Search
Now showing items 31-40 of 71
Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis
Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...
Translation in the 3'Untranslated Region of Mammalian Transcripts
Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA
sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the
untranslated region of the mRNA. However, there are certain instances ...
In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia
Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ...
A Ligase IV/XRCC4-dependent single strand break repair pathway for the maintenance of A/T-rich regions during DNA replication in mammals
The DNA in our cells is under constant threat from various exogenous and
endogenous sources. To ensure error free and faithful transmission of hereditary material,
human cells employ several DNA repair pathways. Mammalian ...
The Nse1p RING domain is required for maintaining transcriptional silencing and genomic organization in Saccharomyces cerevisiae
Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ...
Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species
Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...
Understanding mRNA fate regulation by RGG motif protein, Sbp1
Cellular events that rely on translation regulation has been well established, however the
molecular details of factors involved in bringing translation control remains inadequately
explored. RNA binding proteins form ...
Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis.
Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ...
Role of Mycobacterium tuberculosis UvrD1 and UvrD2 helicases in resolving G-quadruplex DNA structures
Unresolved G-quadruplex (G4) DNA secondary structures impede DNA replication and can lead to DNA breaks and to genome instability. Helicases are known to unwind G4 structures and thereby facilitate genome duplication. ...
Molecular and biochemical studies on components of transcription regulation, tropane alkaloid biosynthesis and signal transduction in the medicinal plant Datura metel L.
Tropane alkaloids (TA) are among the oldest medicines known to humankind as they possess hallucinogenic and poisonous properties. Datura metel, an herbaceous plant, belongs to the family Solanaceae whose members are well ...