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis. 

        Singh, Satpal
        Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ...
      • Uncovering the Role of Mitochondrial Co-chaperones and Artificial Antioxidants in Cellular Redox Homeostasis 

        Srivastava, Shubhi (2018-02-14)
        The role of mitochondria is multidimensional and ranges in vast areas, including apoptosis, cellular response towards stress, metabolism, which is regulated by a plethora of proteins, acting together to maintain cellular ...
      • Uncovering the Role of Mitochondrial Iron-sulfur (Fe-S) Cluster Biogenesis in Human Health and Disease 

        Saha, Prasenjit Prasad (2018-09-04)
        Mitochondrial dysfunction has been implicated for a wide range of human diseases. One of the major biosynthetic processes in human mitochondria is the biogenesis of Iron-Sulfur (Fe-S) clusters which primarily involves in ...
      • Uncovering the role of NFS1 in Fe-S cluster biogenesis and in the development of Infantile mitochondrial complex II/III deficiency (IMC23D) disease progression and 2. Screening single domain antibody (VHH) against a membrane transporter 

        Namala, Gayatri Devi M
        The mitochondrion is a double membrane-bound organelle found in all eukaryotic organisms. Mitochondria are endosymbiotic, autogenous organelles referred to as “Powerhouse” of cells due to their ability to synthesize ATP ...
      • Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing 

        Melangath, Geetha (2017-11-29)
        Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ...
      • Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases 

        Roy, Nainita (2013-04-04)
        Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated ...
      • Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression 

        Samaddar, Madhuja (2018-01-28)
        Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ...
      • Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family 

        Gupta, Arvind Kumar
        Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ...
      • Understanding mRNA fate regulation by RGG motif protein, Sbp1 

        Bhatter, Nupur
        Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ...
      • Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation 

        Ghosh, Dipayan
        This study has provided new insights into the mechanistic details of NHEJ and showed that DNA sequence around the break site can be a factor in determining which proteins involved in NHEJ might be recruited with a higher ...
      • Understanding Patterns of Bird Species Distribution in the Western Ghats 

        Vijayakumar, Sneha (2018-06-23)
        Macroecology is the study of relationships between organisms and the environment at large spatial and temporal scales. This field of research examines patterns in species abundance, distribution and diversity. Understanding ...
      • Understanding Phage MU Mom Regulation and Function 

        Karambelkar, Shweta (2018-06-11)
        Mu is a temperate bacteriophage which infects Escherichia coli and several other Gram negative enteric bacteria. It is an extraordinary phage in several respects and has carved a special niche for itself both as a genetic ...
      • Understanding Rules of Assembly and Species Interactions in Mixed-species Bird Flocks 

        Bangal, Priti Pandurang
        In mixed-species bird flocks (flocks hereafter), participants vary in their degree of similarity with each other. Flock participants can gain group size (supplementary) benefits by choosing similar flock partners, or ...
      • Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression 

        Waingankar, Tejashree Pradip
        The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ...
      • Understanding the Biology of Heat Shock Protein 90 in Opportunistic Fungal Pathogens 

        Chatterjee, Sharanya
        Heat shock protein 90 is one of the most abundant and evolutionary conserved class of molecular chaperones present throughout the biological kingdom. It is a specialist chaperone as its function extends beyond protein ...
      • Understanding the Dynamic Organization of the Presequence-Translocase in Translocation of Preproteins Across Mitochondrial Inner Membrane 

        Pareek, Gautam (2018-05-08)
        Mitochondrion is an endosymbiotic organelle synthesizing ~1% of its proteome, while remaining ~99% of the proteins are encoded by the nuclear genome and translated on the cytosolic ribosome. Therefore active mitochondrial ...
      • Understanding the Functions of Nucleoid Associated Proteins in Mycobacterium tuberculosis 

        Datta, Chandreyee
        The prokaryotic genome, though lacks a membrane bound organelle for its housing, is restricted to only about 25% of the cytoplasmic space called the nucleoid. The dramatic compaction required for the genome to fit in is ...
      • Understanding the Heat Shock Response Pathway in Plasmodium Falciparum and Identification of a Novel Exported Heat Shock Protein 

        Grover, Manish (2018-02-27)
        Infections or diseases are not just stressful for the one who encounters it. The pathogens causing the same also have to deal with the hostile environment present in the host. The maintenance of physiological homeostatic ...
      • Understanding the Long-term Impact and Mechanism of Action of Endosulfan, an Organochlorine Pesticide on Fertility, Development and Growth of Mice 

        Sharma, Anju
        Endosulfan (ES) is one of the major broad-spectrum organochlorine pesticides categorized as Class II (moderately hazardous) by WHO and Class I (highly acutely toxic) by US Environment Protection Agency. Although the use ...

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