The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ...

Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ...

Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...

Plasmodium sp. is an obligate intracellular protozoan parasite causing malaria and is responsible for more than 500,000 human deaths annually. P. falciparum and P. vivax are the two major species causing malaria in humans. ...

Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ...

Protein synthesis terminates at the first stop codon encountered by the ribosome. In stop codon readthrough, translation termination is suppressed, enabling the ribosomes to continue translation beyond the canonical stop ...

RNA granules are conserved membraneless mRNP complexes that play an important role in determining mRNA fate by affecting translation repression and mRNA decay. Processing bodies (P-bodies) harbor enzymes responsible for ...

Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ...

Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ...

Recombination-activating genes (RAGs) and Activation-induced cytidine deaminase (AID) are lymphoid cell-specific proteins that play crucial roles in the development of adaptive immunity. Diversification of the immune system ...