Browsing Division of Biological Sciences by Title
Now showing items 913-932 of 1026
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Systemic Profiling of Two Component Signaling Networks in Mycobacterium Tuberculosis
(2018-05-23)Mycobacterium tuberculosis, the causative organism of the disease tuberculosis (TB) in humans, leads to nearly two million deaths each year. This versatile pathogen can exist in highly distinct physiological states such ... -
Systems biology approach to dissect Salmonella-host interactions
Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ... -
A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection
(2018-01-04)Mycobacterium tuberculosis, the etiological agent of tuberculosis, has adapted with the host environment and evolved to survive in harsh conditions in the host. The pathogen has successfully evolved strategies not only to ... -
A systems-level exploration of host responses across the disease spectrum of Tuberculosis and COVID-19
The host immune system orchestrates a defense mechanism against any invading pathogen with a combination of many mechanisms including antibody production, T-cell response, and memory response. The manner and extent of host ... -
T Cell Epitopes Of PE And PPE Family Of Proteins Of Mycobacterium Tuberculosis And Analysis Of Their Vaccine Potential
(2010-03-09)One-third of the world’s population is latently infected with Mycobacterium tuberculosis, which causes over 2 million deaths every year. The current live attenuated vaccine, Bacille Calmette-Guerin (BCG), protects against ... -
Target Genes and Pathways Regulated by OsMADSI during Rice Floret Specification and Development
(2018-04-12)In angiosperms, specialized reproductive structures are borne in flowers to ensure their reproductive success. After the vegetative growth, plants undergo reproductive phase change to produce flowers. Floral meristems (FMs) ... -
Targeting Gonadotropins to the Dendritic Cells : A Novel Strategy for Animal Immunocontraceptive Vaccine
(2018-05-09)Contraception through a vaccine has been a very attractive proposition and several attempts were made in the past. To achieve contraception through immunological means, several points need to be considered. First, the ... -
Targeting RAD51C Pathological Mutants by Synthetic Lethality and Extended Functions of RAD51C/XRCC3 in Mitochondrial Genome Maintenance
To counteract the potentially calamitous effects of genomic instability in the form of double-strand breaks (DSBs), cells have evolved with two major mechanisms. First, DNA non¬homologous end joining (NHEJ) which requires ... -
Targeting The CD4 Biniding Site In HIV-1 Immunogen Design
(2016-11-15)Over three decades have passed since the discovery of HIV-1, yet an AIDS vaccine remains elusive. The envelope glycoprotein of HIV-1 gp120, is the most exposed protein on the viral surface and thus serves as an important ... -
Temporal patterns of neural activity governing spatial representation in the hippocampus
Space is a fundamental substrate for animal interactions with the external world. The hippocampus, a region deep within the temporal lobe of mammalian brains, is a multisensory structure that has been heavily implicated ... -
Territorial and mating strategies of males in a lekking population of blackbuck Antilope cervicapra
Territoriality associated with lek-mating systems is unique in that males defend small, heavily clustered territories that lack resources usually thought to attract females, such as food and water. Females visit these male ... -
Thermodynamic Characterization Of Wild Type And Mutants Of The E.coli Periplasmic Binding Proteins LBP, LIVBP, MBP And RBP
(2009-03-13)Native states of globular proteins typically show stabilization in the range of 5 to 15 kcal/mol with respect to their unfolded states. There has been a considerable progress in the area of protein stability and folding ... -
Theta-band Spectral Selectivity and Gamma-range Coincidence Detection in Spike Initiation Dynamics of Hippocampal Pyramidal Neurons
In the pursuit to understand information processing in the brain, a general question that is often posed is: What is the neuron encoding? This is addressed by assessing feature selectivity in sensory neurons, which informs ... -
Through the looking glass: Phoresy as seen in the light of mutualism
Phoresy is the dispersal of small organisms on larger ones to move out of an unfavourable habitat. Although these interactions are transient, they can form tight links with mutualistic interactions if the phoretic organisms ... -
Topoisomerase i from mycobacterium tuberculosis : Dynamics of enzyme function and inhibitor development
Inside the bacterial cell, the genetic material is maintained in a negatively supercoiled state within a compact space. The supercoiling of the genome undergoes topological perturbations during a variety of cellular processes ... -
Topoisomerases from Mycobacteria : Insights into the Mechanism, Regulation and Global Modulatory Functions
(2018-03-09)The eubacterial genome is maintained in a negatively supercoiled state which facilitates its compaction and storage in a small cellular space. Genome supercoiling can potentially influence various DNA transaction processes ... -
Topology-based Sequence Design For Proteins Structures And Statistical Potentials Sensitive To Local Environments
(2013-01-17)Proteins, which regulate most of the biological activities, perform their functions through their unique three-dimensional structures. The folding process of this three dimensional structure from one dimensional sequence ... -
Towards precision medicine to detect, characterize and treat liver cancer: Large-scale data analyses using genome-wide networks
In summary, various systems biology approaches were applied to identify a potential genesignature set to monitor CLD progression which can help in the early detection of HCC. An unbiased analysis of metabolic alterations ...