Microbiology and Cell Biology (MCB)
Recent Submissions
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Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Investigating the role of DUSP14 and Rab7A in endo-lysosomal trafficking in mammalian cells Eukaryotic cells maintain homeostasis and interact with their environment through intricate metabolic processes, including the ... -
Studies on the mechanisms of action and the physiological roles of MutT1 in mycobacteria
Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, thrives and proliferates inside host macrophages, encountering a high level of reactive oxygen species and reactive nitrogen intermediates which is generated by the ... -
Deciphering the role of spermidine in Salmonella Typhimurium pathogenesis
Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative, facultative anaerobic bacterium. It infects a broad range of hosts, causing symptoms such as gastroenteritis, abdominal pain, inflammatory diarrhoea ... -
Studies on the translation initiation factors in bacteria and mitochondria
The process of protein synthesis is a fundamental and key event in living organisms. The process of translation initiation is assisted by specific proteins known as initiation factors. In bacteria, three initiation ... -
Understanding the mechanism of host deacetylase SIRT1 and SIRT3 in the modulation of Salmonella pathogenesis
Host sirtuins are one of the important modulators of host immuno-metabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to Salmonellosis is largely unknown. Here, we ... -
Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an organism. Dysregulation in the process of wound healing leads to the production of excess extracellular matrix leading to fibrosis. ... -
miRNA-based regulation of Coxsackievirus B3 replication and pathogenesis
Coxsackievirus B3 (CVB3) is a single-stranded, positive-sense RNA virus known to cause acute myocarditis, pancreatitis, and aseptic meningitis. In many cases, the long-term impact of CVB3 infection-induced cell death ... -
Functional characterisation of splicing factor Slu7 in Cryptococcus neoformans – roles in cell cycle, constitutive and alternate splicing
Fungal genomes, including in pathogenic yeasts like Cryptococcus neoformans (Cnn) and Candida albicans are rich with short introns. 99% of Cryptococcus neoformans genes have introns with an average of 5 introns per gene ... -
Structure-function and evolution of a unique uracil DNA glycosylase, UdgX, from Mycobacterium smegmatis
Mycobacterium smegmatis, a soil bacterium, faces multiple challenges in its environment, including exposure to reactive oxygen species (ROS), reactive nitrogen intermediates (RNI), radiation, and various other chemical ... -
Studying the role of small GTPase Rab14 in the regulation of endosomal function
The endomembrane system and their associated membrane trafficking are fundamental features of eukaryotic cell biology. These processes are regulated by small GTP-binding proteins that acts as molecular switches to ... -
Understanding the role of Cysteine desulfurases in Mycobacterium tuberculosis physiology and pathogenesis
The Mycobacterium tuberculosis (Mtb) persistence inside the human host relies on successful adaptation to host-induced stresses such as reactive oxygen species (ROS), reactive nitrogen species (RNS), iron starvation, low ... -
Understanding the mechanisms of polarity establishment and nuclear envelope breakdown in Caenorhabditis elegans embryos
Polarity establishment is critical for the development and stem cell lineages. The one-cell stage of the Caenorhabditis elegans embryo polarizes soon after fertilization. As a result, the first division of the embryo ... -
Rice transcription factors OsMADS2 and OsMADS4 regulate floret organ development: Deciphering their gene targets, traits and functions related to their unequal genetic redundancy
Organs in modern dicot flowers are positioned in concentric rings (whorls). The outermost whorl has green protective sepals, internal to which are showy petals, and the reproductive stamen and carpel whorls. Florets of ... -
Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars.
Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ... -
Studies on Δ40p53 mediated regulation of specific coding and non-coding RNAs: Consequences on cellular processes
p53 is a crucial transcriptional regulator which influences almost every possible pathway that impinges on the life of a cell. As expected of such an instrumental protein, the molecular network of p53 is as diverse as it ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Elucidating the role of SNARE Syntaxin 1A in regulating lysosome and melanosome function
SNAREs are transmembrane proteins that localize to specific membranes and facilitate the process of membrane/vesicle fusion. SNAREs mediate the fusion by binding with their respective cognate SNAREs. SNAREs mediate the ... -
Investigating the role of an atypical dual-specificity phosphatase DUSP28 in mammalian cells
Dual-specificity phosphatases (DUSPs) belong to the protein tyrosine phosphatases (PTP) subfamily and dephosphorylate, both serine/threonine and tyrosine residues of proteins and non-protein substrates. A subgroup of ... -
Characterization of XRN2-mediated microRNA turnover mechanism and its pathophysiological significance in eukaryotes
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that are extensively involved in the posttranscriptional regulation of gene expression in eukaryotes. Comprehensive studies on miRNA expression and function have ... -
Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells
In animal cells, the duplicated genetic material is aligned on a microtubule-based structure known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, and the sister chromatids get ...
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