Browsing Division of Biological Sciences by Title
Now showing items 403-422 of 957
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Japanese Encephalitis Virus Infection In Vitro : Role Of Type-I Interferons And NF-kB In The Induction Of Classical And Nonclassical MHC-I Molecules
(2011-03-08)Japanese encephalitis virus (JEV) is one of the major causes of encephalitis in Asia. JEV causes serious inflammation of the brain, which may lead to permanent brain damage and has a high mortality rate. Almost 3 billion ... -
Kinetic, Catalytic and Epigenetic Properties of HpyAXVII DNA Methyltransferase – a Phasevarion in the Human Pathogen Helicobacter pylori
Helicobacter pylori is the leading cause of gastric cancer in human beings. It is a helix-shaped, Gram-negative, motile bacteria that colonizes the gastric mucosa and eventually the gastric epithelium. It has an overabundance ... -
Large Herbivore Dung Decomposition: Effects on Nutrient Cycling in a Tropical Forest of Southern India
Large herbivores can selectively feed on nutrient rich resources, resulting in regular deposition of high quality organic matter in the form of dung. In tropical forests such as in southern India it is estimated that large ... -
Large-Scale Structural Analysis of Protein-ligand Interactions : Exploring New Paradigms in Anti-Tubercular Drug Discovery
(2018-08-13)BIOLOGICAL processes are governed through specific interactions of macromolecules. The three-dimensional structural information of the macromolecules is necessary to understand the basis of molecular recognition. A large ... -
Light-And Cytokinin-Regulated Plastid And Nuclear Gene Expression In Cucumber (Cucumis Sativus L)
(Indian Institute of Science, 2005-12-06)Light and phytohormones, such as cytokinins, have been known to play a pivotal role in numerous physiological processes in plant cells. Previous work in our laboratory has revealed the light- and cytokinin- modulated changes ... -
Lineage delimitation and diversification in Nyctibatrachus, an endemic frog genus from the Western Ghats
Determining how biodiversity is produced and maintained remains one of the fundamental questions in ecology. The phenomenon of diversification, which occurs via the interplay of speciation and extinction, holds the key ... -
Lip Y, The PE Family Triacylglycerol Hydrolase From Mycobacterium Tuberculosis : Functional Role Of The PE Domain And Immunogenicity
(2010-10-28)More human lives have been lost to tuberculosis than to any other disease and despite the availability of effective short course chemotherapy (DOTS) as well as the Bacilli Calmette Guerin (BCG) vaccine, tuberculosis continues ... -
Lithium Exposure Induced Changes At Glutamatergic Synapses In Hippocampal Neurons- Insights From In Vitro Electrophysiology And Imaging Studies
(2016-11-15)Lithium is a drug used to treat mood disorders and also has many side effects, including central nervous system (CNS) complications (such as cognitive dulling), associated with its use. The mechanism of its action still ... -
Local Interactions, Spatial Patterns and Ecosystem Stability
Many ecosystems exhibit striking patterns in the spatial distribution of organisms, for example, patterns of clumping and dispersion in semi-arid vegetation, mussel in intertidal beds and even sea-grass and macroalgae. ... -
Malat1 and COP1 mediated host responses orchestrate mycobacterial pathogenesis
Tuberculosis, which is caused by Mycobacterium tuberculosis (Mtb), is viewed to be the predominant cause of death arising due to bacterial infection. Further, the emergence of MDR/XDR strains and co-infections has compounded ... -
Manganese-Dependent Serine/Threonine/Tyrosine Kinase From Arabidopsis Thaliana : Role Of Serine And Threonine Residues In The Regulation Of Kinase Activity
(2008-10-01)Protein phosphorylation is an important post-translational modification of proteins, which can either activate or inhibit the function of a given protein. The enzymes, protein kinases and protein phosphatases catalyze the ... -
Manipulating Bacterial and Host Reactive Oxygen Species (ROS)- based mechanisms to potentiate killing of Mycobacterium tuberculosis (Mtb)
Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic ... -
Map-based Cloning and Characterization of TARANI, a Global Regulator of Arabidopsis Development
(2018-03-02)Forward genetic screen was performed in Arabidopsis thaliana to isolate novel genes involved in leaf development. The tarani (tni) mutant was selected for further study based on its unique cup-shaped lamina with +ve Gaussian ... -
Mapping Of Glycoprotein Hormone-Receptor Interactions Using Hormone Analogs And Antibodies
(2010-09-21)The glycoprotein hormone family comprising of Luteinizing Hormone (LH), Chorionic Gonadotropin (hCG), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH) plays important role in reproduction and overall ... -
Mapping the Functional Domain of Glycodelin A : An Immunomodulatory Lipocalin
Glycodelins (Gds) are dimeric, glycosylated proteins belonging to the lipocalin superfamily which are primarily transporters of small hydrophobic molecules. Gd is classified under the lipocalin superfamily as it shows 55 ... -
Mass Spectrometric Deconvolution of Libraries of Natural Peptide Toxins
(2018-03-24)This thesis deals with the analysis of natural peptide libraries using mass spectrometry. In the course of the study, both ribosomal and non-ribosomal classes of peptides have been investigated. Microheterogeneity, ... -
Mass Spectrometric Sequencing Of Acyclic And Cyclic Peptides
(2009-05-18)Elucidation of the primary structure of peptides and proteins de novo by mass spectrometry (MS) has become possible with the advent of tandem MS methods. The most widely used chemical method due to Edman (Edman & Begg, ... -
Mate Choice, Mate Sampling And Baffling Behaviour In The Tree Cricket Oecanthus henryi
(2017-07-12)Among the different sensory modalities that play a role in sexual selection, acoustic communication plays an important one. Acoustic communication has been known to be used for male-male competition (territory maintenance, ... -
Maternal Immune Activation Perturbs Gene Expression in the Embryonic Brain Leading to Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) constitutes a spectrum of developmental disorders that share common phenotypes of social and communication deficits and repetitive behaviours. ASDs have many possible underlying causes ... -
Mechanism of Abrin-Induced Apoptosis and Insights into the Neutralizing Activity of mAb D6F10
(2017-11-23)Abrin is a potent toxin obtained from the seeds of Abrus precatorius. It is a heterodimeric glycoprotein consisting of an A and a B subunit linked together by a disulfide bond. The toxicity of the protein comes from the A ...