The genome of Escherichia coli harbors several catabolic operons involved in the utilization of a wide variety of natural compounds as carbon sources. The chitobiose (chu) operons of E.coli Is involved in the utilization ...

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates a plethora of functions including cell growth, development, and differentiation. TGF-β plays a major role in the inhibition of normal cell ...

The connection between 3D-genome organization and genome regulation is one of the fundamental questions in modern biology. In a nucleus, the genome is organized through different layers of 3D-organization such as ...

Cancer progression is a multi-step process requiring cells to acquire specific properties that aid the neoplastic growth. One such property is the ability to survive in the absence of matrix-attachment, a critical necessity ...

The nervous system is the most complex system in an organism. Functioning of the nervous system requires proper formation of neural cells, as well as accurate connectivity and signaling among them. While the major events ...

Cancer-associated Fibroblasts (CAFs) are a dominant cell type of the breast cancer microenvironment and are proposed to be involved in metastatic progression. TGF-β has been reported to influence fibroblast to myofibroblast ...

The ability to perceive and adapt to environmental fluctuations, both internal and external, is a fundamental characteristic of life across diverse organisms. Within the context of pathogenic bacteria such as Mycobacterium ...

Metabolic flexibility is one of the key factors that underpin mycobacterial physiology and pathogenesis. During infection, mycobacteria shift towards utilising host-derived fatty acids, lipids, cholesterol and cholesterol-esters. ...