Browsing Molecular Reproduction, Development and Genetics (MRDG) by Title
Now showing items 19-38 of 138
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Deciphering the Mechanisms of AMPK Activation upon Anchorage- Deprivation
(2018-01-07)AMP-activated protein kinase (AMPK) is a key regulator of energy homeostasis in cells. It has been implicated as a therapeutic target for various metabolic diseases like type II diabetes and obesity. However, its role in ... -
Development of 3D model and understanding translational regulation of breast cancer
Breast cancer is the most common cancer among women in India and worldwide. It is a highly heterogeneous disease caused by several genetic and epigenetic alterations in mammary epithelial cells. Both inter- and intra-patient ... -
Development of patient-derived tumor models toward understanding disease biology and drug screening
Cancer is a complex disease of uncontrolled cell proliferation, which cripples the normal functioning of tissues. According to GLOBOCAN 2020, an estimated 19.3 million new cancer cases and around 10 million cancer deaths ... -
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
(2018-05-23)Muscle contraction is a highly fine-tuned process that requires the precise and timely construction of large protein sub-assemblies to form sarcomeres, the individual contractile units. Mutations in many of the genes ... -
Differential DNA methylation patterns in primary and recurrent glioblastomas : Protumorigenic roles of Tumor Endothelial Marker 8 (TEM8) and ASAP1 genes
Glioblastomas (GBMs) are clinically aggressive malignant brain tumors in adults with a median survival of 14 months on diagnosis. Therapeutic interventions such as debulking surgeries, chemotherapy, and ionizing radiation, ... -
Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster
Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ... -
Dissecting the Role of Calcium Binding Proteins in Muscle using Drosophila Indirect Flight Muscles as the Model System
Muscle development and function are highly synchronized processes that involve simultaneous action of several transcription factors, signalling cascades, kinases and phosphatases, ion channels, structural proteins and ... -
Effects of Steroid Hormones on Insulin Sensitivity and Lipogenesis: An Insight into the Involvement of the Wnt Signaling Pathway
The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. In this context, the effect of estradiol (E2), progesterone ... -
Elucidating the Role of Cyclic GMP in Diarrhoea and Intestinal Inflammation
Cyclic guanosine 3’,5’-monophosphate (cGMP) performs a wide range of functions in various cell types and tissues. The cellular levels of cGMP are maintained by the enzymatic conversion of guanosine 5’-triphosphate (GTP) ... -
Elucidation of 17β-Estradiol (E2) Role in the Regulation of Corpus Luteum Function in Mammals : Analysis of IGFBP5 Expression during Ea-mediated Actions
(2017-12-12)Corpus luteum is a transient endocrine structure formed from the ruptured ovarian follicle. Its main function is to secrete P4, a pro-gestational hormone, essential for establishment and maintenance of pregnancy in mammals. ... -
Embryonic Expression of Cytokines: Functional Role of Il-1β During Blastocyst Hatching
The detailed investigation on the embryo-endometrial cytokine expression, in both mouse and hamster, was carried out during the peri-hatching development and it is described in chapter 2. We hypothesize that, for a ... -
Epigenetic Regulators Of Development In The Social Amoeba Dictyostellium Discoideum : The Roles Played By Histone Deacetylases And Heat Shock Protein 90
(2011-01-20)The major evolutionary transition from single-celled to multicellular life is believed to have occurred independently of the main metazoan lineages in the cellular slime moulds, of which Dictyostelium discoideum is the ... -
Epithelial-to-mesenchymal transition and cellular cooperation in cancer progression: Novel roles for AMPK
Epithelial-mesenchymal transition (EMT) is a developmental program hijacked by cancer cells to facilitate metastasis —a multi-step process involving the spread of cancer cells from the primary tumor site and culminating ... -
Establishment of a knock-in mouse model expressing a hypomorphic variant of receptor guanylyl cyclase C
Receptor guanylyl cyclase C (GC-C, gene GUCY2C) is expressed on the apical surface of the intestinal epithelial cells and gets activated by the endogenous ligands guanylin and uroguanylin. Heat-stable enterotoxin (ST) ... -
Etiopathology Of Oral Submucous Fibrosis : Role Of Areca Nut Constituents And Transforming Growth Factor-β Signalling
(2015-08-19)Oral Submucous Fibrosis (OSF) is a chronic inflammatory disease resulting in progressive fibrosis of the oral tissues that can cause difficulty in chewing, swallowing, speaking, and mouth opening. Epidemiological studies ... -
Evaluation of Cytogenotoxic Potential and Embryotoxicity of KRS Cauvery River Water in Zebrafish (Danio Rerio)
Pollutants and other forms of environmental stress (lifestyle and social behaviour) are of global concern due to significant adverse effects on human health. The term "exposome" has emerged as a concept in environmental ... -
Evolution Of New Metabolic Functions By Mutations In Pre-Existing Genes : The chb Operon Of Escherichia Coli As A Paradigm
(2009-07-02)Escherichia coli has the ability to respond to stress such as starvation in a very efficient manner. Under conditions of starvation wherein a novel substrate is provided as a sole nutritional source, Spontaneous mutants ... -
Exploring the Evolution of Cellobiose Utilization in Shigella Sonnei And the Conservation of ChbG Orthologs in Eukaryotes
(2017-10-11)The chb operon constitutes the genes essential for utilization of chitooligosaccharides in Escherichia coli and related species. The six genes of the operon code for a transcriptional regulator (ChbR) of the operon, a ... -
Expression Profiling Of Genes Regulated By TGF-β : Role Of Multiple Signaling Pathways
(2009-05-12)Transforming growth factor-β (TGF-β) is the proto-type member of a super family of secreted proteins comprised of several structurally related, but functionally divergent proteins like the BMP, activin, inhibin, mullerian ... -
Functional Analysis Of Primary Microcephaly Gene Product ASPM
(2013-06-20)Autosomal recessive primary microcephaly (MCPH) is defined by congenital microcephaly and associated mental retardation with head circumference of the affected individual at least 3 standard deviations below age- and ...