Now showing items 1-20 of 261
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Lectin from mimosa invisa L and its role in rhizobium recognition
Understanding the specificity of the legume-Rhizobium symbiosis may help in improving biological nitrogen fixation in several ways. The causes for this specificity have been studied in only a few systems like clover, ... -
Studies on the mode of inhibition of avian myeloblastosis virus multipulication by cupric isonicotinic acid hydrazide complex
The primary objectives of cancer chemotherapy programs include the screening and evaluation of new chemicals and natural products in experimental systems for their anticancer activity and the recommendation of new anticancer ... -
Role of PARP16 in Cardiac Remodeling
Role of PARP16 in cardiac remodeling Cardiac remodeling, a complex process involving alterations in myocardial structure and function, is a major contributor to heart failure. While physiological remodeling supports cardiac ... -
Influence of population bottlenecks on the evolution of sociality in synthetic life-cycle
Cooperation requires individuals to invest their resources for the benefit of others. Cooperative behaviours often involve the secretion of costly public goods, which can be exploited by spontaneous mutant cheater cells ... -
Epigenetic repression of stemness genes by the TCP/KNOX-II transcription factors in simple leaf development of Arabidopsis
Leaves are initiated as primordia at the flanks of the shoot apical meristem. Primordia in the simple-leaved species such as Arabidopsis produce single lamina, whereas those in compound-leaved species such as tomato ... -
Exploring and Targeting Dysregulated GPCRs in Glioblastoma: A Comprehensive Investigation
G protein–coupled receptors (GPCRs) represent the largest family of membrane receptors and are key regulators of cellular signaling. While extensively targeted in various diseases, their potential in oncology especially ... -
Heterogeneous host-pathogen interactions contribute to antibiotic tolerance in Mycobacterium tuberculosis
Eradication of Mycobacterium tuberculosis (Mtb) requires strategies targeting bacteria inside the host. Mtb exhibits heterogeneity in redox metabolism inside macrophages to evade killing by anti-TB drugs. If and how ... -
Physiological significance of tRNA sequences and modifications in regulation of the bacterial growth
Transfer RNA or tRNA is one of the vital components of translation machinery where it acts as an adaptor molecule to bring amino acid to the ribosome in response to the genetic code in mRNA. Its key role is to decode the ... -
Deciphering the mechanism behind the division of the Salmonella containing vacuole (SCV) and the immunomodulation strategy employed by Salmonella Typhimurium
The genus Salmonella represents flagellated, Gram-negative, rod-shaped anaerobic bacteria which is a leading cause of food-borne illness and causes enteric disease in a wide range of animals. In humans and several warm-blooded ... -
Eco-evolutionary consequences of bacterial predation
Predator-prey interactions pervade all ecosystems at all levels of biological organization. Ample research using higher eukaryotes has demonstrated the role of predator-prey interactions on the evolution of ecological and ... -
Unravelling the spindle-independent function of cortical force-generating machinery (LIN-5/GPR-1/2) during cleavage furrow formation and abscission in C. elegans embryos
Cytokinesis marks the final stage of cell division, where a single mother cell divides into two daughter cells. This intricate process begins with the assembly of an actomyosin-based cleavage furrow at the equatorial ... -
Role of Sirtuin6 in the maintenance of cardiac lysosomal homeostasis
The response to cardiac stress can be divided into two phases- an initial adaptive compensatory phase followed by a maladaptive decompensatory phase. Protein homeostasis in cardiomyocytes has been observed to behave ... -
Insights into ISWI group Chromatin Remodeler BAZ1A (bromodomain adjacent to zinc finger domain 1A): A Key Player of E2F transcription program in glioma
ISWI (Imitation Switch) family of chromatin remodeling complexes mobilize nucleosomes to control DNA accessibility, which manages various DNA template-associated processes like replication, transcription, and repair. ... -
Interaction of the TCP4 protein with other transcription factors and its effect on Arabidopsis shoot apex
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) class of proteins are plant-specific transcription factors with a non-canonical basic helix-loop-helix (bHLH) domain involved in both DNA-binding and ... -
Exploring the roles of nucleoid-associated protein HU and two of its interacting proteins in Mycobacterium tuberculosis pathogenesis
Embargo up to Jan 29, 2026 The genome in prokaryotes is restricted to a membrane-less compartment termed nucleoid. The genome is maintained in the compacted state within the nucleoid with the help of three key cellular ... -
Role of the miR319-JAW-TCP module in the growth and development of the female reproductive organ in Arabidopsis thaliana
Named after their founding members TEOSINTE BRANCHED1, CYCLOIDEA, and PROLIFERATING CELL FACTORs, the TCP transcription factors have been investigated for their diverse role in plant growth and development. The five ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Identification and Characterization of Interacting Proteins of TARANI/ Ubiquitin Specific Protease-14 in Arabidopsis thaliana
Regulation of organ shape and size is an important area of research in developmental biology in both plants and animals. The shape of a leaf is determined primarily by endogenous factors such as gene function. Only a ... -
Deciphering canonical and non-canonical role of splicing factor Prp16 in pathogenic yeast C. neoformans
RNA splicing is a ubiquitous process during eukaryotic gene expression, where non-coding introns are removed from primary transcripts to form functional mRNA. This vital process is carried out by the spliceosome, a large ...