Division of Biological Sciences
Recent Submissions
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An expedition through local and global features of intrinsically disordered proteins using computational lenses
The traditional view in Structural Biology centered on the “one sequence–one structure–one function” paradigm, which emphasized a unique, folded state of protein as the basis for its biological activity. However, this ... -
Mechanistic insights into the recruitment of viral type 2 IRES to ribosomal pre-initiation complex and its interaction with eIF4 factors and PTB1
Viruses often employ internal ribosome entry sites (IRESs) in their genomic RNA to hijack the host’s translational machinery. The IRES elements are characterized by unique secondary and tertiary RNA structures capable of ... -
Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics
Full text embargo up to Dec 11, 2026 Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ... -
Understanding the molecular mechanisms of redox-dependent mitochondrial homeostasis mediated by DJ-1 paralogs in Saccharomyces cerevisiae
Mitochondrial integrity is a crucial determinant of overall cellular health. Mitochondrial dysfunction and impediments in regulating organellar homeostasis contribute majorly to the pathophysiological manifestation of ... -
Design of viral entry inhibitors and vaccines
Full text Embargo upto 12/12/2026 Human Immunodeficiency Virus type 1 (HIV-1) remains one of the most persistent global health threats, despite significant efforts in the development of vaccines and major strides in ... -
Theoretical investigation on the geminal proton-carnon-13 Coupling constants
It has been concluded from the present study that the geminal proton coupling of carboxyl (carbonyl) carbon-13 has an angular dependence of the form: A+Bcos?2?A + B \cos^2 \thetaA+Bcos2? based on the relative orientation ... -
Elucidating the TSC2-mediated transcriptional regulation of miR-514b-3p
The PI3K-AKT-MTOR signalling axis is pivotal in regulating cell survival, proliferation, and growth. Tuberous sclerosis complex (TSC) is a well-established negative regulator of this pathway, which primarily acts by ... -
Influence of population bottlenecks on the evolution of sociality in synthetic life-cycle
Cooperation requires individuals to invest their resources for the benefit of others. Cooperative behaviours often involve the secretion of costly public goods, which can be exploited by spontaneous mutant cheater cells ... -
Tuning the Circuit, Steering the Swarm: CASY-1 in Synaptic and Behavioral Modulation
Disruptions in neuromodulatory signaling are a hallmark of several neurodevelopmental and psychiatric disorders. However, the molecular mechanisms that fine-tune neuromodulation across circuits and behaviors remain poorly ... -
Epigenetic repression of stemness genes by the TCP/KNOX-II transcription factors in simple leaf development of Arabidopsis
Leaves are initiated as primordia at the flanks of the shoot apical meristem. Primordia in the simple-leaved species such as Arabidopsis produce single lamina, whereas those in compound-leaved species such as tomato ... -
Understanding the Mechanism of DNA Double-Strand Break (DSB) Repair in Mitochondria and Various Mammalian Organs.
Various exogenous and endogenous agents can damage DNA. Exogenous agents include chemicals and radiation, such as ionizing radiations and UV rays, while endogenous agents include DNA replication errors, reactive oxygen ... -
Deciphering the role of miR-631 in the pathogenesis of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial cells of the oral cavity. The Asian population has the highest incidence of OSCC and despite advances in its treatment, the five-year ... -
Immunogen design to enhance Influenza and SARS-CoV-2 vaccine efficacy
Influenza and SARS-CoV-2 are pleomorphic viruses that cause respiratory diseases in humans and present significant public health threats. Vaccination has been essential in controlling the spread of these infections and ... -
Exploring and Targeting Dysregulated GPCRs in Glioblastoma: A Comprehensive Investigation
G protein–coupled receptors (GPCRs) represent the largest family of membrane receptors and are key regulators of cellular signaling. While extensively targeted in various diseases, their potential in oncology especially ... -
Heterogeneous host-pathogen interactions contribute to antibiotic tolerance in Mycobacterium tuberculosis
Eradication of Mycobacterium tuberculosis (Mtb) requires strategies targeting bacteria inside the host. Mtb exhibits heterogeneity in redox metabolism inside macrophages to evade killing by anti-TB drugs. If and how ... -
Structural Insights of Inter-domain Interactions in Multi-domain Proteins
Embargo up to August 11, 2026. Proteins are essential biomolecules whose diverse functions stem from their modular architecture built from independently folding units called domains. This thesis investigates the nature and ... -
Structural and Mechanistic Studies of Gaba Transporter Isoform 1
The plasma membrane neurotransmitter transporter, GAT1, is responsible for the clearance of inhibitory neurotransmitter γ-aminobutyric acid (GABA) from the synaptic cleft. Targeting GABA reuptake by inhibiting GAT1, hence ... -
Physiological significance of tRNA sequences and modifications in regulation of the bacterial growth
Transfer RNA or tRNA is one of the vital components of translation machinery where it acts as an adaptor molecule to bring amino acid to the ribosome in response to the genetic code in mRNA. Its key role is to decode the ... -
Deciphering the mechanism behind the division of the Salmonella containing vacuole (SCV) and the immunomodulation strategy employed by Salmonella Typhimurium
The genus Salmonella represents flagellated, Gram-negative, rod-shaped anaerobic bacteria which is a leading cause of food-borne illness and causes enteric disease in a wide range of animals. In humans and several warm-blooded ...
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