Myofibrillogenesis is a complex process involving assembly of many structural proteins in an orchestrated spatio-temporal manner to form a highly ordered contractile sarcomeric unit. Mutations in the proteins involved in ...

The Corpus luteum (CL) is a dynamic endocrine structure that develops in the ovary from the remnants of the ovulated follicle and plays a critical role in the control of estrous/menstrual cycle as well as in establishment ...

Immune response to pathogens is energetically expensive to the host. In this study, we show that Caenorhabditis elegans exposed for 8 hours to pathogenic Gram-positive bacteria, Enterococcus faecalis and Staphylococcus ...

Metabolic flexibility is one of the key factors that underpin mycobacterial physiology and pathogenesis. During infection, mycobacteria shift towards utilising host-derived fatty acids, lipids, cholesterol and cholesterol-esters. ...

Aging is defined in an evolutionary biological context as a steady state decline in the specific fitness components of an organism due to internal physiological deterioration. The most profound and important contribution ...

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates a plethora of functions including cell growth, development, and differentiation. TGF-β plays a major role in the inhibition of normal cell ...

Developmental pathways such as Notch are known to regulate self-renewal and cell fate decisions in embryonic and adult tissue-specific stem cells, while deregulation of Notch signalling is associated with malignant ...

Many genetic regulatory networks are required to define the overall characters in a living organism. Characters which are necessary for survival in the wild are often canalized, such that despite genetic and environmental ...

The mammalian heart is the first organ formed during development. It forms the crux of the circulatory system of the body and pumps blood (and therefore, nutrients) to all parts of the body. The continuous functioning of ...

Muscle development and function are highly synchronized processes that involve simultaneous action of several transcription factors, signalling cascades, kinases and phosphatases, ion channels, structural proteins and ...