Browsing Division of Biological Sciences by Title
Now showing items 974-993 of 1426
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Solution NMR studies of a potent subtilisin inhibitor from Budgett’s frog and the catalytic subunit of AHAS
This thesis involves a detailed structural study of two molecular systems, a small disulfide-rich peptide LL-TIL and a large catalytic subunit of AHAS. Subtilisin inhibitors play an important role in fighting against ... -
Solution NMR Studies Of E.Coli Acetohydroxy Acid Synthase (AHAS) I
(2010-04-13)Branched chain amino acids are classified as essential amino acids since their biosynthetic routes or pathways are restricted only to micro-organisms, fungi and plants. Given their unique distribution, the enzymes of the ... -
Solution NMR Studies Of Peptide Toxins From Cone Snails And Scorpion
(2010-09-13)Major constituents of the venom of various animals are peptidogenic in nature. Marine snails belonging to the species Conus are venomous predators that use small, structurally constrained peptides present in their venom ... -
Solution Structural Studies And Substrate Binding Properties Of The Amino-Terminal Domain Of E.coli Pantothenate Synthetase
(2011-03-29)Pantothenate synthetase (PS), which catalyzes the last step in the pantothenate (vitamin B5) biosynthesis, is a dimeric enzyme present in bacteria, fungi and plants. The enzymatic properties of PS from Escherichia Coli, ... -
Solution Structure Studies on the Effects of Aromatic Interactions and Cross-Strand Disulfide Bonds on Protein Folding
(2018-07-05)The work presented in this thesis focusses primarily on the determination of protein structure at atomic resolution, with NMR spectroscopy as the principle investigative tool. The thesis is divided into four parts. Part I ... -
Solution structures and conformational isomerism of novel conopeptides from Indian marine cone snails
This thesis describes the structure determination of peptides found in marine cone snails’ venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction to the cone snails, conopeptides, ... -
Solution Structures and Dynamics of Conotoxins and Small MutS Related Domain from Helicobacter Pylori MutS2
(2018-06-08)The work presented in this thesis describes the determination of structures of peptides and proteins at atomic resolution. Nuclear Magnetic Resonance (NMR) spectroscopy was used as the principal method of investigation. ... -
Solution structures and interaction studies of mycobacterial MazEF6 toxin-antitoxin system
Toxin-Antitoxin (TA) systems are stress response systems found on plasmids and chromosomes of bacteria and archaea. They are involved in important functions such as plasmid maintenance, programmed cell death, persister ... -
Some aspects of the metabolism of mandelic acid by Aspergillus Niger
The two first enzymes in the pathway for the metabolism of mandelic acid by Aspergillus niger, namely D(-)-mandelate oxidase and L(+)-mandelate oxidase, which respectively catalyze the oxidation of the two enantiomers of ... -
Some aspects of the metabolism of mandelic acid by pseudomonas convexa, Ph.D. Thesis
The metabolism of mandelic acid (phenylglycolic acid) has been studied in detail in several bacteria, and it has been shown that the side chain of mandelic acid is first degraded, resulting in the formation of benzoic acid, ... -
Spatial and Coevolutionary Dynamics of Cooperation
Cooperation is ubiquitous across taxa in the animal kingdom. For example, microbes cooperate in producing antibiotic-resistant biofilms, mammals and birds collectively mob predators, and humans cooperate in utilization of ... -
Spatial and temporal patterns of vegetation- climate interactions
In this thesis, I tried to understand the patterns and processes of vegetation trends at different spatial scales and resolution. The spatial variability in vegetation trends was related to inter and intra-annual changes ... -
Spatial Variation In Interactions Of The Semi-Myrmecophyte Humboldtia Brunonis (Fabaceae) With Ants And Other Invertebrates
(2010-06-01)Despite a long history of investigations on protective ant-plant interactions, since the late 19century (Thomas Belt 1874), a comprehensive quantitative understanding of the adaptations that facilitate these associations ... -
Spatio-Temporal Control Of Drosophila Indirect Flight Muscle Development And Maintenance By The Transcription Factor Erect Wing
(2016-04-27)Muscle development involves concerted action of a repertoire of mechanisms governing myoblast proliferation, migration, fusion and differentiation. Subsequently, there are cellular events administrating proper muscle ... -
Spatio-temporal Regulation of GPCR mediated MAPK Transactivation in Living Cells
Signal transduction is a mode of cellular communication essential for an organism’s sustenance and survival. Cell communication in higher organisms is largely executed by two classes of cell surface receptors i.e. G-protein ... -
Species Ranges, Richness and Replacement of Trees in the Evergreen Forests of the Western Ghats
(2018-05-14)It has been more than two centuries since the latitudinal pattern of increase in taxonomic richness from poles to equator was first documented. After two centuries of research, and with more than two dozen hypotheses ... -
Specificity and mechanism of action of ribonuclease Ti-A computer modelling study
Enzymes recognize their substrates with very high specificity and bring about a large increase in the rates of reactions. A knowledge of the specificity and mechanism of action of enzyme-catalyzed reactions at the molecular ... -
Spectroscopic studies on two biological amphiphiles: melittin and Birlirubin.
This thesis describes spectroscopic studies on two interesting biological amphiphiles, melittin and bilirubin. The former is a 26?residue polypeptide which comprises ~50% of the dry venom of honeybees. Melittin is cytotoxic ...