Browsing Division of Biological Sciences by Title
Now showing items 901-920 of 1026
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Substrate Specificity Determinants of Class III Nucleotide Cyclases
(2018-07-31)Cyclic AMP and cyclic GMP (cAMP and cGMP) are important second messengers in key signal-transduction pathways that mediate various physiological functions in bacteria and eukaryotes. Adenylyl Cyclases (ACs) and Guanylyl ... -
Subthreshold Conductances Regulate Theta-Frequency Local Field Potentials and Spike Phase
(2018-02-21)Local field potentials (LFPs), extracellular potentials that reflect localized electrical activity, have long been used as a window to understand the behavioural dependence and mechanistic aspects of brain physiology. A ... -
Super-Resolution Imaging Reveals Localization and Regulation of Nanoscale Machinery Involved in the Amyloidogenic Pathway
Amyloid Precursor Protein (APP) is a key player in Alzheimer’s disease (AD). Despite intuitive insights into differential proteolysis of APP, there is a little understanding of how the amyloidogenic machinery is distributed ... -
Suppression of epileptiform activity by lactate through HCA1 and GIRK channel activation in rat subicular pyramidal neurons
In the present study, we report a lactate-induced hyperpolarization and reduction of epileptiform activity in subicular weak burst firing and regular firing neurons using patch clamp electrophysiology. We showed the ... -
Survival Strategies Of Salmonella Under Host Nitrosative Stress And Its Role In Pathogenesis
(2010-12-07)Chapter: 1 Introduction Genus Salmonella is a Gram-negative rod shaped facultative anaerobic bacteria that can survive inside the host macrophages and cause persistent infection. Salmonella Typhimurium, Salmonella Typhi ... -
Survival Strategies Of SALMONELLA
(2010-08-25)The genus Salmonella includes facultative intracellular pathogens. Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever in humans killing about 2,00,000 people globally every year. Salmonella enterica serovars ... -
Synergistic Influence of Gene Architecture and Promoter Structure on Transcription in Plants : An in silico Analysis
Understanding the structural organisation of genome and insightful information of gene has helped in exploring the regulation and expression of the gene at a molecular and cellular level. In eukaryotes, the gene regulation ... -
Synthesis and Conformational Analysis of Peptides Containing the Gamma Amino Acid Residue Gabapentin
Insertion of amino acid residues into all polypeptide backbones leads to an expanded repertoire of secondary structures. In the present thesis an attempt has been made to explore the conformational properties of the ... -
Systematics And Biogeography Of Scolopendrids Of The Western Ghats, India
(2013-06-25)In this thesis, the biogeography of the centipede family Scolopendridae of the Western Ghats (WG)was studied. First, a novel limited sampling approach to identify putative Gondwanan origin wherein sampling of was confined ... -
Systematics and Comparative Biogeography of Vine Snakes (Genus: Ahaetulla, Family: Colubridae) and Pit vipers (Genus: Trimeresurus, Family: Viperidae) in Peninsular India
The Indian subcontinent is a considered a mega biodiverse region with representative regions belonging to three of the 35 global biodiversity hotspots, including the Western Ghats in Peninsular India and the Eastern ... -
Systematics and Diversification in the Indian Radiation of Hemidactylus Geckos
Understanding the patterns and processes generating biodiversity is fundamental to ecology and evolutionary biology, and studying diversification can give us key insights into this process. In my thesis, I investigate ... -
Systematics, Phylogeny And Acoustic Evolution In Field Crickets (Orthoptera, Grylloidea, Gryllinae)
(2018-03-06)Since several decades, field crickets of the subfamily Gryllinae under order Orthoptera have been used as a model group by researchers working in the field of neuroethology, behavioural ecology and bioacoustics. Subfamily ... -
Systemic Profiling of Two Component Signaling Networks in Mycobacterium Tuberculosis
(2018-05-23)Mycobacterium tuberculosis, the causative organism of the disease tuberculosis (TB) in humans, leads to nearly two million deaths each year. This versatile pathogen can exist in highly distinct physiological states such ... -
Systems biology approach to dissect Salmonella-host interactions
Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ... -
A Systems Biology Approach towards Understanding Host Response and Pathogen Adaptation in Latent Tuberculosis Infection
(2018-01-04)Mycobacterium tuberculosis, the etiological agent of tuberculosis, has adapted with the host environment and evolved to survive in harsh conditions in the host. The pathogen has successfully evolved strategies not only to ... -
A systems-level exploration of host responses across the disease spectrum of Tuberculosis and COVID-19
The host immune system orchestrates a defense mechanism against any invading pathogen with a combination of many mechanisms including antibody production, T-cell response, and memory response. The manner and extent of host ... -
T Cell Epitopes Of PE And PPE Family Of Proteins Of Mycobacterium Tuberculosis And Analysis Of Their Vaccine Potential
(2010-03-09)One-third of the world’s population is latently infected with Mycobacterium tuberculosis, which causes over 2 million deaths every year. The current live attenuated vaccine, Bacille Calmette-Guerin (BCG), protects against ... -
Target Genes and Pathways Regulated by OsMADSI during Rice Floret Specification and Development
(2018-04-12)In angiosperms, specialized reproductive structures are borne in flowers to ensure their reproductive success. After the vegetative growth, plants undergo reproductive phase change to produce flowers. Floral meristems (FMs) ... -
Targeting Gonadotropins to the Dendritic Cells : A Novel Strategy for Animal Immunocontraceptive Vaccine
(2018-05-09)Contraception through a vaccine has been a very attractive proposition and several attempts were made in the past. To achieve contraception through immunological means, several points need to be considered. First, the ... -
Targeting RAD51C Pathological Mutants by Synthetic Lethality and Extended Functions of RAD51C/XRCC3 in Mitochondrial Genome Maintenance
To counteract the potentially calamitous effects of genomic instability in the form of double-strand breaks (DSBs), cells have evolved with two major mechanisms. First, DNA non¬homologous end joining (NHEJ) which requires ...