Microbiology and Cell Biology (MCB)
Recent Submissions
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Characterizing the viral factors and host determinants that control Dengue virus infection and pathogenesis
Background – Dengue virus is a mosquito-borne flavivirus that is the causative agent for dengue fever, which progresses to dengue shock syndrome in many patients. It is estimated that around 390 million dengue infections ... -
Role of Queuosine in Codon-Anticodon Interaction
The speed and accuracy of the process of protein synthesis is very high. The major step at which the fidelity of translation is governed is at the step of codon?anticodon pairing. An erroneous codon?anticodon pairing can ... -
Purification and characterization of DNA-dependent RNA polymerase II from candida utilis
Abstract not available -
Importance of formylation in eubacterial translation initiation
Initiation of protein synthesis in all organisms occurs with the amino acid methionine. In the case of eubacteria and eukaryotic organelles, methionine is further modified to formylmethionine by the enzyme methionyl?tRNA ... -
Molecular characterisation of Saccharomyces cerevisiae Prp17protein and its interacting partners
In majority of eukaryotic genes, removal of intervening sequences from pre?mRNA is essential for its expression. A ribonucleoprotein complex called the spliceosome catalyses the removal of intron by two sequential ... -
Lectin from mimosa invisa L and its role in rhizobium recognition
Understanding the specificity of the legume-Rhizobium symbiosis may help in improving biological nitrogen fixation in several ways. The causes for this specificity have been studied in only a few systems like clover, ... -
Studies on the mode of inhibition of avian myeloblastosis virus multipulication by cupric isonicotinic acid hydrazide complex
The primary objectives of cancer chemotherapy programs include the screening and evaluation of new chemicals and natural products in experimental systems for their anticancer activity and the recommendation of new anticancer ... -
Role of PARP16 in Cardiac Remodeling
Role of PARP16 in cardiac remodeling Cardiac remodeling, a complex process involving alterations in myocardial structure and function, is a major contributor to heart failure. While physiological remodeling supports cardiac ... -
Influence of population bottlenecks on the evolution of sociality in synthetic life-cycle
Cooperation requires individuals to invest their resources for the benefit of others. Cooperative behaviours often involve the secretion of costly public goods, which can be exploited by spontaneous mutant cheater cells ... -
Epigenetic repression of stemness genes by the TCP/KNOX-II transcription factors in simple leaf development of Arabidopsis
Leaves are initiated as primordia at the flanks of the shoot apical meristem. Primordia in the simple-leaved species such as Arabidopsis produce single lamina, whereas those in compound-leaved species such as tomato ... -
Exploring and Targeting Dysregulated GPCRs in Glioblastoma: A Comprehensive Investigation
G protein–coupled receptors (GPCRs) represent the largest family of membrane receptors and are key regulators of cellular signaling. While extensively targeted in various diseases, their potential in oncology especially ... -
Heterogeneous host-pathogen interactions contribute to antibiotic tolerance in Mycobacterium tuberculosis
Eradication of Mycobacterium tuberculosis (Mtb) requires strategies targeting bacteria inside the host. Mtb exhibits heterogeneity in redox metabolism inside macrophages to evade killing by anti-TB drugs. If and how ... -
Physiological significance of tRNA sequences and modifications in regulation of the bacterial growth
Transfer RNA or tRNA is one of the vital components of translation machinery where it acts as an adaptor molecule to bring amino acid to the ribosome in response to the genetic code in mRNA. Its key role is to decode the ... -
Deciphering the mechanism behind the division of the Salmonella containing vacuole (SCV) and the immunomodulation strategy employed by Salmonella Typhimurium
The genus Salmonella represents flagellated, Gram-negative, rod-shaped anaerobic bacteria which is a leading cause of food-borne illness and causes enteric disease in a wide range of animals. In humans and several warm-blooded ... -
Eco-evolutionary consequences of bacterial predation
Predator-prey interactions pervade all ecosystems at all levels of biological organization. Ample research using higher eukaryotes has demonstrated the role of predator-prey interactions on the evolution of ecological and ... -
Unravelling the spindle-independent function of cortical force-generating machinery (LIN-5/GPR-1/2) during cleavage furrow formation and abscission in C. elegans embryos
Cytokinesis marks the final stage of cell division, where a single mother cell divides into two daughter cells. This intricate process begins with the assembly of an actomyosin-based cleavage furrow at the equatorial ... -
Role of Sirtuin6 in the maintenance of cardiac lysosomal homeostasis
The response to cardiac stress can be divided into two phases- an initial adaptive compensatory phase followed by a maladaptive decompensatory phase. Protein homeostasis in cardiomyocytes has been observed to behave ... -
Insights into ISWI group Chromatin Remodeler BAZ1A (bromodomain adjacent to zinc finger domain 1A): A Key Player of E2F transcription program in glioma
ISWI (Imitation Switch) family of chromatin remodeling complexes mobilize nucleosomes to control DNA accessibility, which manages various DNA template-associated processes like replication, transcription, and repair. ...
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