• Investigating DJ-1 homologs in maintaining genome integrity through glycation repair of macromolecules: Implications in regulating mitochondrial health 

  Susarla, Gautam Ratna Kiran

  The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ...

• Impact of low-dose radiation in inducing mitochondria dependent inflammaging - A new model for cellular senescence 

  Mathew, Abraham Binoy

  Recent advances in the field of aging have identified cellular senescence as one of the major hallmarks of aging and the accumulation of senescent cells in a biological system is associated with inflammation and many age ...

• Investigation of the stress-induced translatome of matrix-deprived cancer cells 

  Warrier, Shweta

  Cancer remains one of the leading causes of death worldwide, in spite of all the ongoing research in the field of oncology. While there have been some breakthroughs in the past 50 years, metastatic tumors remain the bane ...

• Hominini-specific regulation of cell cycle by stop codon readthrough of FEM1B 

  Akhtar, Md Noor

  In certain mRNAs ribosomes continue translation beyond the canonical stop codon to generate longer isoform with a C-terminal extension. This phenomenon is termed stop codon readthrough (SCR). Previously, a genome-wide ...

• Structural characterization of Staphylococcal γ-hemolysin in the presence of a lipid environment using single particle cryo-EM 

  Mishra, Suman

  γ-Hemolysin (γ-HL) is a quintessential bicomponent β-pore forming toxin (β-PFT) belonging to the arsenal of “superbug” Staphylococcus aureus. Here, we performed negative staining-TEM and single particle cryo-EM-based ...

• Integrative multiscale modeling and simulations of biomolecules with experimentally testable predictions 

  Baratam, Krishnakanth

  This thesis delves into four separate research works related to Integrative multiscale modeling and simulations of biomolecules. The first work deals with the puzzling case of the Pleckstrin Homology Domain (PHD), which ...

• Unraveling the role of cellular phosphatases in lysosome function and storage diseases 

  Kumari, Darpan

  Investigating the role of DUSP14 and Rab7A in endo-lysosomal trafficking in mammalian cells Eukaryotic cells maintain homeostasis and interact with their environment through intricate metabolic processes, including the ...

• Role of RTEL1 helicase in the regulation of homologous recombination during DNA replication 

  Dixit, Suruchi Dayanand

  Homologous recombination (HR) plays an essential role in the repair of DNA double-strand breaks (DSBs), replication stress responses, and genome maintenance. Although the mechanism of HR has been extensively studied in the ...

• Unravelling Crosstalk in Two-component Signalling Systems and Its Role in Mycobacterium Species 

  Singh, Devendra Pratap

  A typical two-component signaling system (TCSs) is composed of two transcriptionally coupled proteins (cognate pair) where one is a signal-sensing histidine kinase (HK) and the other, an output-generating response regulator ...

• Elucidation of the structure-function relationship of the Saccharomyces cerevisiae HORMA domain-containing proteins Hop1 and Rev7 

  Dhyani, Kshitizia Mohan

  DNA-based transactions like replication, repair, recombination and transcription are central to survival, inheritance and evolution. Not surprisingly, these mechanisms are tightly regulated by a myriad of protein-protein, ...

• Studies on the mechanisms of action and the physiological roles of MutT1 in mycobacteria 

  Emam, Elhassan Ali Fathi

  Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, thrives and proliferates inside host macrophages, encountering a high level of reactive oxygen species and reactive nitrogen intermediates which is generated by the ...

• Design of Nanoparticle-based Immunogens for Influenza and SARS-CoV-2 

  Khaleeq, Sara

  Embargo up to 5/9/2025

• Deciphering the role of spermidine in Salmonella Typhimurium pathogenesis 

  Vijay Nair, Abhilash

  Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative, facultative anaerobic bacterium. It infects a broad range of hosts, causing symptoms such as gastroenteritis, abdominal pain, inflammatory diarrhoea ...

• Deciphering the evolutionary ecology of snake venoms and its impact on snakebite therapy in India 

  Senji Laxme, R R

  Venom, being an adaptive trait, has propelled the expansion of snake lineages across diverse habitats, such as the biogeographically distinct Indian landscapes. Natural selection optimises the potency, composition and ...

• Electrophysiological studies investigating drug effects on hHCN1 channels and Unravelling pore dynamics in Pannexin channels 

  Bhalchandra, Apotikar Ashish

  Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel stands out for its unique characteristics, including sensitivity to transmembrane voltage and cyclic nucleotides, as well as its non-selective passage ...

• Characterization of a Staphylococcus aureus multi-enzyme complex involved in the phenotypic switch and host-pathogen interactions 

  Muralidharan, Vandanashree

  RNA homeostasis is maintained by synchronizing RNA synthesis and RNA degradation. These processes are synchronized to growth conditions and environmental stimuli, thus enabling bacterial survival in diverse environmental ...

• Design and characterization of stabilized mutants of the SARS-CoV-2 Receptor Binding Domain 

  Khan, Mohammad Suhail

  The global pandemic caused by SARS-CoV-2 has resulted in millions of deaths worldwide, highlighting the urgent need for effective vaccines. The trimeric spike glycoprotein, particularly the receptor-binding domain (RBD), ...

• How does familiarity change visual object representations ? 

  Das, Jhilik

  Familiarity with something implies having a close acquaintance with that item, generally acquired over a period of time. Apart from single items, we have experienced getting familiar with a pair of items (like a mouse and ...

• Studies on the translation initiation factors in bacteria and mitochondria 

  Singh, Jitendra

  The process of protein synthesis is a fundamental and key event in living organisms. The process of translation initiation is assisted by specific proteins known as initiation factors. In bacteria, three initiation ...

• Investigating the maintenance of X- chromosome inactivation in extra-embryonic endoderm and epiblast stem cells 

  Arava, Maniteja

  In eutherian female mammals, one of the X-chromosomes gets inactivated to compensate for the expression dosage of X-linked genes between the sexes. X-chromosome inactivation (XCI) serves as a paradigm of epigenetic memory ...

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