Molecular Biophysics Unit (MBU)
Recent Submissions
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Mechanistic Insights into the Role of IGFBP-2 in Glioblastoma
Insulin-like Growth Factor Binding Proteins (IGFBPs 1-6) regulate the half-life and bioavailability of Insulin-like Growth Factors (IGFs). They play important roles in embryonic development, postnatal growth, and disease ... -
Studies on the Evolution of Aromatic Beta-Glucoside Catabolic Systems under Different Stress Conditions in Escherichia coli
The genetic systems involved in the utilization of aromatic -glucosides in Escherichia coli consist of the bgl, asc, and chb operons, along with the bglA locus encoding phospho- -glucosidase A. The bgl and asc operons are ... -
Genetic and molecular characterization of Drosophila melanogaster mutants with compromised motor and reproductive functions
Insects are among the most successful organisms, a success attributed to the evolution of flight and high reproductive capacity. Both locomotion and reproduction are regulated at multiple levels of tissue organization, ... -
Structural and biochemical characterization of proteins involved in peptidoglycan synthesis in gram-positive bacteria
The peptidoglycan layer is a major component of the cell wall in gram-positive bacteria. It consists of glycan chains and peptide stems containing both L- and D-amino acids. This layer influences cell shape, motility, ... -
Biochemical and Conformational Characterization of S.aureus Penicillin Binding Proteins
Abstract Not Available -
Androgen-regulated gene expression in the rat ventral prostate : Differential effects of orchidectomy and flutamide treatment
Thus, the present study provides a comprehensive view and complexities associated with in vivo studies on androgen-regulated gene expression in the rat ventral prostate using the castration model. Also, this study is the ... -
Insights into transcriptional regulation of the receptor guanylyl cyclase C gene : role of HNF4, coup-TFs and GATA-6 transcription factors
Transcriptional regulation in eukaryotes is a multi-step process involving the ordered assembly of multiprotein complexes on regulatory regions of DNA. DNA-bound specific transcription factors trigger the recruitment of ... -
Identification of novel interacting proteins for hamartin and tuberin and a minimal region of hamartin necessary for its interaction with tuberin
In order to find interacting partners for the 133 a.a. long evolutionarily conserved region of hamartin and the C‑CCD of tuberin, these regions were cloned in‑frame in the yeast two‑hybrid DNA‑BD vector pGBT9. The hamartin ... -
Structural basis for the carbohydrate specificities of moraceae lectins
Lectins are multivalent carbohydrate-binding proteins of non-immune origin. They have received considerable attention due to their ability to recognize diverse sugar structures with high specificity. Lectins are involved ... -
Cyclic AMP, nucleotide cyclases and phosphodiesterases insights from computational, biochemical and functional studies in mycobacteria
Cyclic nucleotides (3 ,5 -cyclic AMP and cGMP) were among the first second messengers to be identified, and their roles in diverse signalling pathways have since been widely studied. Nucleotide cyclases (which synthesize ... -
Structural and biochemical studies on salmonella typhimurium aldose 1-epimerase
Mutarotase plays a key role in carbohydrate metabolism by catalyzing the reversible conversion of - and -anomers of aldose sugars. In this thesis, I report the X-ray crystallographic analysis of Salmonella typhimurium ... -
Monoclonal Antibodies as Probes to Protein Structure and Function : Insights into human Chorionic gonadotropin
Thanks to Köhler and Milstein, monoclonal antibodies (mAbs) can serve as excellent probes for protein structure and function. However, the method used to study the interaction between an antigen and its cognate mAb has a ... -
Kinetic studies on enoyl- ACP reductase from plasmodium falciparum : A potential target of antimalarials
Enoyl-ACP reductase (FabI) catalyzes the rate-determining step in the type II fatty acid synthesis (FAS) pathway. This pathway is present in plants and bacteria. However, the recent demonstration of this pathway in the ... -
cGMP-binding, cGMP-specific phosphodiesterase, PDE5 : expression and regulation
Regulation of PDE5 in cGMP Signaling Pathways Abstract and Synopsis Introduction Cellular signaling involves the transmission of both intracellular and extracellular signals. Binding of a ligand to its receptor ... -
Single chain glycoprotein hormones : structure-function studies
Structure-Function Studies of Glycoprotein Hormones Using Fusion Protein Strategy Abstract and Synopsis Introduction Structure-function studies of proteins aim to elucidate how individual amino acid residues are oriented ... -
Structure and function of aspartic proteinases
Crystallographic and Computational Studies on Aspartic Proteinases: Structural and Functional Insights Abstract and Synopsis Chapter 1 - Introduction Aspartic proteinases are a superfamily of enzymes involved in diverse ... -
Genes involved in cell type specification and morphogenesis in Dictyostelium discoideum
Calcium-Dependent Regulation of Gene Expression and Morphogenesis in Dictyostelium discoideum Abstract and Synopsis Introduction Differentiation and morphogenesis occur in concert to ensure the development of multicellular ... -
Genetic analysis of activation and silencing of the cryptic bgl operon of Escherichia coli
Activation and Silencing of the bgl Operon in Escherichia coli: Genetic and Physiological Perspectives Abstract and Synopsis Introduction The bgl operon of E. coli is one of four genetic systems in Enterobacteriaceae for ... -
Transforming growth factor-B5 promoter regulation : role of MyoD and Nkx2.5 transcription factors
Abstract Not Available
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