Browsing Division of Biological Sciences by Title
Now showing items 893-912 of 1026
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A study of extracellular matrix dynamics in epithelial cancer progression with a special focus on ovarian cancer spheroidogenesis
Epithelial ovarian cancer (EOC) is one of the most debilitating gynecological cancers in women worldwide due to its insidious symptoms. The predominant subtype of ovarian cancer: high-grade serous ovarian carcinoma (HGSOC), ... -
Study Of Rpb4, A Component Of RNA Polymerase II As A Coordinator Of Transcription Initiation And Elongation In S. Cerevisiae
(2017-05-24)RNA polymerase II (Pol II) is the enzyme responsible for the synthesis of all mRNAs in eukaryotic cells. As the central component of the eukaryotic transcription machinery, Pol II is the final target of transcription ... -
A Study Of The Roles Played By The Trishanku Gene In The Morphogenesis Of Dictyostelium Discoideum
(2011-02-22)A hallmark feature of Dictyostelium development is the establishment and maintenance of precise cell-type proportions. In the case of D. discoideum, roughly 20% of the cells that aggregate form the stalk while the remaining ... -
A Study On The Mechanism Of Initiator tRNA Selection On The Ribosomes During Translation Initiation And Rescue Of The Stalled Ribosomes By SsrA In Escherichia Coli
(2013-02-07)The studies reported in this thesis describe the work done in the area of translation initiation where a previously unknown role of multiple copies of initiator tRNA in E. coli has been reported. Also the role of SsrA ... -
A Study On The Roles Of The Ras Activation Pathway During Interferonγ Mediated Functional Responses And Acetaminophen-induced Liver Injury In Mice
(2010-12-07)Interferons (IFNs) perform a wide range of biological activities: anti-microbial, anti-proliferative, immunomodulatory etc. The IFN family includes three main classes: Type I, Type II and the recently identified Type III. ... -
Study To Map The Functional Domain Of Glycodelin
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Studying the role of small GTPase Rab14 in the regulation of endosomal function
The endomembrane system and their associated membrane trafficking are fundamental features of eukaryotic cell biology. These processes are regulated by small GTP-binding proteins that acts as molecular switches to ... -
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity
Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ... -
Substrate Specificity Determinants of Class III Nucleotide Cyclases
(2018-07-31)Cyclic AMP and cyclic GMP (cAMP and cGMP) are important second messengers in key signal-transduction pathways that mediate various physiological functions in bacteria and eukaryotes. Adenylyl Cyclases (ACs) and Guanylyl ... -
Subthreshold Conductances Regulate Theta-Frequency Local Field Potentials and Spike Phase
(2018-02-21)Local field potentials (LFPs), extracellular potentials that reflect localized electrical activity, have long been used as a window to understand the behavioural dependence and mechanistic aspects of brain physiology. A ... -
Super-Resolution Imaging Reveals Localization and Regulation of Nanoscale Machinery Involved in the Amyloidogenic Pathway
Amyloid Precursor Protein (APP) is a key player in Alzheimer’s disease (AD). Despite intuitive insights into differential proteolysis of APP, there is a little understanding of how the amyloidogenic machinery is distributed ... -
Suppression of epileptiform activity by lactate through HCA1 and GIRK channel activation in rat subicular pyramidal neurons
In the present study, we report a lactate-induced hyperpolarization and reduction of epileptiform activity in subicular weak burst firing and regular firing neurons using patch clamp electrophysiology. We showed the ... -
Survival Strategies Of Salmonella Under Host Nitrosative Stress And Its Role In Pathogenesis
(2010-12-07)Chapter: 1 Introduction Genus Salmonella is a Gram-negative rod shaped facultative anaerobic bacteria that can survive inside the host macrophages and cause persistent infection. Salmonella Typhimurium, Salmonella Typhi ... -
Survival Strategies Of SALMONELLA
(2010-08-25)The genus Salmonella includes facultative intracellular pathogens. Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever in humans killing about 2,00,000 people globally every year. Salmonella enterica serovars ... -
Synergistic Influence of Gene Architecture and Promoter Structure on Transcription in Plants : An in silico Analysis
Understanding the structural organisation of genome and insightful information of gene has helped in exploring the regulation and expression of the gene at a molecular and cellular level. In eukaryotes, the gene regulation ... -
Synthesis and Conformational Analysis of Peptides Containing the Gamma Amino Acid Residue Gabapentin
Insertion of amino acid residues into all polypeptide backbones leads to an expanded repertoire of secondary structures. In the present thesis an attempt has been made to explore the conformational properties of the ... -
Systematics And Biogeography Of Scolopendrids Of The Western Ghats, India
(2013-06-25)In this thesis, the biogeography of the centipede family Scolopendridae of the Western Ghats (WG)was studied. First, a novel limited sampling approach to identify putative Gondwanan origin wherein sampling of was confined ... -
Systematics and Comparative Biogeography of Vine Snakes (Genus: Ahaetulla, Family: Colubridae) and Pit vipers (Genus: Trimeresurus, Family: Viperidae) in Peninsular India
The Indian subcontinent is a considered a mega biodiverse region with representative regions belonging to three of the 35 global biodiversity hotspots, including the Western Ghats in Peninsular India and the Eastern ... -
Systematics and Diversification in the Indian Radiation of Hemidactylus Geckos
Understanding the patterns and processes generating biodiversity is fundamental to ecology and evolutionary biology, and studying diversification can give us key insights into this process. In my thesis, I investigate ... -
Systematics, Phylogeny And Acoustic Evolution In Field Crickets (Orthoptera, Grylloidea, Gryllinae)
(2018-03-06)Since several decades, field crickets of the subfamily Gryllinae under order Orthoptera have been used as a model group by researchers working in the field of neuroethology, behavioural ecology and bioacoustics. Subfamily ...