Browsing Division of Biological Sciences by Title

Mutational sensitivity of CcdB mutants in their native operonic context

Bajaj, Priyanka

Determining the precise effects of thousands of point mutants on protein structure, stability, and activity is a challenging task. Chapter 1 introduces how next-generation sequencing technologies exploit phenotypic screens ...

Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris

Sahu, Umakant (2018-03-01)

The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive ...

Mycobacterium Leprae RecA Intein : A LAGLIDADG Homing Endonuclease, Displays A Unique Mode Of DNA Binding And Catalysis Compared To A Canonical LAGLIDADG Homing Enzyme

Singh, Pawan (2010-09-30)

Mobile genetic elements are DNA sequences that move around to different positions within one genome or between different genomes. Mobile DNA elements were initially considered as selfish DNA sequences parasitizing the ...

Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins

Manjunath, G P (2011-04-06)

Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles ...

Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors

Guhan, N (Indian Institute of Science, 2005-05-10)

Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an ...

Network Heterogeneities, Intrinsic Plasticity and Decorrelation in the Dentate Gyrus

Mishra, Poonam

A central premise for research in neuroscience is to mechanistically decipher the physiological roles of the brain in effectuating learning and memory. The tripartite framework that is at the core of learning and memory ...

Neural Correlates and Behavioral Underpinnings of Remote Memories during Systems Consolidation

Singh, Aditya

Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ...

Neural Mechanisms underlying the planning of sequential saccades

Basu, Debaleena

Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ...

New Active Site Fold And The Role Of Metal Ions In Structure Function Relationship Of A Promiscuous Endonuclease - R.KpnI

Saravanan, M (2010-07-08)

Bacteria employ survival strategies to protect themselves against foreign invaders, including bacteriophages. The ‘immune system’ of bacteria relies mostly on restriction-modification (R-M) systems. The primary role of R-M ...

New Anticancer Secondary Metabolites from an Endophytic Fungus Chaetomium Nigricolor Isolated from Catharanthus Roseus : Structural Elucidation and Molecular Mechanism Underlying Anticancer Effects

Geethanjali, D (2018-06-13)

Cancer has become a major health problem due to its high rate of morbidity and mortality. Severe side effects associated with most of the available anticancer drugs and the development of the drug resistant cells are the ...

New insights into the role of condensin in Saccharomyces cerevisiae

Lakshmi, Mahendrawada R

Structural Maintenance of Chromosomes (SMC) complexes are highly conserved from prokaryotes to eukaryotes. Saccharomyces cerevisiae has six SMC proteins which form three SMC-complexes in association with non-SMC subunits ...

Newer Insights On Structure, Function And Regulation Of Dps Protein From Mycobacterium smegmatis

Chowdhury, Rakhi Pait (2010-12-29)

The first chapter will provide an introduction to the physiology, pathogenesis and biology of mycobacteria. Host-pathogen interactions, different modes of resistance of the bacteria, adaptations for survival under nutrient ...

NMR Solution Structures of Human γC-Crystallin & the Intrinsically Disordered Viral Genome Linked Protein in the Free & Bound Form

Dixit, Karuna (2018-02-14)

This thesis describes the tertiary structures and dynamic studies of two protein systems. The first is human γC -crystallin protein, which is present in the nucleus of the human eye lens and the other is the plant viral ...