Solution structures and conformational isomerism of novel conopeptides from Indian marine cone snails

Abstract

This thesis describes the structure determination of peptides found in marine cone snails’ venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction to the cone snails, conopeptides, and basic NMR to determine the tertiary structure. Chapter 2 describes the biological activity of three single disulfide conopeptides from different cone snails. Chapter 3 and 4 describes tertiary structure of novel single disulfide peptide Czon1107 from Conus zonatus and its analogues and Cca1669 from Conus caracteristicus respectively. Chapter 5 investigates the influence of the “pro” on the mature toxin of three disulfide conotoxin. The structural studies described here have been carried out using high-resolution NMR spectroscopic methods