| dc.contributor.advisor | Sarma, Siddhartha P | |
| dc.contributor.author | Madhan Kumar, M | |
| dc.date.accessioned | 2021-05-28T06:01:25Z | |
| dc.date.available | 2021-05-28T06:01:25Z | |
| dc.date.submitted | 2020 | |
| dc.identifier.uri | https://etd.iisc.ac.in/handle/2005/5143 | |
| dc.description.abstract | This thesis describes the structure determination of peptides found in marine cone snails’
venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction
to the cone snails, conopeptides, and basic NMR to determine the tertiary structure.
Chapter 2 describes the biological activity of three single disulfide conopeptides
from different cone snails. Chapter 3 and 4 describes tertiary structure of novel single
disulfide peptide Czon1107 from Conus zonatus and its analogues and Cca1669 from
Conus caracteristicus respectively. Chapter 5 investigates the influence of the “pro” on
the mature toxin of three disulfide conotoxin. The structural studies described here have
been carried out using high-resolution NMR spectroscopic methods | en_US |
| dc.language.iso | en_US | en_US |
| dc.rights | I grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part
of this thesis or dissertation | en_US |
| dc.subject | Snails | en_US |
| dc.subject | Cone snails | en_US |
| dc.subject | structure determination | en_US |
| dc.subject | peptides | en_US |
| dc.subject | NMR | en_US |
| dc.subject | conopeptides | en_US |
| dc.title | Solution structures and conformational isomerism of novel conopeptides from Indian marine cone snails | en_US |
| dc.type | Thesis | en_US |
| dc.degree.name | PhD | en_US |
| dc.degree.level | Doctoral | en_US |
| dc.degree.grantor | Indian Institute of Science | en_US |
| dc.degree.discipline | Faculty of Science | en_US |
