Division of Biological Sciences
Collections in this community
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Biochemistry (BC) [250]
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Department of Developmental Biology and Genetics (DDBG) [1]
Earlier known as MRDG
Recent Submissions
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Elucidating the Role of miR-617 in Oral Squamous Cell Carcinoma Pathogenesis
Oral Squamous Cell Carcinoma (OSCC) or oral cancer is the malignancy of the epithelial lining of the oral cavity. It is the leading cause of cancer-related mortality in Indian males and despite technological advancements, ... -
Investigating mechanisms underlying astrocytic involvement in depressive-like behavior and antidepressant action
Major Depressive disorder (MDD) is a complex, multifactorial psychiatric illness which affects over 20% of the population worldwide. Despite its prevalence, our understanding of its pathophysiology is severely limited, ... -
Solution NMR studies of a potent subtilisin inhibitor from Budgett’s frog and the catalytic subunit of AHAS
This thesis involves a detailed structural study of two molecular systems, a small disulfide-rich peptide LL-TIL and a large catalytic subunit of AHAS. Subtilisin inhibitors play an important role in fighting against ... -
Understanding structure, function, and dynamics in macromolecular complexes
In the scope of my thesis work, a concerted effort was undertaken to elucidate bi- ological functions through the lens of structural analysis, employing protein dy- namics. The role of protein dynamics in shaping and ... -
Metabolic and Pharmacological Modulations During IFN-γ signaling
Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ... -
Exploring the Marine Algicolous Endophytic Fungi: A Promising Source of Novel Cancer Therapeutics
Cancer is the second leading cause of mortality globally, with over 6 million new cases diagnosed annually. Research on effective therapies is crucial due to the disease's complexity. Natural materials in chemotherapy have ... -
Conformational Heterogeneity, Solution Structure and Autoregulatory Roles of the MazE9 Antitoxin from Mycobacterium tuberculosis
The work presented in this thesis endeavors to decode the details of the dynamics of MazE9 antitoxin of the Mycobacterium tuberculosis MazEF9 toxin-antitoxin system and the transcriptional autoregulation effected by it. ... -
In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia
Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ... -
Risks of finding mates in the wild: Ecological and Behavioural Determinants of Sex-biased Predation
Sex-biased predation occurs when one sex of a prey species is consumed more than the other, irrespective of their relative availability (sex-ratio). Some of the potential factors leading to sex- biased predation are sex ... -
Decoding of Attention and Behavioral State Using Local Field Potentials
Visual attention has been shown to modulate perceptual behavior and neuronal activity. Early psychophysical studies on attention showed that the subjects detected a target presented at the attended location better (i.e., ... -
Algorithms for Investigating, Decoding and Designing ligand recognition sites in proteins - A Structural Bioinformatics Approach to Studying Protein Function
All physical processes in living organisms are driven by specific biomolecular interactions. Elucidating the characteristics of biomolecular interactions between proteins and their respective small molecule ligands can ... -
Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis
Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ... -
On mechanisms and conformational dynamics of Drug:H+ Antiporters
Multidrug efflux is an active transport process involving energy consumption to drive antibacterial compounds out of cells. This is performed either through primary active transport, where chemical energy, such as hydrolysis ... -
Translation in the 3'Untranslated Region of Mammalian Transcripts
Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the untranslated region of the mRNA. However, there are certain instances ... -
Role of 3D-organization of the X-inactivation centre in imprinted X-chromosome inactivation
The connection between 3D-genome organization and genome regulation is one of the fundamental questions in modern biology. In a nucleus, the genome is organized through different layers of 3D-organization such as ... -
miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of CVB3 infection-induced cell death ... -
The Nse1p RING domain is required for maintaining transcriptional silencing and genomic organization in Saccharomyces cerevisiae
Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ... -
Characterization of Visual Stimulus-Induced Gamma Oscillations as Signatures of Mechanisms Underlying Healthy Aging and Disease
Neural oscillations are rhythmic fluctuations in the electrical activity recorded from the brain that convey important information about brain function. Gamma oscillations, which refer to the 30–80 Hz frequency range, are ... -
Peritoneal colonization of ovarian cancer
The primary cause of mortality associated with cancer is metastasis, i.e., the spread of transformed cells from the site of oncogenesis to secondary loci within the body. Epithelial ovarian cancer (EOC) is a debilitating ... -
Translation in Erythroid cells
Erythrocytes are specialized cells that perform the crucial function of gas exchange in all vertebrates. Regulation of gene expression was believed to be absent in these cells due to the absence of nucleus. It was also ...