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    Exploring the Marine Algicolous Endophytic Fungi: A Promising Source of Novel Cancer Therapeutics 

    Sahoo, Subhadarsini
    Cancer is the second leading cause of mortality globally, with over 6 million new cases diagnosed annually. Research on effective therapies is crucial due to the disease's complexity. Natural materials in chemotherapy have ...

    Metabolic and Pharmacological Modulations During IFN-γ signaling 

    Chattopadhyay, Avik
    Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ...

    Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression 

    Waingankar, Tejashree Pradip
    The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ...

    Understanding the adaptive responses of Salmonella Typhimurium during bile stress 

    Singh, Madhulika
    Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ...

    Deciphering the biochemical and biophysical properties of the Holliday junction resolvases RuvC and RuvX from Mycobacterium smegmatis 

    Agarwal, Ankit
    Homologous recombination (HR) is a ubiquitous cellular process that occurs in all three domains of life as well as in DNA and RNA viruses. In eukaryotes, HR is critically important for homology-directed DNA repair (HDDR) ...

    Algorithms for Investigating, Decoding and Designing ligand recognition sites in proteins - A Structural Bioinformatics Approach to Studying Protein Function 

    Sankar, Santhosh
    All physical processes in living organisms are driven by specific biomolecular interactions. Elucidating the characteristics of biomolecular interactions between proteins and their respective small molecule ligands can ...

    Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis 

    Birje, Abhijit
    Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...

    Translation in the 3'Untranslated Region of Mammalian Transcripts 

    Kar, Debaleena
    Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the untranslated region of the mRNA. However, there are certain instances ...

    In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia 

    Tushir, Sheetal
    Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ...

    A Ligase IV/XRCC4-dependent single strand break repair pathway for the maintenance of A/T-rich regions during DNA replication in mammals 

    kumari, Nitu
    The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ...
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    AuthorAgarwal, Ankit (1)Akhtar, Md Noor (1)Ambika, D (1)Bakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)... View MoreSubject
    NATURAL SCIENCES (71)
    Cancer (6)Mitochondria (6)DNA repair (4)Helicobacter pylori (3)Salmonella Typhimurium (3)arginine methylation (2)Chromatin (2)DNA (2)DNA double-strand breaks (2)... View MoreHas File(s)Yes (70)No (1)

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