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      • Deciphering canonical and non-canonical role of splicing factor Prp16 in pathogenic yeast C. neoformans 

        Negi, Manendra Singh
        RNA splicing is a ubiquitous process during eukaryotic gene expression, where non-coding introns are removed from primary transcripts to form functional mRNA. This vital process is carried out by the spliceosome, a large ...
      • Deciphering Functions & Interactions of Fission Yeast Splicing Factor SpSlu7 Relevant to Constitutive & Alternative Splicing 

        Sen, Titash
        The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ...
      • Deciphering Hypoxic Adaptations in Cutibacterium acnes using Multi-omics Profiling and Systems Modelling 

        Pandia, Bandana
        The opportunistic skin anaerobe Cutibacterium acnes (C. acnes) contributes to skin homeostasis with its antioxidant and immunomodulatory activities. C. acnes (formerly known as Propionibacterium acnes) is an aerotolerant, ...
      • Deciphering Structure-Function Relationships in a Two-Subunit-Type GMP Synthetase by Solution NMR Spectroscopy 

        Ali, Rustam (2018-04-24)
        The guanosine monophosphate synthetase (GMPS) is a class I glutamine amidotransferase, involved in the de-novo purine nucleotide biosynthesis. The enzyme catalyzes the biochemical transformation of xantosine (XMP) into ...
      • Deciphering the biochemical and biophysical properties of the Holliday junction resolvases RuvC and RuvX from Mycobacterium smegmatis 

        Agarwal, Ankit
        Homologous recombination (HR) is a ubiquitous cellular process that occurs in all three domains of life as well as in DNA and RNA viruses. In eukaryotes, HR is critically important for homology-directed DNA repair (HDDR) ...
      • Deciphering the evolutionary ecology of snake venoms and its impact on snakebite therapy in India 

        Senji Laxme, R R
        Venom, being an adaptive trait, has propelled the expansion of snake lineages across diverse habitats, such as the biogeographically distinct Indian landscapes. Natural selection optimises the potency, composition and ...
      • Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria 

        Vashishtha, Kartika
        Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ...
      • Deciphering the function of sesaminol as an anti-obesity and anti-MAFLD molecule 

        Rajprabu, R
        Obesity and its associated metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated liver disease (MAFLD), pose significant global health challenges. ...
      • Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans 

        Sandhu, Anjali
        Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ...
      • Deciphering the mechanism behind the division of the Salmonella containing vacuole (SCV) and the immunomodulation strategy employed by Salmonella Typhimurium 

        Chopra, Umesh
        The genus Salmonella represents flagellated, Gram-negative, rod-shaped anaerobic bacteria which is a leading cause of food-borne illness and causes enteric disease in a wide range of animals. In humans and several warm-blooded ...
      • Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery 

        Chatterjee, Ritika
        Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ...
      • Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation 

        Sundararaman, Ananthalakshmy (2018-01-07)
        AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ...
      • Deciphering the role of DJ-1 homologs in alleviating carbonyl and oxidative stress in Arabidopsis thaliana 

        Kataria, Priyanka
        The present study aims to elucidate the physiological role of plant DJ-1 homologs in Arabidopsis thaliana under various abiotic stress conditions. It seeks to provide deeper insights into the diverse functions of plant ...
      • Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars. 

        Raheja, Harsha
        Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ...
      • Deciphering the Role of METTL3-Dependent m6A-epitranscriptome in Glioma Stem-like Cells 

        Visvanathan, Abhirami
        The major roadblocks in treatment for GBM are resistance to therapy and recurrence of GBM cells. Regardless of various treatment strategies, the average survival of GBM patients is poor and incidence of recurrence remains ...
      • Deciphering the role of outer membrane porins in the pathogenesis of Salmonella enterica serovar Typhimurium 

        Roy Chowdhury, Atish
        Porins are highly conserved barrel-shaped proteins bound to the bacterial outer membrane and involved in the selective transport of charged molecules across the membrane. They consist of parallel and anti-parallel β sheets ...
      • Deciphering the role of spermidine in Salmonella Typhimurium pathogenesis 

        Vijay Nair, Abhilash
        Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative, facultative anaerobic bacterium. It infects a broad range of hosts, causing symptoms such as gastroenteritis, abdominal pain, inflammatory diarrhoea ...
      • Decoding Epigenetic Regulators in Cancer: Acetylation of HIF2A by Histone Acetyltransferase 1 (HAT1) is essential for executing hypoxia response in glioma 

        Kumar, Naveen
        Gliomas are tumors of the central nervous system arising from glial cells. Based on the origin of the cell type, it can be astrocytoma, oligodendroglioma, and ependymoma. Astrocytoma is the most common type of glioma, ...
      • Decoding of Attention and Behavioral State Using Local Field Potentials 

        Surya, S P
        Visual attention has been shown to modulate perceptual behavior and neuronal activity. Early psychophysical studies on attention showed that the subjects detected a target presented at the attended location better (i.e., ...
      • Deep Mutational Scanning Analyses of Protein Stability and Function 

        Kohli, Pehu
        Protein stability is critical to understanding protein function, folding, and interactions within living organisms. It plays a key role in protein engineering, where designing stable proteins is essential for developing ...

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