Browsing Division of Biological Sciences by Title
Now showing items 710-729 of 1426
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Molecular modelling studies on wheat germ agglutinin-saccharide interactions
Thus, the present study provides many insights into the conformational dynamics of the saccharides in vacuum and in water. It shows that at room temperature, both in vacuum and in water, the sugar ring exhibits limited ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Molecular Phenotyping of Mutations in Guanylyi Cyclase C Associated with Congenital Diarrhea
(2018-02-28)Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). ST is acknowledged ... -
A molecular systems approach to unravel mechanisms and targets in antifolate-resistant bacteria and cancers
Antifolates such as trimethoprim (TMP) and methotrexate (MTX) widely used for treating bacterial infections and certain cancers respectively, inhibit dihydrofolate reductase (DHFR) in the folate pathway. However, the use ... -
Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis
(2018-04-18)All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal ... -
Motifs in proteins: Disulfide constraints and their applications to protein engineering and peptide modelling
By carrying out a detailed data analysis of 175 PP motifs in proteins, sequence–structure relationships were identified for linking loops 1–5 residues long. Conformational families were recognized in 1-, 2-, 3-, and 4-residue ... -
Multi-faceted modular interactions in proteins
All living systems are composed of plethora of biomolecules. There are various types of biomolecules such as proteins, DNA, RNA, carbohydrates and metabolites. All the reactions in a biological system involve interactions ... -
Multimodal Duetting and Pair Formation in a Paleotropical False Leaf Katydid, Onomarchus uninotatus
The spectacular diversity in the pair-formation strategies among animal groups has attracted the attention of many over the years. The roots of this diversity lie in the diversity of challenges that males and females face ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ... -
Mutational analysis of Rpb4 and Rpb7 : Insights into their role in transcription and stress response of saccharomyces cerevisiae
The Yeast Saccharomyces cerevisiae as a Model System for Stress Response and Transcription The yeast Saccharomyces cerevisiae is an excellent model system to study the molecular basis of stress response. Apart from its ... -
Mutational sensitivity of CcdB mutants in their native operonic context
Determining the precise effects of thousands of point mutants on protein structure, stability, and activity is a challenging task. Chapter 1 introduces how next-generation sequencing technologies exploit phenotypic screens ... -
Mxr1p is a Global Regulator of Multiple Metabolic Pathways in the Methylotrophic Yeast Pichia Pastoris
(2018-03-01)The present study is aimed at examining the ability of Pichia pastoris to utilize acetate and amino acids as the sole sources of carbon. We demonstrate that the zinc finger transcription factor Mxr1p, which is a positive ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Mycobacterium Leprae RecA Intein : A LAGLIDADG Homing Endonuclease, Displays A Unique Mode Of DNA Binding And Catalysis Compared To A Canonical LAGLIDADG Homing Enzyme
(2010-09-30)Mobile genetic elements are DNA sequences that move around to different positions within one genome or between different genomes. Mobile DNA elements were initially considered as selfish DNA sequences parasitizing the ... -
Mycobacterium Smegmatis RecA And SSB : Structure-Function Relationships, Interaction With Cofactors And Accessory Proteins
(2011-04-06)Homologous genetic recombination, because of its fundamental roles in the maintenance of genome stability and evolution, is an essential cellular function common to all organisms. This process also plays important roles ... -
Mycobacterium smegmatis topoisomerase I : insights into site specific recognition and mechanism of action
Mycobacterium smegmatis TOPOISOMERASE I: INSIGHTS INTO SITE-SPECIFIC RECOGNITION AND MECHANISM OF ACTION The work embodied in this thesis is an attempt to understand the relaxation mechanism catalyzed by Mycobacterium ... -
Mycobacterium tuberculosis RecA intein, a novel LAGLIDADG homing endonuclease, displays dual target specificity in the presence of alternative cofactors
(Indian Institute of Science, 2005-05-10)Mobile inteins and introns are genetic elements capable of self-propagation by “homing” into host genes and occur in entire taxonomy: eubacteria, eukarya, archaea and viruses. The process of “homing” is promoted by an ... -
Network Heterogeneities, Intrinsic Plasticity and Decorrelation in the Dentate Gyrus
A central premise for research in neuroscience is to mechanistically decipher the physiological roles of the brain in effectuating learning and memory. The tripartite framework that is at the core of learning and memory ... -
Neural Correlates and Behavioral Underpinnings of Remote Memories during Systems Consolidation
Remote retrieval of declarative memories has been under investigation for a long time. After acquisition, long-term encoding of memories happens through crosstalk across multiple brain regions. Through systems consolidation, ...