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dc.contributor.advisorSarma, Siddhartha P
dc.contributor.authorMadhan Kumar, M
dc.date.accessioned2021-05-28T06:01:25Z
dc.date.available2021-05-28T06:01:25Z
dc.date.submitted2020
dc.identifier.urihttps://etd.iisc.ac.in/handle/2005/5143
dc.description.abstractThis thesis describes the structure determination of peptides found in marine cone snails’ venom at atomic resolution and their biological activity. Chapter 1 gives a brief introduction to the cone snails, conopeptides, and basic NMR to determine the tertiary structure. Chapter 2 describes the biological activity of three single disulfide conopeptides from different cone snails. Chapter 3 and 4 describes tertiary structure of novel single disulfide peptide Czon1107 from Conus zonatus and its analogues and Cca1669 from Conus caracteristicus respectively. Chapter 5 investigates the influence of the “pro” on the mature toxin of three disulfide conotoxin. The structural studies described here have been carried out using high-resolution NMR spectroscopic methodsen_US
dc.language.isoen_USen_US
dc.rightsI grant Indian Institute of Science the right to archive and to make available my thesis or dissertation in whole or in part in all forms of media, now hereafter known. I retain all proprietary rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertationen_US
dc.subjectSnailsen_US
dc.subjectCone snailsen_US
dc.subjectstructure determinationen_US
dc.subjectpeptidesen_US
dc.subjectNMRen_US
dc.subjectconopeptidesen_US
dc.titleSolution structures and conformational isomerism of novel conopeptides from Indian marine cone snailsen_US
dc.typeThesisen_US
dc.degree.namePhDen_US
dc.degree.levelDoctoralen_US
dc.degree.grantorIndian Institute of Scienceen_US
dc.degree.disciplineFaculty of Scienceen_US


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