Division of Biological Sciences
Recent Submissions
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Mathematical and Computational Modelling Investigations of the Role of Trait Variation in Savanna-Woodland Bistable systems
Over the last decade, several studies have shown the importance of individual variation in natural populations. Theoretical ecological studies are beginning to incorporate trait variations in models, but they continue to ... -
Understanding the anticancer potential of inhibitor of BCL2, Disarib in Oral Cancer Cells and its Toxicological Evaluation in Rodents
Overexpression of BCL2 has been reported in several cancers, such as B-cell lymphomas, leukemias, colorectal adenocarcinoma, breast cancer, prostate cancer, and oral cancer, making it an excellent target for cancer treatment. ... -
Investigations on the invasiveness of chemo-resistant epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is a debilitating gynecological malignancy wherein patients frequently develop resistance to the first-line chemotherapeutic drugs carboplatin and docetaxel, resulting in poor survival rates. ... -
Elucidating mechanisms regulating GC-C signalling in colorectal cancer
Colorectal cancer is the third most frequently diagnosed cancer and the second major cause of cancer death worldwide. Classical therapies for treating colorectal cancer are mostly nonspecific and, therefore, are associated ... -
Neuroimmune Regulation in Caenorhabditis elegans: The Roles of the Amphid Sensory Neurons and Olfaction in Host Immune Responses
The ability of hosts to rapidly sense invading pathogens and mount an appropriate response is paramount for host survival. Pathogens, pervasive in the natural world, present a perpetual threat to host organisms. Examining ... -
Regulatory events governing host-C. albicans interaction: potential implications for wound healing
Regulatory events governing host-C. albicans interaction: potential implications for wound healing. Candida albicans is an opportunistic fungal pathogen that resides commensally in 50% of the world population and is known ... -
Identifying novel molecular players involved in patterning the dorsal longitudinal muscles of Drosophila melanogaster
Pattern formation, a fundamental concept in developmental biology, describes how living systems organise complex structures from initially undifferentiated cells. This process, influenced by genetic information, underpins ... -
Deciphering the role of DJ-1 homologs in alleviating carbonyl and oxidative stress in Arabidopsis thaliana
The present study aims to elucidate the physiological role of plant DJ-1 homologs in Arabidopsis thaliana under various abiotic stress conditions. It seeks to provide deeper insights into the diverse functions of plant ... -
Mechanistic Insights into Radioprotection by Caffeine and Understanding Impact of Caffeine on Nonhomologous End Joining: Implications in Cancer
Maintenance of genome integrity is of utmost importance for the survival of any organism. Genetic instability is usually associated with various disorders, and it often leads to premature aging and predisposition to various ... -
Investigating DJ-1 homologs in maintaining genome integrity through glycation repair of macromolecules: Implications in regulating mitochondrial health
The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ... -
Impact of low-dose radiation in inducing mitochondria dependent inflammaging - A new model for cellular senescence
Recent advances in the field of aging have identified cellular senescence as one of the major hallmarks of aging and the accumulation of senescent cells in a biological system is associated with inflammation and many age ... -
Investigation of the stress-induced translatome of matrix-deprived cancer cells
Cancer remains one of the leading causes of death worldwide, in spite of all the ongoing research in the field of oncology. While there have been some breakthroughs in the past 50 years, metastatic tumors remain the bane ... -
Hominini-specific regulation of cell cycle by stop codon readthrough of FEM1B
In certain mRNAs ribosomes continue translation beyond the canonical stop codon to generate longer isoform with a C-terminal extension. This phenomenon is termed stop codon readthrough (SCR). Previously, a genome-wide ... -
Structural characterization of Staphylococcal γ-hemolysin in the presence of a lipid environment using single particle cryo-EM
γ-Hemolysin (γ-HL) is a quintessential bicomponent β-pore forming toxin (β-PFT) belonging to the arsenal of “superbug” Staphylococcus aureus. Here, we performed negative staining-TEM and single particle cryo-EM-based ... -
Integrative multiscale modeling and simulations of biomolecules with experimentally testable predictions
This thesis delves into four separate research works related to Integrative multiscale modeling and simulations of biomolecules. The first work deals with the puzzling case of the Pleckstrin Homology Domain (PHD), which ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Investigating the role of DUSP14 and Rab7A in endo-lysosomal trafficking in mammalian cells Eukaryotic cells maintain homeostasis and interact with their environment through intricate metabolic processes, including the ... -
Role of RTEL1 helicase in the regulation of homologous recombination during DNA replication
Homologous recombination (HR) plays an essential role in the repair of DNA double-strand breaks (DSBs), replication stress responses, and genome maintenance. Although the mechanism of HR has been extensively studied in the ... -
Unravelling Crosstalk in Two-component Signalling Systems and Its Role in Mycobacterium Species
A typical two-component signaling system (TCSs) is composed of two transcriptionally coupled proteins (cognate pair) where one is a signal-sensing histidine kinase (HK) and the other, an output-generating response regulator ... -
Elucidation of the structure-function relationship of the Saccharomyces cerevisiae HORMA domain-containing proteins Hop1 and Rev7
DNA-based transactions like replication, repair, recombination and transcription are central to survival, inheritance and evolution. Not surprisingly, these mechanisms are tightly regulated by a myriad of protein-protein, ... -
Studies on the mechanisms of action and the physiological roles of MutT1 in mycobacteria
Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, thrives and proliferates inside host macrophages, encountering a high level of reactive oxygen species and reactive nitrogen intermediates which is generated by the ...
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