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      • Ultrastructural and Molecular Analyses of the Unique Features of Cell Division in Mycobacterium Tuberculosis and Mycobacterium Smegmatis 

        Vijay, Srinivasan (2018-04-13)
        The Mycobacterium genus contains major human pathogens, like Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. They have evolved as successful ...
      • Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis. 

        Singh, Satpal
        Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ...
      • Uncovering the Role of Mitochondrial Co-chaperones and Artificial Antioxidants in Cellular Redox Homeostasis 

        Srivastava, Shubhi (2018-02-14)
        The role of mitochondria is multidimensional and ranges in vast areas, including apoptosis, cellular response towards stress, metabolism, which is regulated by a plethora of proteins, acting together to maintain cellular ...
      • Uncovering the Role of Mitochondrial Iron-sulfur (Fe-S) Cluster Biogenesis in Human Health and Disease 

        Saha, Prasenjit Prasad (2018-09-04)
        Mitochondrial dysfunction has been implicated for a wide range of human diseases. One of the major biosynthetic processes in human mitochondria is the biogenesis of Iron-Sulfur (Fe-S) clusters which primarily involves in ...
      • Uncovering the role of NFS1 in Fe-S cluster biogenesis and in the development of Infantile mitochondrial complex II/III deficiency (IMC23D) disease progression and 2. Screening single domain antibody (VHH) against a membrane transporter 

        Namala, Gayatri Devi M
        The mitochondrion is a double membrane-bound organelle found in all eukaryotic organisms. Mitochondria are endosymbiotic, autogenous organelles referred to as “Powerhouse” of cells due to their ability to synthesize ATP ...
      • Understanding Bacterial Heterogeneity in Gene Expression Under Specific and Global Regulatory Control 

        Dutta, Rohit
        Intrinsic heterogeneity in natural bacterial populations enable them to escape sudden changes in environment and evolve. Processes like cellular crosstalk, abiotic interactors, host interactions, intracellular signalling ...
      • Understanding cholesterol homeostasis and its impact on GPCR signalling in aging 

        Asthana, Suramya
        Full text embargo One year up to July 2024 Aging is defined as the time-related deterioration of physiological functions necessary for survival of organisms. Despite significant progress in the extension of human lifespan ...
      • Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing 

        Melangath, Geetha (2017-11-29)
        Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ...
      • Understanding Heat Shock Protein 90 Biology And Exploring Its Potential As A Target Against Neglected Protozoan Diseases 

        Roy, Nainita (2013-04-04)
        Cells invest a lot of energy in order to get their proteins to fold correctly and attain functionality. It is the functional proteome of a cell that defines the ‘life of a cell’. Cells have therefore employed dedicated ...
      • Understanding in vivo Significance of Allosteric Regulation in mtHsp70s : Revealing its Implications in Parkinson's Disease Progression 

        Samaddar, Madhuja (2018-01-28)
        Mitochondria are essential eukaryotic organelles, acting as the sites for numerous crucial metabolic and signalling pathways. The biogenesis of mitochondria requires efficient targeting of several hundreds of proteins from ...
      • Understanding intramolecular signal transduction in regulated proteases of the High Temperature Requirement A family 

        Gupta, Arvind Kumar
        Protein homeostasis in all organisms is a complex process involving regulatory mechanisms that govern protein synthesis, post-translational events and degradation. The protein degradation mechanism serves multiple functions ...
      • Understanding mRNA fate regulation by RGG motif protein, Sbp1 

        Bhatter, Nupur
        Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ...
      • Understanding Nonhomologous DNA End Joining: Novel Insights Into Mechanism and Regulation 

        Ghosh, Dipayan
        This study has provided new insights into the mechanistic details of NHEJ and showed that DNA sequence around the break site can be a factor in determining which proteins involved in NHEJ might be recruited with a higher ...
      • Understanding Patterns of Bird Species Distribution in the Western Ghats 

        Vijayakumar, Sneha (2018-06-23)
        Macroecology is the study of relationships between organisms and the environment at large spatial and temporal scales. This field of research examines patterns in species abundance, distribution and diversity. Understanding ...
      • Understanding Phage MU Mom Regulation and Function 

        Karambelkar, Shweta (2018-06-11)
        Mu is a temperate bacteriophage which infects Escherichia coli and several other Gram negative enteric bacteria. It is an extraordinary phage in several respects and has carved a special niche for itself both as a genetic ...
      • Understanding protein structural excursions using residue networks and implications on biological function 

        Prabantu, Vasam Manjveekar
        The information required for a protein structure to fold into the native conformation is encoded in its sequence. Studying protein structures help to understand their biological function. Molecular interactions between ...
      • Understanding Rules of Assembly and Species Interactions in Mixed-species Bird Flocks 

        Bangal, Priti Pandurang
        In mixed-species bird flocks (flocks hereafter), participants vary in their degree of similarity with each other. Flock participants can gain group size (supplementary) benefits by choosing similar flock partners, or ...
      • Understanding structure, function, and dynamics in macromolecular complexes 

        Bheemireddy, Sneha
        In the scope of my thesis work, a concerted effort was undertaken to elucidate bi- ological functions through the lens of structural analysis, employing protein dy- namics. The role of protein dynamics in shaping and ...
      • Understanding the adaptive responses of Salmonella Typhimurium during bile stress 

        Singh, Madhulika
        Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ...
      • Understanding the anticancer potential of inhibitor of BCL2, Disarib in Oral Cancer Cells and its Toxicological Evaluation in Rodents 

        Siddiqua, Humaira
        Overexpression of BCL2 has been reported in several cancers, such as B-cell lymphomas, leukemias, colorectal adenocarcinoma, breast cancer, prostate cancer, and oral cancer, making it an excellent target for cancer treatment. ...

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