Browsing Division of Biological Sciences by Title
Now showing items 54-73 of 1026
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CcdB : Stability, folding and application to design novel antibacterials
The primary amino acid sequence typically dictates the ultimate conformation of the protein. Mutations in the sequence demonstrate neutral, positive or negative effects on the structure-function relationship of the protein. ... -
Cell Surface Of Mycobacterium Smegmatis At The Stationary Phase : Regulation Of Gene Expression
(2009-05-21)Tuberculosis remains one of the oldest diseases known to mankind but still persists as a very major risk. Discovery of several antimycobacterials was marked by a steady decline in the active cases of pulmonary tuberculosis. ... -
Cell Survival Strategies : Role Of Gyrase Modulatory Proteins
(2010-07-21)A steady state level of negative supercoiling is essential for chromosome condensation, initiation of replication and subsequent elongation step. DNA gyrase, found in every eubacteria, serves the essential housekeeping ... -
Cellular and Molecular Features of the Response of Mycobacterium smegmatis to Rifampicin and Moxifloxacin Upon Prolonged Exposure
Bacterial persisters are a subpopulation of bacteria that can tolerate lethal concentrations of antibiotics. These are phenotypic variants that can give rise to drug‐susceptible population upon withdrawal of the antibiotic. ... -
Characterisation Of DNA Llgase And Pairing Activities From A Partially Purified Fraction From Rat Testis
(Indian Institute of Science, 2005-04-06)Homologous genetic recombination is a central feature of meiosis in most sexually dividing organism. It leads to the establishment of new linkage relationships between genes and is crucial for the successful completion of ... -
Characterisation of Monoclonal Antibodies and Small Molecule Inhibitors as Hepatitis C Virus Entry Inhibitors
(2017-12-15)Hepatitis C virus (HCV) represents a global health threat. HCV is a blood-borne positive-strand RNA virus belonging to the Flaviviridae family that infects ~160 million people worldwide. About 70% of infected individuals ... -
Characterization of an In Vitro Transcription System for Peste Des Petits Ruminants Virus and Functional Characterization of RNA Triphosphatase Activity of RNA Dependent RNA Polymerase Protein L
(2018-03-03)Peste des petits ruminants virus (PPRV) belongs to the family paramyxoviridae which comprises non segmented negative sense RNA viruses including measles and rinderpest virus. PPRV is the causative agent of peste des petits ... -
Characterization Of Down Regulated Genes In Astrocytoma
(2011-07-27)Gliomas are the most common primary brain tumors and include astrocytomas, oligodendrogliomas and oligoastrocytomas. Astrocytomas have a high frequency of occurrence as compared to the other gliomas and several studies ... -
Characterization of Host Protein Interactions with HCV RNA : Implications in Viral Translation, Replication and Design of Antivirals
(2018-05-09)HCV genome is a positive sense single-stranded RNA containing a single open reading frame (ORF) flanked by untranslated regions (UTRs), 5’UTR and 3’UTR.Initiation of HCV RNA translation is mediated by internal ribosome ... -
Characterization Of HP1369-HP1370 From Helicobacter Pylori : A Novel ε Type N6 –Adenine Methyltransferase
(2013-07-18)Helicobacter pylori is one of the most genetically diverse bacterial species that successfully colonizes at least 50% of the world population. It has been associated with humans for thousands of years and most probably ... -
Characterization Of Human Mammary Stem Cells Grown As Mammospheres
(2011-01-11)Adult stem cells are a small population present within several tissues of an individual, possessing two unique properties: one, the ability to differentiate to give rise to all the cell types of the tissue, and second, the ... -
Characterization of mouse Apolipoprotein L9 and investigation of its cellular functions
This thesis is divided into 3 chapters. Chapter 1, titled General Introduction, is a chapter that familiarizes the reader with the general subject matter of the thesis so that the content of Chapters 2 and 3 can ... -
Characterization of Neuroprotective Reactive Astrocytes in the Aging Mammalian Brain
The brain manifests cognitive deficits in aging and becomes more vulnerable to neurodegeneration. Astrocytes play several critical roles in the brain, including synapse formation, maturation, elimination, and synaptic ... -
Characterization Of Structural And Non-structural Proteins Of Positive Sense, Single-stranded RNA Plant Viruses
(2015-07-08)In the present thesis, two positive sense single-stranded RNA viruses have been used as models to understand the structure and function of viral-encoded proteins. One of them, Pepper Vein Banding Virus (PVBV; genus Potyvirus; ... -
Characterization of the Cis and Trans Acting Factors that Influence p53 IRES Function
(2018-03-07)p53 is a nodal tumor suppressor protein that acts as a major defense against cancers. Approximately 50% of human tumours have mutations in p53 gene. Among its myriad features, the most distinctive is the ability to elicit ... -
Characterization of the transsulfuration enzyme Cystathionine beta-synthase as a novel regulatory node in the sulfur metabolism of Mycobacterium tuberculosis
Methionine and cysteine metabolisms are important for the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). The transsulfuration pathway converts methionine to cysteine and represents an important link between ... -
Characterization of Thymocyte Subpopulations and Mechanistic Insights during Various Modes of Thymic Atrophy
T lymphocytes along with B lymphocytes constitute the adaptive immune system, which is critical for host defence. The progenitors of T cells arise in the bone marrow and the sequential development of T cells occurs in the ...