Browsing Division of Biological Sciences by Title
Now showing items 934-953 of 1425
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Role of Sirt2 in Stress-induced Muscle Atrophy
Skeletal muscle is one of the essential organs in our body, responsible for various functions such as locomotion, transport, protein storage, and thermoregulation. Under certain pathological conditions, there is a reduction ... -
ROLE OF SIRT6 AND PARP-1 IN MUSCLE HOMEOSTASIS
Sirtuins and PARPs are stress responsive family of proteins regulating genome instability, inflammation, aging-related diseases and energy metabolism. Both sirtuins and PARPs are NAD+ enzymes with deacetylase and ADP-ribose ... -
Role of SIRT6 in Myofibroblast Cell Death
(2018-01-10)Cardiovascular diseases are one of the leading causes of mortality. A common denominator across most of the cardiovascular diseases like diabetic cardiomyopathy, hypertrophic cardiomyopathy, myocardial infarction and dilated ... -
Role of SIRT6 in the Regulation of Glucose Metabolism and Fatty Acid Uptake in Heart
The adult heart heavily relies on fatty acid for most of its energy supplies. The heart derives most of the fatty acid from circulation. Hence, fatty acid uptake forms a crucial step in cardiac metabolism. Studies have ... -
Role of SIRT6 in the regulation of mTOR signalling and global protein synthesis
Cells are constantly engaged in the process of making and breaking proteins in a highly organized manner. However, protein synthesis is an energetically expensive process and often competes with other cellular repair and ... -
Role of Sirtuin 2 in the development of tissue fibrosis
Wound healing is a crucial physiological process required for the healthy lifespan of an organism. Dysregulation in the process of wound healing leads to the production of excess extracellular matrix leading to fibrosis. ... -
Role of Sirtuin6 in the maintenance of cardiac lysosomal homeostasis
The response to cardiac stress can be divided into two phases- an initial adaptive compensatory phase followed by a maladaptive decompensatory phase. Protein homeostasis in cardiomyocytes has been observed to behave ... -
Role of TCP transcription factors in seedling development, leaf morphogenesis and senescence in Arabidopsis thaliana
The TCP gene family encodes non-canonical bHLH transcription factors that act as key regulatory molecules in diverse developmental processes in plants including organ morphogenesis, plant architecture, leaf maturation, and ... -
Role of TCP4 Transcription Factor in the Maturation Program of Arabidopsis Life Cycle
(2018-07-28)TCP4 as an integrator of key developmental events A striking aspect of plant life is their sedentary life-style. Though it relieves them of the obligation of forming a complex body organization, it exposes them to ... -
Role of the ELONGATED GYNOPHORE/ELONGATA2 Protein in Fruit and Root Development in Arabidopsis Thaliana
(2018-06-23)In order to identify new players in fruit development, a forward genetic screen was performed on EMS mutagenized plants. A mutant named elongated gynophore (egy) was identified in the M2 population based on altered fruit ... -
Role of the miR319-JAW-TCP module in the growth and development of the female reproductive organ in Arabidopsis thaliana
Named after their founding members TEOSINTE BRANCHED1, CYCLOIDEA, and PROLIFERATING CELL FACTORs, the TCP transcription factors have been investigated for their diverse role in plant growth and development. The five ... -
Role of the unstructured N-terminal region and interacting proteins on the function of Mycobacterium tuberculosis σA
A distinctive feature of the bacterial RNA polymerase is the modular organization. The core of this enzyme, comprised of a dimer of the α subunit assembles with the β, β', and ω subunit. The core RNA polymerase enzyme ... -
Role of VILAMBIT Genes Controlling Flowering Time and Jasmonic Acid Signaling in Arabidopsis
(2018-08-14)The transition to flowering is an important decision for plants since seed-setting and the survival of the progeny depend on the environmental conditions prevalent during this transition. Therefore, to ensure maximum ... -
Role of Water in plasticity and action of proteins. The crystal structures of Monoclinic Lysozyme at different levels of Hydration
This thesis seeks to elucidate the role of hydration in the plasticity, stability, and action of lysozyme, and the work reported therein forms part of a long-range programme involving water-mediated transformations, ... -
Roles of Drosophila Beadex and CG9650 in the development and functioning of the larval neuromuscular junctions
In eukaryotes, all voluntary and involuntary actions like, cognition, learning & memory, voluntary movements, feeding, etc., are coordinated by the employment of neuronal circuitry that transmits the signal from the ... -
Roles of N10-formyl-tetrahydrofolate (N10-fTHF), ribosomal large subunit pseudouridine synthase D (RluD), and transcription-translation coupling in the fidelity of translation initiation in Escherichia coli
Protein synthesis is a fundamental process in gene expression. It involves four basic steps – initiation, elongation, termination, and ribosome recycling in bacteria. However, the step of initiation is the most regulated ... -
Roles of Protein Acetylation in the Human Pathogen Helicobacter pylori
Helicobacter pylori is a gram-negative epsilon proteobacterium infecting half of the world population. H. pylori is a naturally competent bacterium with a huge repertoire of Restriction-Modification (RM) systems. The ... -
Roles of the ribosomal protein uS12 and the initiation factor 3 in the maintenance of fidelity of translation in Escherichia coli
The flow of genetic information within biological systems according to the central dogma of molecular biology entails protein synthesis as the last step towards deciphering the message encrypted in the genetic code in ...