Department of Developmental Biology & Genetics (DBG, earlier called MRDG)
Recent Submissions
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Early commitment of cell types and a morphogenetic role for calcium in dictyostelium discoideum
Abstract Not Available -
Environmental and Genetic Drivers of Swarming and Surface Competitiveness in Pseudomonas aeruginosa
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen. It is known for its multidrug resistance and ability to cause severe infections, including pneumonia, urinary tract infections, and diabetic foot ulcers. ... -
Gene that interacts with the cell cycle in saccharomyces cerevisiae and influences development in Dictyostelium discoideum
Cell cycle phase and cellular calcium play key roles in determining cell fate during differentiation and development in Dictyostelium discoideum. Earlier studies have shown that these two cellular functions are correlated ... -
Human chorionic gonadotropin : Recombinant DNA expression and structure-function relationship studies
Human Chorionic Gonadotropin (hCG) is a member of the family of glycoprotein hormones, which also includes the pituitary-derived Thyroid Stimulating Hormone (TSH), Follicle Stimulating Hormone (FSH), and Luteinizing Hormone ... -
Stuides on sperm maturation, fertilization and embryo development in rodents
One of the most fascinating aspects of biology is the conception, growth, and birth of the young. Central to these processes are gamete maturation, fertilization, and early embryonic development. An understanding of these ... -
Dependence of post-aggregative cell fate on early phenotypicdifferences with respect to cellular calcium and cell cycle phase in Dictyostelium discoideum
The social amoeba Dictyostelium discoideum is an excellent model system to study cell differentiation and embryonic development. Its life cycle consists of a unicellular phase involving feeding, growth, and multiplication, ... -
Studies on recombinant DNA expression of follicle stimulating hormone and its receptor
Follicle Stimulating Hormone (FSH), a pituitary gonadotropin, belongs to the family of glycoprotein hormones and plays a crucial role in mammalian reproduction. It is a heterodimer consisting of an -subunit noncovalently ... -
Role of AMPK in regulating morphogenetic processes during cancer and embryonic development
Title: Role of AMPK in regulating morphogenetic processes during cancer and development Abstract: AMP-activated protein kinase (AMPK) is a central regulator of cellular energy homeostasis, integrating metabolic status ... -
Guanylyl cyclase C receptor : Regulation by protein kinase C
Guanylyl cyclases are enzymes that catalyze the conversion of magnesium-bound GTP to cGMP. Cyclic GMP then acts as a second messenger to a variety of exogenous and endogenous ligands. Guanylyl cyclases are of two types: ... -
Regulation of guanylyl cyclase C signalling : glycosylation, localisation and identification of downstream effectors
Guanylyl cyclase C (GC-C) belongs to the receptor guanylyl cyclases that synthesize cGMP, a ubiquitous second messenger. GC-C is a glycoprotein receptor with an extracellular ligand-binding domain, a single transmembrane ... -
Biomechanical and biochemical regulation by the extracellular matrix of breast cancer migration
Although under active investigation, alterations within the microenvironment that are causative to, and a consequence of, tumor progression are only beginning to be better appreciated through advances in imaging, experimental, ... -
Mechanistic insights into the recruitment of viral type 2 IRES to ribosomal pre-initiation complex and its interaction with eIF4 factors and PTB1
Viruses often employ internal ribosome entry sites (IRESs) in their genomic RNA to hijack the host’s translational machinery. The IRES elements are characterized by unique secondary and tertiary RNA structures capable of ... -
Elucidating the TSC2-mediated transcriptional regulation of miR-514b-3p
The PI3K-AKT-MTOR signalling axis is pivotal in regulating cell survival, proliferation, and growth. Tuberous sclerosis complex (TSC) is a well-established negative regulator of this pathway, which primarily acts by ... -
Deciphering the role of miR-631 in the pathogenesis of oral squamous cell carcinoma
Oral squamous cell carcinoma (OSCC) is a malignant neoplasm originating from the epithelial cells of the oral cavity. The Asian population has the highest incidence of OSCC and despite advances in its treatment, the five-year ... -
Towards a molecular understanding of gastrointestinal disorders due to mutations in receptor Guanylyl Cyclase C
Towards a molecular understanding of gastrointestinal disorders due to mutations in receptor Guanylyl Cyclase C Receptor guanylyl cyclase C (GC-C) is a complex multidomain protein receptor characterised by its guanylyl ... -
Deciphering the function of sesaminol as an anti-obesity and anti-MAFLD molecule
Obesity and its associated metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated liver disease (MAFLD), pose significant global health challenges. ... -
Cyclic nucleotide-binding proteins in mycobacteria
Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ... -
Investigations on the invasiveness of chemo-resistant epithelial ovarian cancer
Epithelial ovarian cancer (EOC) is a debilitating gynecological malignancy wherein patients frequently develop resistance to the first-line chemotherapeutic drugs carboplatin and docetaxel, resulting in poor survival rates. ... -
Elucidating mechanisms regulating GC-C signalling in colorectal cancer
Colorectal cancer is the third most frequently diagnosed cancer and the second major cause of cancer death worldwide. Classical therapies for treating colorectal cancer are mostly nonspecific and, therefore, are associated ...
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