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    Role of mammalian RAD51 paralogs in replication stress response and genome maintenance 

    Saxena, Sneha
    The focus of my research has been to understand the molecular mechanisms underlying the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The investigation carried out during this study has ...

    Regulation of carbon metabolism in Pichia pastoris by Mxr1p and identification of novel regulators 

    Gupta, Aditi
    Pichia pastoris (a.k.a. Komagataella phaffii), a widely used yeast for recombinant protein production, is cultured under a variety of conditions ranging from shake flasks to large bioreactors employing minimal, chemically ...

    Studies on the post-transcriptional regulation of genes of glutamate utilization pathway in Pichia pastoris and a role for Retrograde regulation protein 1 

    Dey, Trishna
    The methylotrophic yeast, Pichia pastoris can utilize compounds such as glucose, glycerol, methanol, acetate, amino acids, or oleic acid as the sole source of carbon. However, the regulation of synthesis of key enzymes of ...

    Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas 

    Javadekar, Saniya M
    Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ...

    Host responses in Fas-deficient autoimmune-prone lpr mice upon Salmonella Typhimurium infection 

    Rananaware, Supriya
    Autoimmune diseases can potentially pre-dispose an individual to infections. On the other hand, infections can trigger, exacerbate or ameliorate autoimmunity. Autoimmune Lymphoproliferative Syndrome (ALPS) is a rare genetic ...

    Comparative evaluation of retrograde regulatory proteins (Rtg1p, Rtg2p, and Rtg3p) of Saccharomyces cerevisiae and Pichia pastoris and identification of P. pastoris RtgXp as a novel regulator of multiple metabolic pathways 

    Khatun, Jesminara
    Our work demonstrates for the first time that PpRtgXp, a basic, helix-loop-helix (bHLH) protein, is a global regulator of carbon metabolism. PpRtgXp constitutively localizes inside the nucleus. Despite lacking the C-terminal ...

    Immunomodulatory effects of 7-hydroxy frullanolide, a plant-based sesquiterpene lactone, in inhibiting immune cell responses and roles of disease and vaccination outcomes on Covid-19 mortality 

    Pathak, Sanmoy
    Immunomodulation is a process by which the immune response of the host is either enhanced or suppressed due to various factors which either protects or makes the host more susceptible to particular diseases. Immunomodulators ...

    New insights into the role of condensin in Saccharomyces cerevisiae 

    Lakshmi, Mahendrawada R
    Structural Maintenance of Chromosomes (SMC) complexes are highly conserved from prokaryotes to eukaryotes. Saccharomyces cerevisiae has six SMC proteins which form three SMC-complexes in association with non-SMC subunits ...

    Regulation of RecA nucleoprotein filament stability by RecX and the effects of RecA-membrane interaction on the activities of RecA in mycobacteria 

    Prasad, Deepika
    E. coli RecA is a multifunctional protein known to be associated with the cell membrane, forming foci often located at the cell poles, which gets redistributed along the length of the cell during SOS response. Several lines ...

    Functional characterization of Salmonella Typhimurium encoded Cold Shock Protein E during stress responses, biofilm formation and virulence 

    Ray, Semanti
    Overall, this study reports novel functional roles of S. Typhimurium encoded CspE during bile resistance, biofilm formation and in vivo virulence. It also establishes importance of an uncharacterised protein YciF, implicating ...
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    AuthorAgarwal, Ankit (1)Akhtar, Md Noor (1)Ambika, D (1)Bakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)... View MoreSubject
    NATURAL SCIENCES (71)
    Cancer (6)Mitochondria (6)DNA repair (4)Helicobacter pylori (3)Salmonella Typhimurium (3)arginine methylation (2)Chromatin (2)DNA (2)DNA double-strand breaks (2)... View MoreHas File(s)Yes (70)No (1)

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