Biochemistry (BC)
Recent Submissions
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Physiological Significance of Stop Codon Readthrough
Regulation of translation, the process by which ribosomes synthesize proteins from mRNAs, is critical to maintain cellular proteostasis. Dysregulation of translation is implicated in several neurodegenerative, metabolic, ... -
Studies on the metabolism of aminophenols
Certain o-aminophenols like 3-hydroxykynurenine and 3-hydroxyanthranilic acid are known to be precursors of nicotinic acid as well as of certain phenoxazinone antibiotics and insect pigments. The metabolism of 3-hydroxyanthranilic ... -
Studies on the action of nbromsuccinimide on Hemoglobin and lysozyne
The above detailed account of the role of various groups in enzyme function amply illustrates the approaches to the study of the structural basis of enzyme action. One particular fact emerges out of the present account. ... -
Studies on the amino-acid composition and nutritive value of some Indian food stuffs
The thesis entitled “Studies on the Amino Acid Composition and Nutritive Value of Some Indian Foodstuffs” presents the following pieces of research work carried out by the candidate: Standardisation of the microbiological ... -
Metabolism of naphthalene and methylnaphthalenes in Pseudomonas putida : Elucidation of catabolic pathways and purification and properties of 1,2-Dihydroxynaphthalene dioxygenase
I. Polycyclic aromatic hydrocarbons (PAHs), which include naphthalene and alkyl-substituted naphthalenes, are universal products of combustion of organic matter. The mutagenic and carcinogenic nature of several PAHs makes ... -
Studies on the antibiotic principles of garcinia morella and allium sativum
Part I Section A: The preparation, purification and properties of morellin, the active principle of Garcinia morella, have been described. By chromatographic technique on silica gel columns three distinct pigments viz., ... -
Some aspects of the metabolism of mandelic acid by Aspergillus Niger
The two first enzymes in the pathway for the metabolism of mandelic acid by Aspergillus niger, namely D(-)-mandelate oxidase and L(+)-mandelate oxidase, which respectively catalyze the oxidation of the two enantiomers of ... -
Molecular dissection of Komagataella phaffii Rtg1–RtgX function and development of a glutamate-responsive protein expression platform
In Saccharomyces cerevisiae, the basic helix-loop-helix leucine zipper (bHLH-LZ) proteins Rtg1 and Rtg3 form a heterodimeric transcription factor complex that mediates the retrograde response. In Candida albicans, these ... -
Regulation of the Expression of Ribosomal Proteins by Small Downstream ORFs
Eukaryotic mRNAs have historically been believed to harbour a single open reading frame (ORF). However, over the last decade, ribosome profiling has revealed extensive ribosome occupancy in the untranslated regions ... -
Understanding the molecular mechanisms of redox-dependent mitochondrial homeostasis mediated by DJ-1 paralogs in Saccharomyces cerevisiae
Mitochondrial integrity is a crucial determinant of overall cellular health. Mitochondrial dysfunction and impediments in regulating organellar homeostasis contribute majorly to the pathophysiological manifestation of ... -
Understanding the Mechanism of DNA Double-Strand Break (DSB) Repair in Mitochondria and Various Mammalian Organs.
Various exogenous and endogenous agents can damage DNA. Exogenous agents include chemicals and radiation, such as ionizing radiations and UV rays, while endogenous agents include DNA replication errors, reactive oxygen ... -
Modeling the CD8+ T cell response to solid tumors: A multi-scale immunoinformatics approach to prognosticating disease outcome
Robust CD8 T cell activity is crucial for anti-tumor immune response. CD8 T cells keep tumors in check using direct effector mechanisms that cause tumor death. The key to this activity is the recognition of tumor cells as ... -
Deciphering Hypoxic Adaptations in Cutibacterium acnes using Multi-omics Profiling and Systems Modelling
The opportunistic skin anaerobe Cutibacterium acnes (C. acnes) contributes to skin homeostasis with its antioxidant and immunomodulatory activities. C. acnes (formerly known as Propionibacterium acnes) is an aerotolerant, ... -
Elucidating the diverse functions of RGG-motif containing proteins
One year embargo upto 20/2/2026 RGG-motif containing proteins represent one of the major subsets of RNA-binding proteins characterized by the presence of RGG/RG repeats. These proteins have been associated with a wide ... -
Understanding the anticancer potential of inhibitor of BCL2, Disarib in Oral Cancer Cells and its Toxicological Evaluation in Rodents
Overexpression of BCL2 has been reported in several cancers, such as B-cell lymphomas, leukemias, colorectal adenocarcinoma, breast cancer, prostate cancer, and oral cancer, making it an excellent target for cancer treatment. ...

