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Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression
Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ...
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ...
Elucidating the diverse functions of RGG-motif containing proteins
One year embargo upto 20/2/2026
RGG-motif containing proteins represent one of the major subsets of RNA-binding proteins characterized by the presence of RGG/RG repeats. These proteins have been associated with a wide ...
Investigating DJ-1 homologs in maintaining genome integrity through glycation repair of macromolecules: Implications in regulating mitochondrial health
The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ...
Translation in Erythroid cells
Erythrocytes are specialized cells that perform the crucial function of gas exchange in all
vertebrates. Regulation of gene expression was believed to be absent in these cells due
to the absence of nucleus. It was also ...
Hominini-specific regulation of cell cycle by stop codon readthrough of FEM1B
In certain mRNAs ribosomes continue translation beyond the canonical stop codon to generate longer isoform with a C-terminal extension. This phenomenon is termed stop codon readthrough (SCR). Previously, a genome-wide ...
Elucidation of the structure-function relationship of the Saccharomyces cerevisiae HORMA domain-containing proteins Hop1 and Rev7
DNA-based transactions like replication, repair, recombination and transcription are central to survival, inheritance and evolution. Not surprisingly, these mechanisms are tightly regulated by a myriad of protein-protein, ...
Mechanistic Insights into Radioprotection by Caffeine and Understanding Impact of Caffeine on Nonhomologous End Joining: Implications in Cancer
Maintenance of genome integrity is of utmost importance for the survival of any organism. Genetic instability is usually associated with various disorders, and it often leads to premature aging and predisposition to various ...
Deciphering the role of DJ-1 homologs in alleviating carbonyl and oxidative stress in Arabidopsis thaliana
The present study aims to elucidate the physiological role of plant DJ-1 homologs in Arabidopsis thaliana under various abiotic stress conditions. It seeks to provide deeper insights into the diverse functions of plant ...
Role of RTEL1 helicase in the regulation of homologous recombination during DNA replication
Homologous recombination (HR) plays an essential role in the repair of DNA double-strand breaks (DSBs), replication stress responses, and genome maintenance. Although the mechanism of HR has been extensively studied in the ...