Browsing Division of Biological Sciences by Title
Now showing items 701-720 of 1426
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Molecular Insights into Lymphoid Malignancy : Role of Transcription Factor BCL11B in T-cell Leukemia Genesis and Biochemical Characterization of DNA Binding Domain of RAG1
(2018-06-29)The lymphoid tissues consist of distinct cell subpopulations of B and T cell lineages and possess complex signaling pathways that are controlled by a myriad of molecular interactions. During the fine-tuned developmental ... -
Molecular insights into the genome organization and assembly of Sesbania Mosaic Virus
Abstract not available -
Molecular insights into the regulation of host unfolded protein response and angiogenesis during Mycobacterium tuberculosis pathogenesis
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), continues to co-evolve with the human population, rendering it one of the most significant global health threats among infectious diseases. The ... -
Molecular Insights into the Structure and Function of Pepper Vein Banding Virus Encoded Proteins and Endocytic Uptake Pathway of Virus-like Particles into Mammalian Cells
Viruses are major pathogenic agents that cause a variety of diseases in all living systems. Since their first isolation in 1892 by Dimitrii Ivanovsky, methods of their diagnosis and control, their life cycles, host - virus ... -
Molecular Interactions Between SARS-CoV-2 Viral and Human Cellular Factors: Implications for Viral Infection, Replication, and Disease
The COVID-19 pandemic was this century's most significant global public health crisis. The causative agent was SARS-CoV-2, an enveloped, single-stranded positive-sense virus. As an obligate intracellular pathogen, SARS-CoV-2 ... -
Molecular Mechanisms Underlying Phosphatidylinositol-Specific Phospholipase C Mediated Regulation Of Lipid Metabolism
(2016-03-04)Phosphoinositide-specific phospholipase C (PLC) is involved in Ca2+ mediated signalling events that lead to altered cellular status. PLC activation causes hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) and ... -
Molecular mimicry by an antiidiotypic monoclonal antibody to gonadotropin releasing hormone : Binding and signalling properties
This thesis deals with the establishment and characterization of monoclonal antibodies (mAbs) to gonadotropin-releasing hormone (GnRH) receptor, with particular emphasis on the investigations into the abilities of the mAbs ... -
Molecular modelling studies on wheat germ agglutinin-saccharide interactions
Thus, the present study provides many insights into the conformational dynamics of the saccharides in vacuum and in water. It shows that at room temperature, both in vacuum and in water, the sugar ring exhibits limited ... -
Molecular pathways governing maturation and decay of precursor piRNAs in Caenorhabditis elegans
Piwi-interacting RNAs (piRNAs) are an animal-specific class of germline-enriched small non-coding RNAs that play a crucial role in germline development and fertility in diverse organisms. In Caenorhabditis elegans (C. ... -
Molecular Phenotyping of Mutations in Guanylyi Cyclase C Associated with Congenital Diarrhea
(2018-02-28)Guanylyl cyclase C (GC-C) is a member of particulate guanylyl cyclases, discovered primarily as the target of a family of heat stable enterotoxins (ST), produced by enterotoxigenic Escherichia coli (ETEC). ST is acknowledged ... -
A molecular systems approach to unravel mechanisms and targets in antifolate-resistant bacteria and cancers
Antifolates such as trimethoprim (TMP) and methotrexate (MTX) widely used for treating bacterial infections and certain cancers respectively, inhibit dihydrofolate reductase (DHFR) in the folate pathway. However, the use ... -
Moonlighting Functions of the Rv0805 Phosphodiesterase from Mycobacterium Tuberculosis
(2018-04-18)All organisms must sense and respond to their environment in order to survive. The processes that allow a living cell to sense changes in its environment, and respond appropriately are collectively referred to as ‘signal ... -
Motifs in proteins: Disulfide constraints and their applications to protein engineering and peptide modelling
By carrying out a detailed data analysis of 175 PP motifs in proteins, sequence–structure relationships were identified for linking loops 1–5 residues long. Conformational families were recognized in 1-, 2-, 3-, and 4-residue ... -
Multi-faceted modular interactions in proteins
All living systems are composed of plethora of biomolecules. There are various types of biomolecules such as proteins, DNA, RNA, carbohydrates and metabolites. All the reactions in a biological system involve interactions ... -
Multimodal Duetting and Pair Formation in a Paleotropical False Leaf Katydid, Onomarchus uninotatus
The spectacular diversity in the pair-formation strategies among animal groups has attracted the attention of many over the years. The roots of this diversity lie in the diversity of challenges that males and females face ... -
Multiple routes to tackling drug-resistant tuberculosis: Systems modeling to unravel resistance mechanisms, drug combinations, and novel host-based biomarkers
Tuberculosis (TB) has been a major public health problem. The successful treatment of TB requires long-term (6-months) multi-drug chemotherapy, but poor patient compliance and non-adherence lead to the evolution of ... -
Mutational analysis of Rpb4 and Rpb7 : Insights into their role in transcription and stress response of saccharomyces cerevisiae
The Yeast Saccharomyces cerevisiae as a Model System for Stress Response and Transcription The yeast Saccharomyces cerevisiae is an excellent model system to study the molecular basis of stress response. Apart from its ...