Browsing Division of Biological Sciences by Title
Now showing items 940-959 of 1426
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Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an organism. Dysregulation in the process of wound healing leads to the production of excess extracellular matrix leading to fibrosis. ... -
Role of Sirtuin6 in the maintenance of cardiac lysosomal homeostasis
The response to cardiac stress can be divided into two phases- an initial adaptive compensatory phase followed by a maladaptive decompensatory phase. Protein homeostasis in cardiomyocytes has been observed to behave ... -
Role of TCP transcription factors in seedling development, leaf morphogenesis and senescence in Arabidopsis thaliana
The TCP gene family encodes non-canonical bHLH transcription factors that act as key regulatory molecules in diverse developmental processes in plants including organ morphogenesis, plant architecture, leaf maturation, and ... -
Role of TCP4 Transcription Factor in the Maturation Program of Arabidopsis Life Cycle
(2018-07-28)TCP4 as an integrator of key developmental events A striking aspect of plant life is their sedentary life-style. Though it relieves them of the obligation of forming a complex body organization, it exposes them to ... -
Role of the ELONGATED GYNOPHORE/ELONGATA2 Protein in Fruit and Root Development in Arabidopsis Thaliana
(2018-06-23)In order to identify new players in fruit development, a forward genetic screen was performed on EMS mutagenized plants. A mutant named elongated gynophore (egy) was identified in the M2 population based on altered fruit ... -
Role of the miR319-JAW-TCP module in the growth and development of the female reproductive organ in Arabidopsis thaliana
Named after their founding members TEOSINTE BRANCHED1, CYCLOIDEA, and PROLIFERATING CELL FACTORs, the TCP transcription factors have been investigated for their diverse role in plant growth and development. The five ... -
Role of the unstructured N-terminal region and interacting proteins on the function of Mycobacterium tuberculosis σA
A distinctive feature of the bacterial RNA polymerase is the modular organization. The core of this enzyme, comprised of a dimer of the α subunit assembles with the β, β', and ω subunit. The core RNA polymerase enzyme ... -
Role of VILAMBIT Genes Controlling Flowering Time and Jasmonic Acid Signaling in Arabidopsis
(2018-08-14)The transition to flowering is an important decision for plants since seed-setting and the survival of the progeny depend on the environmental conditions prevalent during this transition. Therefore, to ensure maximum ... -
Role of Water in plasticity and action of proteins. The crystal structures of Monoclinic Lysozyme at different levels of Hydration
This thesis seeks to elucidate the role of hydration in the plasticity, stability, and action of lysozyme, and the work reported therein forms part of a long-range programme involving water-mediated transformations, ... -
Roles of Drosophila Beadex and CG9650 in the development and functioning of the larval neuromuscular junctions
In eukaryotes, all voluntary and involuntary actions like, cognition, learning & memory, voluntary movements, feeding, etc., are coordinated by the employment of neuronal circuitry that transmits the signal from the ... -
Roles of N10-formyl-tetrahydrofolate (N10-fTHF), ribosomal large subunit pseudouridine synthase D (RluD), and transcription-translation coupling in the fidelity of translation initiation in Escherichia coli
Protein synthesis is a fundamental process in gene expression. It involves four basic steps – initiation, elongation, termination, and ribosome recycling in bacteria. However, the step of initiation is the most regulated ... -
Roles of Protein Acetylation in the Human Pathogen Helicobacter pylori
Helicobacter pylori is a gram-negative epsilon proteobacterium infecting half of the world population. H. pylori is a naturally competent bacterium with a huge repertoire of Restriction-Modification (RM) systems. The ... -
Roles of the ribosomal protein uS12 and the initiation factor 3 in the maintenance of fidelity of translation in Escherichia coli
The flow of genetic information within biological systems according to the central dogma of molecular biology entails protein synthesis as the last step towards deciphering the message encrypted in the genetic code in ... -
Rotavirus Viroplasm Structure (VS) : The First Insights into the Architectural Assembly of the Viral and Host Factors in the VS"
Rotavirus is a major cause of acute gastroenteritis in infants and young children and responsible for approximately 453,000 infantile deaths per year. Rotaviruses are non-enveloped RNA viruses belonging to the Reoviridae ... -
Rv0805, a novel regulator of central carbon metabolism and cell envelope properties in mycobacteria
Metabolic flexibility is one of the key factors that underpin mycobacterial physiology and pathogenesis. During infection, mycobacteria shift towards utilising host-derived fatty acids, lipids, cholesterol and cholesterol-esters. ... -
Saccharomyces cerevisiae meiosis-specific hop1 protein and its putative zinc-finger motif promote synapsis between double-stranded DNA helices : a role for guanine quartets in ininterstitial pairing
Meiosis is an evolutionarily conserved biological process that allows genetic exchange between paternal and maternal genomes in all sexually reproducing species. The hallmark features of meiosis include pairing of homologous ... -
Salmonella Pathogenesis in Dendritic Cells : Stealthy Approach Against Adaptive Immune Response
Synopsis of work done by Mayuri Gogoi (SR No. 10-09-00-10-31-11-1-08534) for the award of Ph.D. degree in the Faculty of Science, Indian Institute of Science, Bangalore, India. Thesis title: Salmonella pathogenesis in ... -
Scanning mutagenesis studies of HIV-1 Env immunogenicity and structure
Human Immunodeficiency Virus type 1 (HIV-1) is the etiological agent of Acquired Immunodeficiency Syndrome (AIDS). AIDS is a global pandemic with 36.7 million people living with HIV-1 all over the world and approximately ...