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    • Molecular Reproduction, Development and Genetics (MRDG)
    • Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
    •   etd@IISc
    • Division of Biological Sciences
    • Molecular Reproduction, Development and Genetics (MRDG)
    • Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
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    Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title

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      • Characterization Of Down Regulated Genes In Astrocytoma 

        Bhanja, Poulomi (2011-07-27)
        Gliomas are the most common primary brain tumors and include astrocytomas, oligodendrogliomas and oligoastrocytomas. Astrocytomas have a high frequency of occurrence as compared to the other gliomas and several studies ...
      • Characterization Of Human Mammary Stem Cells Grown As Mammospheres 

        Dey, Devaveena (2011-01-11)
        Adult stem cells are a small population present within several tissues of an individual, possessing two unique properties: one, the ability to differentiate to give rise to all the cell types of the tissue, and second, the ...
      • Context Dependent Effects of the Transforming Growth Factor-beta Signaling and Role Played by WNT4 in the Activation of Fibroblasts 

        Chopra, Sunita (2018-07-26)
        Transforming growth factor-β (TGF-β) superfamily of cytokines comprises of several members, which can broadly be sub-divided into three classes [TGF-βs, Activin/Nodal, and Bone morphogenetic proteins (BMPs)]. Most members ...
      • Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins 

        Sharma, Ritu (2013-01-28)
        The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ...
      • Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria 

        Nambi, Subhalaxmi (2015-07-17)
        Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ...
      • Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria 

        Vashishtha, Kartika
        Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ...
      • Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans 

        Sandhu, Anjali
        Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ...
      • Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation 

        Sundararaman, Ananthalakshmy (2018-01-07)
        AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ...
      • Development of 3D model and understanding translational regulation of breast cancer 

        Manjunath, Sathish
        Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ...
      • Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants 

        Madan, Aditi (2018-05-23)
        Muscle contraction is a highly fine-tuned process that requires the precise and timely construction of large protein sub-assemblies to form sarcomeres, the individual contractile units. Mutations in many of the genes ...
      • Differential DNA methylation patterns in primary and recurrent glioblastomas : Protumorigenic roles of Tumor Endothelial Marker 8 (TEM8) and ASAP1 genes 

        Kundu, Paramita
        Glioblastomas (GBMs) are clinically aggressive malignant brain tumors in adults with a median survival of 14 months on diagnosis. Therapeutic interventions such as debulking surgeries, chemotherapy, and ionizing radiation, ...
      • Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster 

        Kamble, Ketaki
        Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ...
      • Dissecting the Role of Calcium Binding Proteins in Muscle using Drosophila Indirect Flight Muscles as the Model System 

        Jhonsa, Ruchi
        Muscle development and function are highly synchronized processes that involve simultaneous action of several transcription factors, signalling cascades, kinases and phosphatases, ion channels, structural proteins and ...
      • Effects of Steroid Hormones on Insulin Sensitivity and Lipogenesis: An Insight into the Involvement of the Wnt Signaling Pathway 

        Alex, Neethu Sara
        The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. In this context, the effect of estradiol (E2), progesterone ...
      • Elucidating the Role of Cyclic GMP in Diarrhoea and Intestinal Inflammation 

        Bose, Avipsa
        Cyclic guanosine 3’,5’-monophosphate (cGMP) performs a wide range of functions in various cell types and tissues. The cellular levels of cGMP are maintained by the enzymatic conversion of guanosine 5’-triphosphate (GTP) ...
      • Elucidation of 17β-Estradiol (E2) Role in the Regulation of Corpus Luteum Function in Mammals : Analysis of IGFBP5 Expression during Ea-mediated Actions 

        Tripathy, Sudeshna (2017-12-12)
        Corpus luteum is a transient endocrine structure formed from the ruptured ovarian follicle. Its main function is to secrete P4, a pro-gestational hormone, essential for establishment and maintenance of pregnancy in mammals. ...
      • Embryonic Expression of Cytokines: Functional Role of Il-1β During Blastocyst Hatching 

        Pathak, Madhulika
        The detailed investigation on the embryo-endometrial cytokine expression, in both mouse and hamster, was carried out during the peri-hatching development and it is described in chapter 2. We hypothesize that, for a ...
      • Epigenetic Regulators Of Development In The Social Amoeba Dictyostellium Discoideum : The Roles Played By Histone Deacetylases And Heat Shock Protein 90 

        Sawarkar, Ritwick (2011-01-20)
        The major evolutionary transition from single-celled to multicellular life is believed to have occurred independently of the main metazoan lineages in the cellular slime moulds, of which Dictyostelium discoideum is the ...
      • Epithelial-to-mesenchymal transition and cellular cooperation in cancer progression: Novel roles for AMPK 

        Deshpande, Neha Umakant
        Epithelial-mesenchymal transition (EMT) is a developmental program hijacked by cancer cells to facilitate metastasis —a multi-step process involving the spread of cancer cells from the primary tumor site and culminating ...
      • Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling 

        Khan, Imran (2015-08-19)
        Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies ...

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