Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
Now showing items 88-107 of 126
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Receptor Guanylyl Cyclase C Cross-talk With Tyrosine Kinases And The Adaptor Protein, Crk
(2009-03-06)Signal transduction is a crucial event that enables cells to sense and respond to cues from their immediate environment. Guanylyl cyclase C (GC-C) is a member of the family of receptor guanylyl cyclases. GC-C is a single ... -
Regulation of Chitin Oligosaccharides Utilization in Escherichia Coli
(2018-04-11)The genome of Escherichia coli harbors several catabolic operons involved in the utilization of a wide variety of natural compounds as carbon sources. The chitobiose (chu) operons of E.coli Is involved in the utilization ... -
Regulation of Notch signalling by hypoxia and AMPK in breast cancer
Developmental pathways such as Notch are known to regulate self-renewal and cell fate decisions in embryonic and adult tissue-specific stem cells, while deregulation of Notch signalling is associated with malignant ... -
Regulation of S100A2 by TGF-B : Role in Epithelial -mesenchymal Transition and Tumor Growth
Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates a plethora of functions including cell growth, development, and differentiation. TGF-β plays a major role in the inhibition of normal cell ... -
Role of Activin A Signaling in Breast Cancer
(2017-11-22)Activin-A is a member of transforming growth factor-β (TGF-β) superfamily of cytokines which includes TGF-βs, Activins, Nodal, bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and anti-Mullerian ... -
Role of AMP-Activated Protein Kinase in Cancer Cell Survival under Matrix-Deprived Conditions
(2018-07-19)Cancer progression is a multi-step process requiring cells to acquire specific properties that aid the neoplastic growth. One such property is the ability to survive in the absence of matrix-attachment, a critical necessity ... -
Role of Areca Nut Mediated Epithelial-Mesenchymal Interaction and Involvement of JNK/ATF2/Jun/TGF-beta axis in Oral Submucous Fibrosis Etiopathology
(2018-01-04)Oral submucous fibrosis (OSF) is a debilitating irreversible fibrotic condition of the oral cavity. It is characterized by inflammation and ultimately results in trismus. Patients face difficulty in speaking, swallowing ... -
Role of CG9650 in Neuronal Development And Function of Drosophila Melanogaster
(2017-10-05)The nervous system is the most complex system in an organism. Functioning of the nervous system requires proper formation of neural cells, as well as accurate connectivity and signaling among them. While the major events ... -
Role of Chemokine Receptor, CXCR4 Mediated Signaling in Cellular Senescence
(2017-10-05)Cellular senescence has been proposed to be equivalent to organismal aging and is one of the outcomes of the cell fate decision process in response to DNA damage that occurs in cells. When a cell encounters DNA damage, the ... -
Role Of Insulin-Like Growth Factors Binding Protien 2 (IGFBP2) In Breast Cancer
(2016-04-27)Insulin-like growth factor binding proteins (IGFBPs) modulate the bioavailability of IGFs in circulation. IGFBPs 1-6 bind IGFs with high affinity and can either potentiate or inhibit IGF signaling in a context dependent ... -
Role of Lysyl oxidase in TGF-beta-induced Fibroblast Activation and Cancer-Associated Fibroblast-mediated Breast Cancer Progression
Cancer-associated Fibroblasts (CAFs) are a dominant cell type of the breast cancer microenvironment and are proposed to be involved in metastatic progression. TGF-β has been reported to influence fibroblast to myofibroblast ... -
Roles of Drosophila Beadex and CG9650 in the development and functioning of the larval neuromuscular junctions
In eukaryotes, all voluntary and involuntary actions like, cognition, learning & memory, voluntary movements, feeding, etc., are coordinated by the employment of neuronal circuitry that transmits the signal from the ... -
Rv0805, a novel regulator of central carbon metabolism and cell envelope properties in mycobacteria
Metabolic flexibility is one of the key factors that underpin mycobacterial physiology and pathogenesis. During infection, mycobacteria shift towards utilising host-derived fatty acids, lipids, cholesterol and cholesterol-esters. ... -
Spatio-Temporal Control Of Drosophila Indirect Flight Muscle Development And Maintenance By The Transcription Factor Erect Wing
(2016-04-27)Muscle development involves concerted action of a repertoire of mechanisms governing myoblast proliferation, migration, fusion and differentiation. Subsequently, there are cellular events administrating proper muscle ... -
Spatio-temporal Regulation of GPCR mediated MAPK Transactivation in Living Cells
Signal transduction is a mode of cellular communication essential for an organism’s sustenance and survival. Cell communication in higher organisms is largely executed by two classes of cell surface receptors i.e. G-protein ... -
Spermatogenomics : Correlating Testicular Gene Expression to Human Male Infertility
(2018-06-13)Spermatogenesis is a complex and coordinated process of formation of sperms from the precursor spermatogonia, occurring inside the unique environment existing in the seminiferous epithelium. This process of development, ... -
Stress Signaling In Development And Carcinogenesis : Role Of AMP-Activated Protein Kinase
(2013-08-05)Rapidly growing tumor cells outgrow their blood supply resulting in a microenvironment with reduced oxygen and nutrients. Using an in vitro transformation model we found that cancer cells expressing the SV40 ST antigen ...