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The Influence of Glycerol and Specific Genes on the Asymmetric Cell Division in Mycobacteria
The Influence of Glycerol and Specific Genes
on the Asymmetric Cell Division in Mycobacteria
Submitted by Atul Pradhan (S.R. No. 03-04-00-10-11-14-1-11678)
Background Information: Mycobacteria maintain heterogeneity in ...
Mechanistic and Functional Insights into Mycobacterium bovis BCG Triggered PRR Signaling : Implications for Immune Subversion Strategies
Pathogenic mycobacteria are among the most dreadful pathogens known to mankind as one third of the world’s population is latently infected with M. tuberculosis, the causative agent of pulmonary tuberculosis. Host immune ...
Wnt/β-Catenin-dependent Epigenetic Factors Shape Host Immune Responses During Mycobacterial Infection
The genus mycobacterium has more than 120 species of bacteria; one being M. tuberculosis (Mtb), the etiological agent of tuberculosis (TB). During infection, the host mounts a heightened immune response to contain the ...
Response of Mycobacterium tuberculosis to Hypoxia and its physiological Significance - A Morphological and Molecular Level Study
Mycobacterium tuberculosis (Mtb) has evolved as an important clinical pathogen due to its ability to gain multidrug resistance, to enter into latency to persist there and to get reactivated from the latent infection in ...
Understanding the Functions of Nucleoid Associated Proteins in Mycobacterium tuberculosis
The prokaryotic genome, though lacks a membrane bound organelle for its housing, is restricted to only about 25% of the cytoplasmic space called the nucleoid. The dramatic compaction required for the genome to fit in is ...
Mechanism of the Development of Genetic Resistance to Antibiotics Mediated by three Reactive Oxygen Species in Mycobacterium smegmatis
Bacteria use different means to survive in the continued presence of antibiotics. We find that upon prolonged exposure to antibiotics, mycobacteria put up a triphasic response comprised of a logarithmic reduction of the ...
Immune Evasion and Survival Strategies of Mycobacterium : Role for Host Signaling Pathway-Mediated Micro RNAs and Epigenetic Regulation
(2018-05-09)
The genus Mycobacterium represents more than 120 species of bacteria including the pathogenic M. tuberculosis, the etiological agent of tuberculosis. The host mounts a robust inflammatory and cell-mediated response to ...
Functional Insights into PRR-Driven SHH Signaling : Implications for Host-Microbial Interactions
(2018-07-26)
Mycobacterium are important human pathogens and their strength lies in establishing acute infections, latent infections as well as co-existing with other dreadful infectious agents like HIV. The success of mycobacterium ...
Topoisomerases from Mycobacteria : Insights into the Mechanism, Regulation and Global Modulatory Functions
(2018-03-09)
The eubacterial genome is maintained in a negatively supercoiled state which facilitates its compaction and storage in a small cellular space. Genome supercoiling can potentially influence various DNA transaction processes ...
DNA Repair Proteins in Mycobacteria and their Physiological Importance
(2018-03-09)
DNA repair proteins in mycobacteria and their physiological importance
Mycobacterium tuberculosis, the causative organism of tuberculosis, resides in the host macrophages where it is subjected to a plethora of stresses ...