Browsing Division of Biological Sciences by Title
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Achieving oral bioavailability of therapeutic macrocyclic peptides by bridging backbone chemistry with pharmacokinetics
Full text embargo up to Dec 11, 2026 Macrocyclic peptides are emerging as very potential candidates for drug development. Due to the advancement in display technologies, macrocycles can target undruggable proteins. These ... -
Acoustic Signals, Mate Choice And Mate Sampling Strategies in a Field Cricket
(2017-10-05)Acoustic communication in orthopterans and anurans provides a suitable model system for studying the evolutionary mechanisms of sexual selection mainly because males use acoustic signals to attract females over long distances ... -
Activation Of Glycoprotein Hormone Receptors : Role Of Different Receptor Domains In Hormone Binding And Signaling
(2014-07-16)The glycoprotein hormones, Luteinizing Hormone (LH), human Chorionic Gonadotropin (hCG), Follicle Stimulating Hormone (FSH) and Thyroid Stimulating Hormone (TSH) are heterodimeric proteins with an identical α-subunit ... -
Activin and TGF-β signaling: Differential role of a Serine/Threonine phosphate in the regulation of SMAD2 activity
Activins are the most prominent members of the Activin/Inhibin branch of the TGF-β superfamily. Similar to TGF-β, they play an essential role in regulating multiple physiological processes such as development, reproductive ... -
Acyclic peptides as conformational models
Proteins and polypeptides play multi?faceted functional roles in the living organism. Numerous biological processes are controlled by these biomolecules. Hence, there is widespread interest in understanding the structure, ... -
Adjunct Therapy with Curcumin for the Treatment of Malaria : Studies in a Murine Model
(2018-05-16)Malaria accounts for 198 million cases worldwide; with a high mortality rate. 584000 deaths were reported in 2013. Malaria is a re-emerging disease globally due to drug resistance, parasite recrudescence and non-availability ... -
Ageing associated altered host response to bacterial infection
Chapters in which I have elucidated and elaborately described how senescence alters the cellular response to infection, here I demonstrate how senescence in multiple tissues simultaneously contribute to pathogen spread and ... -
Algorithms for Investigating, Decoding and Designing ligand recognition sites in proteins - A Structural Bioinformatics Approach to Studying Protein Function
All physical processes in living organisms are driven by specific biomolecular interactions. Elucidating the characteristics of biomolecular interactions between proteins and their respective small molecule ligands can ... -
Allergens form parthenium hysterophorus clinical and immunological studies
The South American weed Parthenium hysterophorus, which was accidentally introduced into India in 1956, has successfully colonized several parts of the country. Being an alien weed, its uninhibited growth is posing ... -
Altered conformations in natural DNA: Studies on supercoiled form V DNA
The double helical structure of DNA proposed by Watson and Crick, which led to the development of modern biology, was assumed to be a uniform right-handed helix. However, in recent years, the sequence-dependent conformational ... -
Altering DNA topology in mycobacteria: impact of perturbation of DNA gyrase on physiology and gene expression
In the current dissertation, efforts have been made to probe the in vivo role of DNA gyrase to determine its importance in the growth, physiology and gene expression in mycobacteria. In this dissertation, the role of DNA ... -
Alternate Fates of tRNAs in Initiation and Elongation
Protein synthesis in all organisms utilizes a special tRNA called the initiator tRNA. Initiator tRNAs take part in the initiation step of protein synthesis by their direct binding to the P‐site of the ribosome. The other ... -
Amylases From A Thermophilic Fungus Thermomyces Lanuginosus Iisc 91 :Their Purification And Properties
(Indian Institute of Science, 2005-04-06)A knowledge of molecular properties and structure of heat-stable enzymes is important for the understanding of basic principles governing thermo stability of proteins and evolution of life at high temperatures. Information ...