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    • Molecular Reproduction, Development and Genetics (MRDG)
    • Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
    •   etd@IISc
    • Division of Biological Sciences
    • Molecular Reproduction, Development and Genetics (MRDG)
    • Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
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    Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title

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      • Activation Of Glycoprotein Hormone Receptors : Role Of Different Receptor Domains In Hormone Binding And Signaling 

        Majumdar, Ritankar (2014-07-16)
        The glycoprotein hormones, Luteinizing Hormone (LH), human Chorionic Gonadotropin (hCG), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH) are heterodimeric proteins with an identical α-subunit ...
      • Activin and TGF-β signaling: Differential role of a Serine/Threonine phosphate in the regulation of SMAD2 activity 

        Gautam, Srishti
        Activins are the most prominent members of the Activin/Inhibin branch of the TGF-β superfamily. Similar to TGF-β, they play an essential role in regulating multiple physiological processes such as development, reproductive ...
      • Ageing associated altered host response to bacterial infection 

        Fernandes, Sheryl Erica
        Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ...
      • Allosteric Regulation Of Proteins In The Cyclic GMP Signal Transduction Pathway 

        Biswas, Kabir Hassan (2013-02-19)
      • Aromatic Beta-Glucoside Utilization In Shigella Sonnei : Comparison With The Escherichia Coli Paradigm 

        Desai, Stuti (2010-12-01)
        The aromatic beta-glucosides of plant origin, salicin and arbutin, serve as carbon sources for the sustenance of bacteria when ‘preferred’ sugars are absent in the environment. In the family Enterobacteriaceae, there are ...
      • Biochemical and functional characterisation of cyclic AMP-binding, universal stress proteins from mycobacteria 

        Banerjee, Arka
        The genus Mycobacterium harbours several pathogenic species, including M. tuberculosis, the causative agent of tuberculosis, which alone is responsible for nearly 1.3 million deaths globally every year. Understanding the ...
      • Biochemical And Functional Characterization Of Evolutionarily Conserved Metallophosphoesterases The 239FB/AB Family 

        Tyagi, Richa (2010-12-30)
        With the advent of large scale genome sequencing efforts along with more sophisticated methods of genetic mapping, a number of loci have been identified that are associated with human diseases. Intriguingly, many genes ...
      • Biochemical and functional characterization of the enigmatic MPPED1/MPPED2 metallophosphodiesterases 

        Gupta, Kirti
        Evolutionarily conserved genes in nature have been known to perform critical functions inside the cell. Earlier bioinformatic analysis performed in our laboratory identified mammalian orthologs of Rv0805, a novel class III ...
      • Biochemical and Functional Characterization of the Mycobacterial PdtaS-PdtaR Two Component System 

        Hariharan, Vignesh Narayan
        Two-Component Systems (TCSs) are primarily prokaryotic modes of cell signaling involving a receptor sensor kinase (SK) that senses stimuli and a response regulator (RR) that effects a response, usually at the level of ...
      • Biochemical and Functional Studies on the Evolutionarily Conserved MPPED1/MPPED2 Protein Family 

        Janardan, Vishnu (2018-05-16)
        A large number of evolutionarily conserved genes have been identified by comparative genomics approaches. However, a considerable fraction of these genes lack functional characterization despite the availability of several ...
      • Biochemical and structural studies to provide insights into initiator tRNA delivery by eIF2A in noncanonical translation initiation 

        Parida, Bijayalaxmi
        Eukaryotic initiation factor 2A (eIF2A), a non-canonical translation initiation factor, delivers initiator tRNA (tRNAi) onto the 40S ribosomal subunit in a codon-dependent and GTP-independent manner, unlike the canonical ...
      • Characterization Of Down Regulated Genes In Astrocytoma 

        Bhanja, Poulomi (2011-07-27)
        Gliomas are the most common primary brain tumors and include astrocytomas, oligodendrogliomas and oligoastrocytomas. Astrocytomas have a high frequency of occurrence as compared to the other gliomas and several studies ...
      • Characterization Of Human Mammary Stem Cells Grown As Mammospheres 

        Dey, Devaveena (2011-01-11)
        Adult stem cells are a small population present within several tissues of an individual, possessing two unique properties: one, the ability to differentiate to give rise to all the cell types of the tissue, and second, the ...
      • Context Dependent Effects of the Transforming Growth Factor-beta Signaling and Role Played by WNT4 in the Activation of Fibroblasts 

        Chopra, Sunita (2018-07-26)
        Transforming growth factor-β (TGF-β) superfamily of cytokines comprises of several members, which can broadly be sub-divided into three classes [TGF-βs, Activin/Nodal, and Bone morphogenetic proteins (BMPs)]. Most members ...
      • Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins 

        Sharma, Ritu (2013-01-28)
        The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ...
      • Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria 

        Nambi, Subhalaxmi (2015-07-17)
        Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ...
      • Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria 

        Vashishtha, Kartika
        Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ...
      • Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans 

        Sandhu, Anjali
        Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ...
      • Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation 

        Sundararaman, Ananthalakshmy (2018-01-07)
        AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ...
      • Development of 3D model and understanding translational regulation of breast cancer 

        Manjunath, Sathish
        Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ...

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