Molecular Biophysics Unit (MBU)
Recent Submissions
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Synthesis and structural studies of self-complementary oligodeoxyribonucleotides
The thesis entitled “Synthesis and Structural Studies of Self Complementary Oligodeoxyribonucleotides” is aimed at understanding the role of sequence specific backbone conformation of DNA oligomers in protein–DNA interactions ... -
Spectroscopic investigation of an antifertility agent gossypol and an ionophore antibiotic, Lasalocid A
The present thesis has as its objective the study of the structure and interaction of two biologically active, polyfunctional organic molecules. Spectroscopic studies on gossypol and lasalocid A form the subject matter of ... -
Studies on conformational Transitions : Helix coil Transition Parameters for L-Alanine & L-Leucine in Mixed organic solvent system.
The helix, proposed by Linus Pauling in the early 1950s, is known to be an important secondary structure in globular and fibrous proteins. It is of great interest to understand the propensities of individual amino acid ... -
Synthetic and spectroscopic studeis on fragments of the membrane channel forming
Abstract not available -
Conformation of proline ring from C nuclear magnetic spin lattice relaxation times
Apart from the natural fascination that the dynamics of molecules generate, the important role that molecular dynamics play in the functioning of biological molecules is well recognized. On the other hand, information about ... -
Further crystallographic studies on lysozyme
This thesis is concerned with further structural studies-primarily using crystallographic techniques-on the well known enzyme lysozyme. The introductory chapter briefly surveys the available X ray results, which are ... -
Synthesis and conformational analysis of cyclic cysine peptides
Disulfide bridges are important determinants of protein and peptide structures. The formation of covalent crosslinks between cysteine residues that are far apart in the primary structure can result in the formation of loops ... -
Membrane channel forming polypeptides studies on alamethicin, antiamoebin and related peptides
Membrane channel forming polypeptides possessing ionophoric activity have been widely investigated as models for transmembrane ion transport and for their effects on both artificial and natural membranes. This thesis ... -
Characterization of proline - containing Alpha-Helices & modelling studies on bacteriorhodopsin
Membrane proteins have a wide range of vital functions and serve as enzymes, transporters, receptors, pores, etc. To understand the diverse functions of membrane proteins and fully explain their modes of action, it is ... -
Structural studies on thymidylate synthase and triosephosphate isomerase
In recent years, technological advances have led to dramatic increases in the rate at which structural information can be obtained. Simultaneously, there has been an increase in the size of the macromolecules that can be ... -
Structural and thermodynamic studies on protein stability
Proteins are the products of gene sequences. Their form and function depend on their amino acid sequence. The three dimensional structure of a protein, together with its local concentration and spatial location, determines ... -
Comparative analysis of functions of proteins encoded in the genomes of human and chimpanzee
Abstract not available -
Effect of the stress hormone corticosterone on synaptic transmission and astrocytic release
Glucocorticoids have been shown to influence neuronal function and metabolism in multiple ways. They regulate a wide array of actions-from maintaining cellular homeostasis to mediating stress responses-via myriad downstream ... -
Modular design of synthetic protein mimics, construction of helices
Proteins are essential components of all living cells, and they play multifaceted roles in the vastly complex cellular assemblies within an organism. They control several vital biological processes and display a remarkable ... -
Specificityty of L-arabinose-binding protein: Computer modelling study
The natural affinity and stereoselectivity of carbohydrate binding proteins and enzymes toward their substrates have long been of great interest. Recently, it has been found that such properties are strongly manifested by ... -
A-T base sequences: a theoretical and an experimental study
As a result of the study undertaken, besides predicting the relative stabilities of polynucleotide duplexes containing A–T base pairs, the following conclusions can be drawn (Rajagopalan et al., 1984): a) Base–base ... -
Analysis Of Saccharide Binding To Artocarpus integrifolia (Jackfruit) Agglutinin
Despite the discovery of the first agglutinin in 1888, lectins remained in obscurity until the late 1940s, when it was shown that certain lectins were specific for human blood group antigens. The fact that sugars determine ... -
Structured conformation of biologically important molecules
The thesis titled “Structure and Conformation of Biologically Important Molecules” consists of five chapters. The author has investigated the crystal and molecular structures of two cyclic dipeptides featuring the 2,5 ... -
Conformation of calcium antagonists and their interaction with model membranes
Calcium antagonists are a class of drugs with diverse chemical identities and a wide range of pharmacological activities. At least four different chemical classes can be identified within this group of drugs. This heterogeneity ... -
Legume lectin carbohydrate regognition : clonning of peanut( arachits hypogea) and winged bean (psophocarpus tetragono;obus) agglutinins and reswsign of carbohydrate specificity of PNA
Recognition of cell-surface carbohydrates by lectins has wide implications in important biological processes such as protein targeting to cellular compartments, homing of lymphocytes, host-pathogen interactions, and ...
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