Division of Biological Sciences: Recent submissions
Now showing items 1-20 of 1740
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Studies on the carbohydrate metabolism of mycobacterium tuberculosis H37Rv.
Abstract Not Available -
Studies angiospermic root parasite santalum album and its experimental host dolichos lablab
While most of the plants are autotrophic and are the main sustenance of life on this planet, a few plants have acquired the parasitic habit and thrive on other plants. The extent of this dependence varies, and so also the ... -
Studies on the metabolism of ethionamide, a second line antitubercular drug
Ethionamide (2-ethyl, 4-thioisonicotinamido) is an active tuberculostatic second-line drug, which plays an important role in the treatment of pulmonary tuberculosis resistant to one or more of the classical drugs. The drug ... -
Studies on experimental cancer immunosuppressive activity and mechanisms of action of mithramycin
As a first step in evaluating the chemotherapeutic efficacy of mithramycin, an antitumor antibiotic, and correlating its toxic, antitumor, and immunosuppressive properties, the following studies were carried out: The ... -
Some myxobacteria and their activities
Among the fruiting forms, Myxococcus species were more common in soils. They were also comparatively easy to isolate and cultivate. i 20 : Therefore, it was decided to carry out further work on these species. As mentioned ... -
Studies on areca catechulinn with special ref to ganooerma lucidum : a fungal pathogen of area palm
The fungus Ganoderma lucidum is one of the common pathogens of a number of tropical palms such as coconut, arecanut etc. Although the pathogenicity of the fungus on a wide range of hosts has been recorded, there are ... -
Dynamics of DNA Double-strand Break Repair Pathways and Unlocking New Therapeutic Opportunities by Exploiting DSB Repair in Head and Neck Cancer
Among different types of DNA damage, DNA double-strand breaks (DSBs) are the most lethal, disrupting genome integrity and potentially causing cancer via faulty repair. Major DSB repair pathways in humans include homology-directed ... -
Genetic and molecular characterization of Drosophila melanogaster mutants with compromised motor and reproductive functions
Insects are among the most successful organisms, a success attributed to the evolution of flight and high reproductive capacity. Both locomotion and reproduction are regulated at multiple levels of tissue organization, ... -
Mechanistic Insights into the Role of IGFBP-2 in Glioblastoma
Insulin-like Growth Factor Binding Proteins (IGFBPs 1-6) regulate the half-life and bioavailability of Insulin-like Growth Factors (IGFs). They play important roles in embryonic development, postnatal growth, and disease ... -
Studies on the Evolution of Aromatic Beta-Glucoside Catabolic Systems under Different Stress Conditions in Escherichia coli
The genetic systems involved in the utilization of aromatic -glucosides in Escherichia coli consist of the bgl, asc, and chb operons, along with the bglA locus encoding phospho- -glucosidase A. The bgl and asc operons are ... -
Structural and biochemical characterization of proteins involved in peptidoglycan synthesis in gram-positive bacteria
The peptidoglycan layer is a major component of the cell wall in gram-positive bacteria. It consists of glycan chains and peptide stems containing both L- and D-amino acids. This layer influences cell shape, motility, ... -
Biochemical and Conformational Characterization of S.aureus Penicillin Binding Proteins
Abstract Not Available -
Androgen-regulated gene expression in the rat ventral prostate : Differential effects of orchidectomy and flutamide treatment
Thus, the present study provides a comprehensive view and complexities associated with in vivo studies on androgen-regulated gene expression in the rat ventral prostate using the castration model. Also, this study is the ... -
Insights into transcriptional regulation of the receptor guanylyl cyclase C gene : role of HNF4, coup-TFs and GATA-6 transcription factors
Transcriptional regulation in eukaryotes is a multi-step process involving the ordered assembly of multiprotein complexes on regulatory regions of DNA. DNA-bound specific transcription factors trigger the recruitment of ... -
Identification of novel interacting proteins for hamartin and tuberin and a minimal region of hamartin necessary for its interaction with tuberin
In order to find interacting partners for the 133 a.a. long evolutionarily conserved region of hamartin and the C‑CCD of tuberin, these regions were cloned in‑frame in the yeast two‑hybrid DNA‑BD vector pGBT9. The hamartin ... -
Structural basis for the carbohydrate specificities of moraceae lectins
Lectins are multivalent carbohydrate-binding proteins of non-immune origin. They have received considerable attention due to their ability to recognize diverse sugar structures with high specificity. Lectins are involved ... -
Cyclic AMP, nucleotide cyclases and phosphodiesterases insights from computational, biochemical and functional studies in mycobacteria
Cyclic nucleotides (3 ,5 -cyclic AMP and cGMP) were among the first second messengers to be identified, and their roles in diverse signalling pathways have since been widely studied. Nucleotide cyclases (which synthesize ... -
Structural and biochemical studies on salmonella typhimurium aldose 1-epimerase
Mutarotase plays a key role in carbohydrate metabolism by catalyzing the reversible conversion of - and -anomers of aldose sugars. In this thesis, I report the X-ray crystallographic analysis of Salmonella typhimurium ...