Molecular Reproduction, Development and Genetics (MRDG)
Recent Submissions
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Impact of low-dose radiation in inducing mitochondria dependent inflammaging - A new model for cellular senescence
Recent advances in the field of aging have identified cellular senescence as one of the major hallmarks of aging and the accumulation of senescent cells in a biological system is associated with inflammation and many age ... -
Investigation of the stress-induced translatome of matrix-deprived cancer cells
Cancer remains one of the leading causes of death worldwide, in spite of all the ongoing research in the field of oncology. While there have been some breakthroughs in the past 50 years, metastatic tumors remain the bane ... -
Unravelling Crosstalk in Two-component Signalling Systems and Its Role in Mycobacterium Species
A typical two-component signaling system (TCSs) is composed of two transcriptionally coupled proteins (cognate pair) where one is a signal-sensing histidine kinase (HK) and the other, an output-generating response regulator ... -
Investigating the maintenance of X- chromosome inactivation in extra-embryonic endoderm and epiblast stem cells
In eutherian female mammals, one of the X-chromosomes gets inactivated to compensate for the expression dosage of X-linked genes between the sexes. X-chromosome inactivation (XCI) serves as a paradigm of epigenetic memory ... -
The role of neuronal integrity in maintaining gut functions and homeostasis
This thesis investigates two main aspects of neuronal integrity and gut health. Firstly, it examines the intricate relationship between neuronal integrity and the maintenance of gut homeostasis in Drosophila melanogaster. ... -
Structural insight into unique features of the Translational apparatus in Plants
Plants are constantly challenged with a variety of biotic and abiotic stress conditions. Being sessile, plants cannot evade these conditions. Most of these sudden changes in environmental conditions require a quick change ... -
Role of PdtaS-PdtaR two component signalling system in metabolic adaptation in Mycobacterium spp.
The ability to perceive and adapt to environmental fluctuations, both internal and external, is a fundamental characteristic of life across diverse organisms. Within the context of pathogenic bacteria such as Mycobacterium ... -
Role of 3D-organization of the X-inactivation centre in imprinted X-chromosome inactivation
The connection between 3D-genome organization and genome regulation is one of the fundamental questions in modern biology. In a nucleus, the genome is organized through different layers of 3D-organization such as ... -
Peritoneal colonization of ovarian cancer
The primary cause of mortality associated with cancer is metastasis, i.e., the spread of transformed cells from the site of oncogenesis to secondary loci within the body. Epithelial ovarian cancer (EOC) is a debilitating ... -
Establishment of a knock-in mouse model expressing a hypomorphic variant of receptor guanylyl cyclase C
Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ... -
Evaluation of Cytogenotoxic Potential and Embryotoxicity of KRS Cauvery River Water in Zebrafish (Danio Rerio)
Pollutants and other forms of environmental stress (lifestyle and social behaviour) are of global concern due to significant adverse effects on human health. The term "exposome" has emerged as a concept in environmental ... -
Genetic and environmental determinants of swarming in Pseudomonas aeruginosa
Swarming, in bacteria, is a type of group translocation phenomenon observed in several flagellated species characterized by their ability to spread across solid or semi-solid surfaces rapidly – often with a distinct colony ... -
Investigating the role of miR-198 in oral squamous cell carcinoma pathogenesis
Evidence supports the critical role of microRNA (miRNA) dysregulation in several diseases including cancers. The aberrant expression of numerous tumor suppressor and oncogenic miRNAs is a well-established driving factor ... -
Development of patient-derived tumor models toward understanding disease biology and drug screening
Cancer is a complex disease of uncontrolled cell proliferation, which cripples the normal functioning of tissues. According to GLOBOCAN 2020, an estimated 19.3 million new cancer cases and around 10 million cancer deaths ... -
Understanding cholesterol homeostasis and its impact on GPCR signalling in aging
Full text embargo One year up to July 2024 Aging is defined as the time-related deterioration of physiological functions necessary for survival of organisms. Despite significant progress in the extension of human lifespan ... -
Investigating the role of AMPK in mammary gland alveologenesis and lactation
AMP-activated kinase (AMPK) is an energy sensor that regulates cell growth and metabolism. Reports from our laboratory and others have shown the context-specific role of AMPK signaling in breast cancer. However, its role ... -
Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach
Urolithin-A mitigates synaptic dysfunctions associated with epilepsy through VDAC1 inhibition: A novel therapeutic approach Epilepsies are a group of neurological disorders with a prevalence of 70 million people worldwide ... -
Development of 3D model and understanding translational regulation of breast cancer
Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ... -
Biochemical and structural studies to provide insights into initiator tRNA delivery by eIF2A in noncanonical translation initiation
Eukaryotic initiation factor 2A (eIF2A), a non-canonical translation initiation factor, delivers initiator tRNA (tRNAi) onto the 40S ribosomal subunit in a codon-dependent and GTP-independent manner, unlike the canonical ... -
A study of extracellular matrix dynamics in epithelial cancer progression with a special focus on ovarian cancer spheroidogenesis
Epithelial ovarian cancer (EOC) is one of the most debilitating gynecological cancers in women worldwide due to its insidious symptoms. The predominant subtype of ovarian cancer: high-grade serous ovarian carcinoma (HGSOC), ...
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