Browsing Division of Biological Sciences by Title
Now showing items 661-680 of 1026
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Role of autophagy in reducing peripheral neuropathy and diabetic peripheral neuropathy
Peripheral neuropathy occurs when there is damage to the central or peripheral nervous system due to injury, disease, diabetes, or drug use. Endoplasmic reticulum (ER) stress is a distinct feature observed in neuropathic ... -
Role of calcium sensors in differential alignment of synaptic nanomachinery during neurotransmission
Some of the brain's most remarkable feats such as learning and memory, are thought to emerge from elementary properties of chemical synapses. The distinctive feature of these synapses is that the action potential in the ... -
Role of CG9650 in Neuronal Development And Function of Drosophila Melanogaster
(2017-10-05)The nervous system is the most complex system in an organism. Functioning of the nervous system requires proper formation of neural cells, as well as accurate connectivity and signaling among them. While the major events ... -
Role of Chemokine Receptor, CXCR4 Mediated Signaling in Cellular Senescence
(2017-10-05)Cellular senescence has been proposed to be equivalent to organismal aging and is one of the outcomes of the cell fate decision process in response to DNA damage that occurs in cells. When a cell encounters DNA damage, the ... -
Role of conserved features of initiator tRNA and ribosome heterogeneity in translation initiation in Escherichia coli
Translation is one of the fundamental and core cellular processes catalysed by a ribonucleoprotein complex called ribosome. The process involves four major steps: initiation, elongation, termination and recycling. Initiation ... -
The Role of Cytoskeletal Morphology in the Nanoorganization of Synapse
(2018-01-10)Synapse is the fundamental unit of synaptic transmission. Learning, memory and neurodegenerative diseases of the brain are attributed to the maintenance and alteration in synaptic connections. The efficiency for synaptic ... -
Role of DNA Methylation in Glioblastoma Development
(2018-04-11)Glioblastoma (GBM) is the most common and malignant of the glial tumors. These tumors may develop from lower-grade astrocytomas (diffuse astrocytoma; grade II or anaplastic astrocytoma; grade III) through a progressive ... -
The Role of DNA Structural Features of Eukaryotic Promoter Sequences in Transcription Regulation
(2018-09-04)Understanding the molecular structure of DNA was considered as greatest achievement in modern biology. It helped in understanding fundamental cellular processes such as replication of DNA, nature of the ... -
Role of Escherichia coli UvrD helicase in resolving G-quadruplex DNA structures
G-quadruplex (G4) secondary structures have been implicated in various biological processes, including gene expression, DNA replication and telomere maintenance. However, unresolved G4 structures impede replication ... -
Role of Glycosylation and Oligomerization on the Stability of Soybean Agglutinin
Carbohydrates are vital to life. In their naive form, they serve as a primary energy source for supporting life. However, in most cases carbohydrates do not exist as simple sugars in nature. Instead they occur as more ... -
Role of Grp 75 Chaperone Folding Machinery in the Maintenance of Mitochondrial Protien Quality Control
(2018-04-03)My research focuses on understanding the importance of human mitochondrial Hsp70 (Grp75) chaperone machinery for the maintenance of protein quality control inside the mitochondrial matrix. The investigations carried out ... -
Role of Hydrogen Sulfide Gas in Modulating HIV-1 Latency and Reactivation
Human Immunodeficiency Virus 1 (HIV-1) remains a global public health threat, claiming 690 thousand people’s lives in 2020 and causing 1.5 million new infections. The advent of combinatorial antiretroviral therapy (ART) ... -
Role Of Idiotypic Anti-Idiotypic Network In The Sustenance Of Immunological Memory
(2009-05-25)Living amidst a milieu of pathogenic organisms, vertebrates are in constant threat of contracting one or the other disease. As a mechanism of protection against such ‘invasions’, the vertebrate immune system has evolved ... -
The Role of Initiation Factor 3 : Insights from E. Coli, Mitochondria and Mycoplasma
(2018-01-07)The process of translation initiation is the most highly regulated step of protein synthesis. In bacteria, three initiation factors (IF1, IF2 and IF3) play crucial roles during initiation. IF3 acts as an anti-association ... -
Role Of Insulin-Like Growth Factors Binding Protien 2 (IGFBP2) In Breast Cancer
(2016-04-27)Insulin-like growth factor binding proteins (IGFBPs) modulate the bioavailability of IGFs in circulation. IGFBPs 1-6 bind IGFs with high affinity and can either potentiate or inhibit IGF signaling in a context dependent ... -
Role of Lactate and TREK1 Channels in Neuroprotection during Cerebral Ischemia – in Vitro Study in Rat Hippocampus
(2017-12-16)Cerebral ischemia is a highly debilitating condition where shortage of oxygen and glucose leads to profuse cell death. Insufficient blood supply to the brain leads to cerebral ischemia and increase in extracellular lactate ... -
Role of Lysyl oxidase in TGF-beta-induced Fibroblast Activation and Cancer-Associated Fibroblast-mediated Breast Cancer Progression
Cancer-associated Fibroblasts (CAFs) are a dominant cell type of the breast cancer microenvironment and are proposed to be involved in metastatic progression. TGF-β has been reported to influence fibroblast to myofibroblast ...