Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
Now showing items 25-44 of 126
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Effects of Steroid Hormones on Insulin Sensitivity and Lipogenesis: An Insight into the Involvement of the Wnt Signaling Pathway
The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. In this context, the effect of estradiol (E2), progesterone ... -
Elucidating the Role of Cyclic GMP in Diarrhoea and Intestinal Inflammation
Cyclic guanosine 3’,5’-monophosphate (cGMP) performs a wide range of functions in various cell types and tissues. The cellular levels of cGMP are maintained by the enzymatic conversion of guanosine 5’-triphosphate (GTP) ... -
Elucidation of 17β-Estradiol (E2) Role in the Regulation of Corpus Luteum Function in Mammals : Analysis of IGFBP5 Expression during Ea-mediated Actions
(2017-12-12)Corpus luteum is a transient endocrine structure formed from the ruptured ovarian follicle. Its main function is to secrete P4, a pro-gestational hormone, essential for establishment and maintenance of pregnancy in mammals. ... -
Embryonic Expression of Cytokines: Functional Role of Il-1β During Blastocyst Hatching
The detailed investigation on the embryo-endometrial cytokine expression, in both mouse and hamster, was carried out during the peri-hatching development and it is described in chapter 2. We hypothesize that, for a ... -
Epigenetic Regulators Of Development In The Social Amoeba Dictyostellium Discoideum : The Roles Played By Histone Deacetylases And Heat Shock Protein 90
(2011-01-20)The major evolutionary transition from single-celled to multicellular life is believed to have occurred independently of the main metazoan lineages in the cellular slime moulds, of which Dictyostelium discoideum is the ... -
Epithelial-to-mesenchymal transition and cellular cooperation in cancer progression: Novel roles for AMPK
Epithelial-mesenchymal transition (EMT) is a developmental program hijacked by cancer cells to facilitate metastasis —a multi-step process involving the spread of cancer cells from the primary tumor site and culminating ... -
Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling
(2015-08-19)Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies ... -
Evolution Of New Metabolic Functions By Mutations In Pre-Existing Genes : The chb Operon Of Escherichia Coli As A Paradigm
(2009-07-02)Escherichia coli has the ability to respond to stress such as starvation in a very efficient manner. Under conditions of starvation wherein a novel substrate is provided as a sole nutritional source, Spontaneous mutants ... -
Exploring the Evolution of Cellobiose Utilization in Shigella Sonnei And the Conservation of ChbG Orthologs in Eukaryotes
(2017-10-11)The chb operon constitutes the genes essential for utilization of chitooligosaccharides in Escherichia coli and related species. The six genes of the operon code for a transcriptional regulator (ChbR) of the operon, a ... -
Expression Profiling Of Genes Regulated By TGF-β : Role Of Multiple Signaling Pathways
(2009-05-12)Transforming growth factor-β (TGF-β) is the proto-type member of a super family of secreted proteins comprised of several structurally related, but functionally divergent proteins like the BMP, activin, inhibin, mullerian ... -
Functional Analysis Of Primary Microcephaly Gene Product ASPM
(2013-06-20)Autosomal recessive primary microcephaly (MCPH) is defined by congenital microcephaly and associated mental retardation with head circumference of the affected individual at least 3 standard deviations below age- and ... -
Functional Characterization of CG9650 in development of the Indirect Flight Muscles of Drosophila melanogaster
Muscle development is a complex and multifactorial process involving assembly of thousands of proteins in a precise and synchronized manner over the course of development of an organism. Multiple genes and signalling ... -
Functional characterization of WD40-repeat protein, WDR8, in Zebrafish to gain insight into its role in Isolated Microspherophakia
WD40-repeat (WDR) proteins are a family of proteins that are characterized by widespread occurrence, low level of sequence conservation, common structural conformation (β propeller structure) and functional diversity. ... -
Gene Expression Profiling And Insights Into The Involvement Of The Insulin Signaling Pathway In Oral Cancer
(2008-08-27)1. Despite extensive research on oral squamous cell carcinoma (OSCC), its five-year survival rate has not improved for the last two decades. Effective treatment of OSCC requires the identification of molecular targets to ... -
Genetic Analysis of Wilson Disease in a South Indian Population and Molecular Characterization of 13 Novel ATP7B Mutations
(2018-03-15)Wilson disease (WD) is an autosomal recessive disorder characterized by deposition of copper in the body, mainly in the liver and brain. WD patients present with hepatic, neurological, and psychiatric problems. The diagnosis ... -
Genetic control of Embryonic and Adult muscle development in Drosophila melanogaster by Mlp60A
Many genetic regulatory networks are required to define the overall characters in a living organism. Characters which are necessary for survival in the wild are often canalized, such that despite genetic and environmental ... -
Genetics of Drosophila Indirect Flight Muscles : Unraveling the Roles of Genes Involved in Muscle Development and Function
Myofibrillogenesis is a complex process involving assembly of many structural proteins in an orchestrated spatio-temporal manner to form a highly ordered contractile sarcomeric unit. Mutations in the proteins involved in ... -
Glucose and Lipid Metabolism during Pregnancy and Lactation in Rats : Role of Undercarboxylated Osteocalcin
(2018-02-07)Energy homeostasis is an important physiological mechanism essential for balancingenergy flow through the living systems by managing overall metabolism in the body. Thus, energy homeostasis is under a tight control by means ... -
Glycobiological Regulation of Breast Cancer Invasion
Invasiveness of cancer is the predominant reason behind mortality associated with the disease. Although long under active investigation, fundamental aspects of the early steps of cancer invasion and metastasis are still ... -
Guanylyl Cyclase C Regulation And Pathophysiology
(2015-02-26)The survival of the any living organism depends on its availability to communicate, and a breakdown of cellular signaling can have dire consequences such as uncontrolled cellular proliferations or even cell death. Environmental ...