Microbiology and Cell Biology (MCB)
Recent Submissions
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Interaction of the TCP4 protein with other transcription factors and its effect on Arabidopsis shoot apex
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) class of proteins are plant-specific transcription factors with a non-canonical basic helix-loop-helix (bHLH) domain involved in both DNA-binding and ... -
Exploring the roles of nucleoid-associated protein HU and two of its interacting proteins in Mycobacterium tuberculosis pathogenesis
Embargo up to Jan 29, 2026 The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular ... -
Role of the miR319-JAW-TCP module in the growth and development of the female reproductive organ in Arabidopsis thaliana
Named after their founding members TEOSINTE BRANCHED1, CYCLOIDEA, and PROLIFERATING CELL FACTORs, the TCP transcription factors have been investigated for their diverse role in plant growth and development. The five ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Identification and Characterization of Interacting Proteins of TARANI/ Ubiquitin Specific Protease-14 in Arabidopsis thaliana
Regulation of organ shape and size is an important area of research in developmental biology in both plants and animals. The shape of a leaf is determined primarily by endogenous factors such as gene function. Only a ... -
Deciphering canonical and non-canonical role of splicing factor Prp16 in pathogenic yeast C. neoformans
RNA splicing is a ubiquitous process during eukaryotic gene expression, where non-coding introns are removed from primary transcripts to form functional mRNA. This vital process is carried out by the spliceosome, a large ... -
Regulatory events governing host-C. albicans interaction: potential implications for wound healing
Regulatory events governing host-C. albicans interaction: potential implications for wound healing. Candida albicans is an opportunistic fungal pathogen that resides commensally in 50% of the world population and is known ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Investigating the role of DUSP14 and Rab7A in endo-lysosomal trafficking in mammalian cells Eukaryotic cells maintain homeostasis and interact with their environment through intricate metabolic processes, including the ... -
Studies on the mechanisms of action and the physiological roles of MutT1 in mycobacteria
Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, thrives and proliferates inside host macrophages, encountering a high level of reactive oxygen species and reactive nitrogen intermediates which is generated by the ... -
Deciphering the role of spermidine in Salmonella Typhimurium pathogenesis
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative, facultative anaerobic bacterium. It infects a broad range of hosts, causing symptoms such as gastroenteritis, abdominal pain, inflammatory diarrhoea ... -
Studies on the translation initiation factors in bacteria and mitochondria
The process of protein synthesis is a fundamental and key event in living organisms. The process of translation initiation is assisted by specific proteins known as initiation factors. In bacteria, three initiation ... -
Understanding the mechanism of host deacetylase SIRT1 and SIRT3 in the modulation of Salmonella pathogenesis
Host sirtuins are one of the important modulators of host immuno-metabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to Salmonellosis is largely unknown. Here, we ... -
Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an organism. Dysregulation in the process of wound healing leads to the production of excess extracellular matrix leading to fibrosis. ... -
miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of CVB3 infection-induced cell death ... -
Functional characterisation of splicing factor Slu7 in Cryptococcus neoformans – roles in cell cycle, constitutive and alternate splicing
Fungal genomes, including in pathogenic yeasts like Cryptococcus neoformans (Cnn) and Candida albicans are rich with short introns. 99% of Cryptococcus neoformans genes have introns with an average of 5 introns per gene ... -
Structure-function and evolution of a unique uracil DNA glycosylase, UdgX, from Mycobacterium smegmatis
Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ... -
Studying the role of small GTPase Rab14 in the regulation of endosomal function
The endomembrane system and their associated membrane trafficking are fundamental features of eukaryotic cell biology. These processes are regulated by small GTP-binding proteins that acts as molecular switches to ... -
Understanding the role of Cysteine desulfurases in Mycobacterium tuberculosis physiology and pathogenesis
The Mycobacterium tuberculosis (Mtb) persistence inside the human host relies on successful adaptation to host-induced stresses such as reactive oxygen species (ROS), reactive nitrogen species (RNS), iron starvation, low ... -
Understanding the mechanisms of polarity establishment and nuclear envelope breakdown in Caenorhabditis elegans embryos
Polarity establishment is critical for the development and stem cell lineages. The one-cell stage of the Caenorhabditis elegans embryo polarizes soon after fertilization. As a result, the first division of the embryo ... -
Rice transcription factors OsMADS2 and OsMADS4 regulate floret organ development: Deciphering their gene targets, traits and functions related to their unequal genetic redundancy
Organs in modern dicot flowers are positioned in concentric rings (whorls). The outermost whorl has green protective sepals, internal to which are showy petals, and the reproductive stamen and carpel whorls. Florets of ...
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