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    Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis 

    Birje, Abhijit
    Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...

    Translation in the 3'Untranslated Region of Mammalian Transcripts 

    Kar, Debaleena
    Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the untranslated region of the mRNA. However, there are certain instances ...

    In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia 

    Tushir, Sheetal
    Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ...

    A Ligase IV/XRCC4-dependent single strand break repair pathway for the maintenance of A/T-rich regions during DNA replication in mammals 

    kumari, Nitu
    The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ...

    The Nse1p RING domain is required for maintaining transcriptional silencing and genomic organization in Saccharomyces cerevisiae 

    Maharshi, Neelam
    Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ...

    Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species 

    Taritla, Sidhartha
    Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...

    Understanding mRNA fate regulation by RGG motif protein, Sbp1 

    Bhatter, Nupur
    Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ...

    Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis. 

    Singh, Satpal
    Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ...

    Role of Mycobacterium tuberculosis UvrD1 and UvrD2 helicases in resolving G-quadruplex DNA structures 

    Saha, Tias
    Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...

    Molecular and biochemical studies on components of transcription regulation, tropane alkaloid biosynthesis and signal transduction in the medicinal plant Datura metel L. 

    Rajvanshi, Pradumn K
    Tropane alkaloids (TA) are among the oldest medicines known to humankind as they possess hallucinogenic and poisonous properties. Datura metel, an herbaceous plant, belongs to the family Solanaceae whose members are well ...
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    AuthorAgarwal, Ankit (1)Akhtar, Md Noor (1)Ambika, D (1)Bakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)... View MoreSubject
    NATURAL SCIENCES (71)
    Cancer (6)Mitochondria (6)DNA repair (4)Helicobacter pylori (3)Salmonella Typhimurium (3)arginine methylation (2)Chromatin (2)DNA (2)DNA double-strand breaks (2)... View MoreHas File(s)Yes (70)No (1)

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