Browsing Division of Biological Sciences by Title
Now showing items 751-770 of 1514
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Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis
(2018-04-18)All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal ... -
Morphological and biochemical studies on some yeasts and fungi
The morphological and biochemical studies of the penicillin producing fungi are described; single spore isolations have been made, methods of assay of the antibiotic are described. An attempt is made to correlate the ... -
Motifs in proteins: Disulfide constraints and their applications to protein engineering and peptide modelling
By carrying out a detailed data analysis of 175 PP motifs in proteins, sequence–structure relationships were identified for linking loops 1–5 residues long. Conformational families were recognized in 1-, 2-, 3-, and 4-residue ... -
Multi-faceted modular interactions in proteins
All living systems are composed of plethora of biomolecules. There are various types of biomolecules such as proteins, DNA, RNA, carbohydrates and metabolites. All the reactions in a biological system involve interactions ... -
Multimodal Duetting and Pair Formation in a Paleotropical False Leaf Katydid, Onomarchus uninotatus
The spectacular diversity in the pair-formation strategies among animal groups has attracted the attention of many over the years. The roots of this diversity lie in the diversity of challenges that males and females face ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ... -
Mutational analysis of Rpb4 and Rpb7 : Insights into their role in transcription and stress response of saccharomyces cerevisiae
The Yeast Saccharomyces cerevisiae as a Model System for Stress Response and Transcription The yeast Saccharomyces cerevisiae is an excellent model system to study the molecular basis of stress response. Apart from its ... -
Mutational sensitivity of CcdB mutants in their native operonic context
Determining the precise effects of thousands of point mutants on protein structure, stability, and activity is a challenging task. Chapter 1 introduces how next-generation sequencing technologies exploit phenotypic screens ... -
Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris
(2018-03-01)The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive ... -
Mycobacterial DNA gyrase : biochemical characterisation and development of a novel gyrase inhibitor
Synopsis DNA gyrase is a unique topoisomerase, as it is the only enzyme capable of introducing negative supercoils into DNA. The enzyme has essential roles in cellular DNA transactions such as DNA replication, transcription, ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Mycobacterium Leprae RecA Intein : A LAGLIDADG Homing Endonuclease, Displays A Unique Mode Of DNA Binding And Catalysis Compared To A Canonical LAGLIDADG Homing Enzyme
(2010-09-30)Mobile genetic elements are DNA sequences that move around to different positions within one genome or between different genomes. Mobile DNA elements were initially considered as selfish DNA sequences parasitizing the ... -
Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins
(2011-04-06)Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles ... -
Mycobacterium smegmatis topoisomerase I : insights into site specific recognition and mechanism of action
Mycobacterium smegmatis TOPOISOMERASE I: INSIGHTS INTO SITE-SPECIFIC RECOGNITION AND MECHANISM OF ACTION The work embodied in this thesis is an attempt to understand the relaxation mechanism catalyzed by Mycobacterium ... -
Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors
(Indian Institute of Science, 2005-05-10)Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an ... -
Network Heterogeneities, Intrinsic Plasticity and Decorrelation in the Dentate Gyrus
A central premise for research in neuroscience is to mechanistically decipher the physiological roles of the brain in effectuating learning and memory. The tripartite framework that is at the core of learning and memory ... -
Neural Correlates and Behavioral Underpinnings of Remote Memories during Systems Consolidation
Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ... -
Neural Mechanisms underlying the planning of sequential saccades
Saccades are rapid eye movements that we continually make (about 2-3 times per second) to look around and scan our visual environment. Though we effortlessly execute saccadic eye movements all the time, they are not just ... -
Neuroimmune Regulation in Caenorhabditis elegans: The Roles of the Amphid Sensory Neurons and Olfaction in Host Immune Responses
The ability of hosts to rapidly sense invading pathogens and mount an appropriate response is paramount for host survival. Pathogens, pervasive in the natural world, present a perpetual threat to host organisms. Examining ... -
Neuronal complex bursts and network information transfer in the hippocampus are robust to biophysical heterogeneities
Biological entities must adopt mechanisms to override the impact of external perturbations to achieve stability and robustness. A crucial feature of biological systems is that they exhibit several forms of heterogeneities ...