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      • Deciphering Functions & Interactions of Fission Yeast Splicing Factor SpSlu7 Relevant to Constitutive & Alternative Splicing 

        Sen, Titash
        The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ...
      • Deciphering Structure-Function Relationships in a Two-Subunit-Type GMP Synthetase by Solution NMR Spectroscopy 

        Ali, Rustam (2018-04-24)
        The guanosine monophosphate synthetase (GMPS) is a class I glutamine amidotransferase, involved in the de-novo purine nucleotide biosynthesis. The enzyme catalyzes the biochemical transformation of xantosine (XMP) into ...
      • Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria 

        Vashishtha, Kartika
        Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ...
      • Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans 

        Sandhu, Anjali
        Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ...
      • Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery 

        Chatterjee, Ritika
        Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ...
      • Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation 

        Sundararaman, Ananthalakshmy (2018-01-07)
        AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ...
      • Deciphering the Role of METTL3-Dependent m6A-epitranscriptome in Glioma Stem-like Cells 

        Visvanathan, Abhirami
        The major roadblocks in treatment for GBM are resistance to therapy and recurrence of GBM cells. Regardless of various treatment strategies, the average survival of GBM patients is poor and incidence of recurrence remains ...
      • Deciphering the role of outer membrane porins in the pathogenesis of Salmonella enterica serovar Typhimurium 

        Roy Chowdhury, Atish
        Porins are highly conserved barrel-shaped proteins bound to the bacterial outer membrane and involved in the selective transport of charged molecules across the membrane. They consist of parallel and anti-parallel β sheets ...
      • Decoding Epigenetic Regulators in Cancer: Acetylation of HIF2A by Histone Acetyltransferase 1 (HAT1) is essential for executing hypoxia response in glioma 

        Kumar, Naveen
        Gliomas are tumors of the central nervous system arising from glial cells. Based on the origin of the cell type, it can be astrocytoma, oligodendroglioma, and ependymoma. Astrocytoma is the most common type of glioma, ...
      • Delineating the Role of OsMADS1 in Auxin Distribution, Floret Identity and Floret Meristem Determinacy 

        Lhaineikim, Grace (2017-12-02)
        Rice have highly derived florets borne on a short branch called ‘spikelet’ comprised of a pair of rudimentary glumes and sterile lemma (empty glumes) that subtends a single fertile floret. The floral organs consist of a ...
      • Delineating the Roles for WNT Signaling During PRRs Driven Inflammatory Responses : Implications for Host-Pathogen Interaction 

        Singh, Vikas
        The mammalian immune system consists of the innate and adaptive arm/s that protect the host against pathogenic infections in a highly coordinated process involving multiple steps. Innate immune cells such as macrophages ...
      • Delineation Of Signal Transduction Events During The Induction Of SOCS3 By Mycobacterium Bovis BCG : Possible Implications For Immune Subversion Mechanisms 

        Yeddula, Narayana (2010-09-30)
        Pathogenic Mycobacteria are among the most unrelenting pathogens known to mankind as one-third of the world population is latently infected with Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis. ...
      • Delineation Of Signaling Events Regulating Mycobacterium Bovis BCG Induced Expression Of MMR-9 And SPI6 : Possible Implications For Immune Subversion Mechanisms 

        Kapoor, Nisha (2013-08-30)
        One key to the pathogenic potential of the mycobacteria lies in their capacity to resist destruction by infected macrophages and dendritic cells. Robust host immune responses during mycobacterial infection often involve a ...
      • Delta-Aminolevulinic Acid Dehydratase From Plasmodium falciparum - Indigenous Vs Imported 

        Dhanasekaran, S (2011-05-02)
      • Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe 

        Nagampalli, Vijay Krishna (2018-05-10)
        Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene ...
      • Design and Characterization of HIV-1 ENV Derived Immunogens 

        Purwar, Mansi (2018-06-21)
        The Human Immunodeficiency Virus (HIV) is a member of the retroviridae family from lentivirus genus which primarily infects CD4+ T cells and also to lesser degree monocytes, macrophages, and dendritic cells causing progressive ...
      • Design And Isolation Of Temperature Sensitive Mutants Of Gal4 In Yeast And Drosophila 

        Mondal, Kajari (2009-04-16)
        Genomic and proteomic investigations have yielded, and continue to produce, a large amount of information about genes and their protein products. In contrast, the evidence bearing on physiological roles of specific proteins ...
      • Design and Stabilization of Stem Derived Immunogens from HA of Influenza A Viruses 

        Najar, Tariq Ahmad (2018-07-19)
        Influenza virus belongs to the Orthomyxovirus family of viruses that causes respiratory infection in humans, leading to morbidity and mortality. The mature influenza A virion has an envelope that contains two major surface ...
      • Design of Influenza Immunogens by Hemagglutinin (HA) Protein Minimization 

        Mallajosyula, V Vamsee Aditya (2018-01-31)
        Influenza virus is a pleiomorphic human pathogen which causes self-limiting respiratory illness lasting one-two weeks in most individuals. However, in immunologically compromised individuals, influenza infection may lead ...
      • Design of soluble and particulate immunogens derived from the stem of Influenza hemagglutinin 

        Kar, Uddipan
        Influenza is a highly contagious virus, belonging to the family Orthomyxoviridae that causes acute febrile respiratory illness which can be fatal in some cases. The highest risk groups for influenza viral infection ...

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