Browsing Division of Biological Sciences by Title
Now showing items 823-842 of 1514
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Physiological And Exogenous Means of Regulating DNA Damage Response : Insights into Mechanisms of DNA Repair And Genomic Instability
(2017-09-23)Maintenance of genomic integrity with high fidelity is of prime importance to any organism. An insult which may result in compromised genome integrity is prevented or its consequences are monitored by advanced cellular ... -
Physiological Importance Of DNA Repair In Mycobacteria
(2013-01-16) -
Physiological Interactions between Neuronal Active Conductances And Inositol Trisphosphate Receptors in Neurons and Astrocytes
(2018-07-23)Intricate interactions among constituent components are defining hallmarks of biological systems and sculpt physiology across different scales spanning gene networks to behavioural repertoires. Whereas interactions among ... -
Physiological Role of Arr, an ADP-ribosyltransferase in Mycobacterium smegmatis
The studies reported in this thesis address the physiological role of an antibiotic resistance gene arr, followed by establishment of the arr knockout strains (generated during the investigation) for drug testing and ... -
Physiological Role of Folate Dehydrogenase in One Carbon Metabolism of Escherichia Coli
(2018-06-08)Thesis addresses the physiological role of formyl tetrahydrofolate synthetase (Fhs) and bifunctional folate dehydrogenase (FolD) in folate mediated one carbon metabolism in bacteria. Thesis consists of 5 chapters. First ... -
Physiological Significance of Stop Codon Readthrough
Regulation of translation, the process by which ribosomes synthesize proteins from mRNAs, is critical to maintain cellular proteostasis. Dysregulation of translation is implicated in several neurodegenerative, metabolic, ... -
Physiological significance of tRNA sequences and modifications in regulation of the bacterial growth
Transfer RNA or tRNA is one of the vital components of translation machinery where it acts as an adaptor molecule to bring amino acid to the ribosome in response to the genetic code in mRNA. Its key role is to decode the ... -
A place for everything and everything in its place: Spatial organization of wasps on the nests of the primitively eusocial paper wasp Ropalidia marginata
In my thesis, I found that queens and workers in the primitively eusocial paper wasp Ropalidia marginata use space on their nests non-randomly with a majority of individuals showing spatial fidelity to small core areas, ... -
Plasma transport and functional aspects of vitamin a in the avian species
Vitamin A is indispensable for growth, vision and reproduction. A relationship between vitamin A deficiency and a higher incidence of cancer was suggested more than 50 years ago. The role of vitamin A in biochemical processes ... -
Plasticity of Intrinsic Excitability in Fast Spiking Interneurons of the Dentate Gyrus & Its Implications for Neuronal Network Dynamics
Inhibitory GABAergic neurons, although forming a minor proportion of the neuronal population in the central nervous system, have been reported to be crucial for different physiological states of the brain. Among the vast ... -
Plasticity Paradigms: Navigating Protein Conformational Dynamics and Phenotypic Variability in Biological Systems
The complex dynamics and responses of biological systems to environmental cues are shaped by their inherent plasticity and adaptability. This biological plasticity, operational at multiple levels - ranging from the molecular ... -
Plug in the pupa: Insights into the evolutionary ecology of the complex life cycle of Aedes aegypti
Multiple traits, including antipredator responses, foraging behaviour, development rate and fecundity, contribute towards an organism’s fitness. These diverse traits interact through shared resources allocated to maximise ... -
Post translational modification and DNA binding studies with two nucleoid associated proteins of Mycobacterium tuberculosis
Genome in prokaryotes is found in a small confinement called nucleoid. The nucleoid compaction is brought about by the combined action of topoisomerases and Nucleoid associated proteins (NAPs). Topoisomerases maintain ... -
Post-transcriptional regulation of the tumor suppressor gene TSC1 and its relevance in Oral Squamous Cell Carcinoma
Oral cancer or oral squamous cell carcinoma (OSCC) is a subset of head and neck cancer (excluding non-melanoma skin cancer), with an estimated 354,864 new cases and 177,384 deaths reported annually. India accounts for 34% ...