Division of Biological Sciences
Recent Submissions
-
Studies on the roles of Lon protease and its substrates during antibiotic resistance in Escherichia coli: modulatory effects of nitroaromatics and nitrofurantoin
Bacteria adapt to environmental stresses, including antibiotic stress, by regulating various genes and metabolic pathways. In prokaryotes, the energy-dependent protein degradation is controlled primarily by two ... -
Patterns and drivers of elevational migration in Himalayan birds
Migration is a behavioural strategy that species use to deal with seasonal variation in climate and resources. A common form of migration is elevational migration, which is a short-distance movement undertaken by mountain ... -
Decoding determinants of selectivity in biomolecules
Molecular events demonstrate remarkable specificity amid complexity in its cellular environment. This phenomenon, termed biomolecular recognition, is fundamental to the organization and regulation of biological systems. ... -
PSD95 as a biophysical modulator of synaptic communication
PSD95 is a core scaffold protein of the postsynaptic density (PSD) at excitatory synapses and a member of the MAGUK family, where it plays a central role in organizing glutamate receptors, ion channels, and signalling ... -
Importance of formylation in eubacterial translation initiation
Initiation of protein synthesis in all organisms occurs with the amino acid methionine. In the case of eubacteria and eukaryotic organelles, methionine is further modified to formylmethionine by the enzyme methionyl?tRNA ... -
Role of Queuosine in Codon-Anticodon Interaction
The speed and accuracy of the process of protein synthesis is very high. The major step at which the fidelity of translation is governed is at the step of codon?anticodon pairing. An erroneous codon?anticodon pairing can ... -
Purification and characterization of DNA-dependent RNA polymerase II from candida utilis
Abstract not available -
Molecular characterisation of Saccharomyces cerevisiae Prp17protein and its interacting partners
In majority of eukaryotic genes, removal of intervening sequences from pre?mRNA is essential for its expression. A ribonucleoprotein complex called the spliceosome catalyses the removal of intron by two sequential ... -
Genome-wide and structural analyses of signalling proteins with special reference to protein kinases
The work done in the dissertation involves genome?wide sequence analysis on the Plasmodium falciparum proteins with a broad objective of understanding further the functional diversity and evolution. P. falciparum is one ... -
X-ray crystallographic studies of amino acid-carboxylic acid complexes
The structure, assembly and action of proteins critically depend upon non?covalent interactions. A programme aimed at elucidating the atomic details of such interactions using an approach involving the preparation and X?ray ... -
Exploration of some components of fatty acid biosynthesis in prokaryotes and eukaryotes : PANK of homo sapiens and fabl of plasmodium falciparum
Coenzyme A (CoA) is a central molecule that plays a key role in this process. In the course of this project, we have attempted to address some key questions that deal with an enzyme involved in CoA biosynthesis (Pantothenate ... -
Studies on thermo-resistant bacilli
A beginning was made in this country in the systematic study of spore‑forming bacteria capable of growing at 55°C. Ninety‑five odd isolates were obtained from sources such as soils, water from hot springs, air, dust, and ... -
Ecologically sound integrated regional energy planning
The central theme of the integrated energy plan would be to prepare an area-based decentralised energy plan to meet energy needs for subsistence and development of alternate energy sources at least cost to the economy and ... -
Antifungal antibiotics by actinomycetes formation of champamycin - B By Streptomyces Champavatii
Presently, the chemotherapeutic treatment of the widely prevalent fungal infections in humans, animals and plants is far from satisfactory and is in marked contrast to that of bacterial diseases which are controlled successfully ... -
Design of a thermostable pan-sarbecovirus vaccine
Coronaviruses (CoVs) are a global health threat due to their potential for widespread transmission including in humans. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent responsible for ... -
Characterizing the role of claudins in C. elegans neurons
Cell adhesion molecules (CAMs) play important roles in neurons, contributing to nervous system development, synapse formation and plasticity. A subset of CAMs, Claudins, known for their roles at tight junctions, remain ... -
Understanding the physiological role of ITPK1-type inositol phosphate kinase in embryophytes
Land plants have evolved sophisticated mechanisms to adapt to phosphate (Pi) limitation, yet such regulatory networks in nonvascular bryophytes remain poorly understood. Here, we show that both male and female liverworts ... -
Structure andinteractions of polyamines
Polyamines are ubiquitous biological cations. Their high concentration in cells, increase in rapidly growing tissues and the regulatory mechanisms that have evolved for controlling them, point to the importance of polyamines ...
RSS 1.0