Division of Biological Sciences
Recent Submissions
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Cyclic nucleotide-binding proteins in mycobacteria
Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ... -
Elucidating the diverse functions of RGG-motif containing proteins
One year embargo upto 20/2/2026 RGG-motif containing proteins represent one of the major subsets of RNA-binding proteins characterized by the presence of RGG/RG repeats. These proteins have been associated with a wide ... -
Interaction of the TCP4 protein with other transcription factors and its effect on Arabidopsis shoot apex
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) class of proteins are plant-specific transcription factors with a non-canonical basic helix-loop-helix (bHLH) domain involved in both DNA-binding and ... -
Role of HCN Currents (Ih) in Epileptiform Activity in Subicular Neurons
Subicular burst firing neurons are established as primary instigators of seizure onset and propagation in Temporal Lobe Epilepsy (TLE), a form of focal epilepsy that accounts for approximately 60% of all epilepsy cases in ... -
Theta modulated dynamics in the hippocampus and its inputs during spatial navigation
The hippocampus is crucial for spatial navigation and has been hypothesized to integrate sensory information and mnemonic cues about items and experiences within a spatial context to create memories. Area CA1 is the ... -
Characterizing the link between dynamics and function in proteins that violate the structure-function paradigm
The structure-function paradigm states that the three-dimensional structure of a protein is dictated by its amino acid sequence, which influences its function. However, this paradigm fails to explain the behaviour of ... -
Exploring the roles of nucleoid-associated protein HU and two of its interacting proteins in Mycobacterium tuberculosis pathogenesis
Embargo up to Jan 29, 2026 The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular ... -
Distinct extracellular signatures of active-dendritic chemical and electrical synapses differentially contribute to ripple-frequency oscillations
Extracellular field potentials across brain regions exhibit distinct signatures that depend on several region-specific attributes, including spatiotemporal patterns of afferent inputs, anatomical and physiological properties ... -
Role of the miR319-JAW-TCP module in the growth and development of the female reproductive organ in Arabidopsis thaliana
Named after their founding members TEOSINTE BRANCHED1, CYCLOIDEA, and PROLIFERATING CELL FACTORs, the TCP transcription factors have been investigated for their diverse role in plant growth and development. The five ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Identification and Characterization of Interacting Proteins of TARANI/ Ubiquitin Specific Protease-14 in Arabidopsis thaliana
Regulation of organ shape and size is an important area of research in developmental biology in both plants and animals. The shape of a leaf is determined primarily by endogenous factors such as gene function. Only a ... -
Design, Biophysical Characterization, and Serum Epitope Mapping of SARS-CoV-2 RBD Vaccine Immunogens
Embargo up to Jan 9, 2026 -
Deciphering canonical and non-canonical role of splicing factor Prp16 in pathogenic yeast C. neoformans
RNA splicing is a ubiquitous process during eukaryotic gene expression, where non-coding introns are removed from primary transcripts to form functional mRNA. This vital process is carried out by the spliceosome, a large ... -
Mathematical and Computational Modelling Investigations of the Role of Trait Variation in Savanna-Woodland Bistable systems
Over the last decade, several studies have shown the importance of individual variation in natural populations. Theoretical ecological studies are beginning to incorporate trait variations in models, but they continue to ... -
Understanding the anticancer potential of inhibitor of BCL2, Disarib in Oral Cancer Cells and its Toxicological Evaluation in Rodents
Overexpression of BCL2 has been reported in several cancers, such as B-cell lymphomas, leukemias, colorectal adenocarcinoma, breast cancer, prostate cancer, and oral cancer, making it an excellent target for cancer treatment. ... -
Investigations on the invasiveness of chemo-resistant epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is a debilitating gynecological malignancy wherein patients frequently develop resistance to the first-line chemotherapeutic drugs carboplatin and docetaxel, resulting in poor survival rates. ... -
Elucidating mechanisms regulating GC-C signalling in colorectal cancer
Colorectal cancer is the third most frequently diagnosed cancer and the second major cause of cancer death worldwide. Classical therapies for treating colorectal cancer are mostly nonspecific and, therefore, are associated ... -
Neuroimmune Regulation in Caenorhabditis elegans: The Roles of the Amphid Sensory Neurons and Olfaction in Host Immune Responses
The ability of hosts to rapidly sense invading pathogens and mount an appropriate response is paramount for host survival. Pathogens, pervasive in the natural world, present a perpetual threat to host organisms. Examining ... -
Regulatory events governing host-C. albicans interaction: potential implications for wound healing
Regulatory events governing host-C. albicans interaction: potential implications for wound healing. Candida albicans is an opportunistic fungal pathogen that resides commensally in 50% of the world population and is known ... -
Identifying novel molecular players involved in patterning the dorsal longitudinal muscles of Drosophila melanogaster
Pattern formation, a fundamental concept in developmental biology, describes how living systems organise complex structures from initially undifferentiated cells. This process, influenced by genetic information, underpins ...
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