Browsing Division of Biological Sciences by Title
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Integration of sequences, structures, dynamics to study functional divergence in homologous proteins and their assemblies
Functions of proteins are governed by their sequences, structures, dynamics and assembly. Modulation of these factors during evolution renders functional divergence in related proteins that have originated from the common ... -
An integrative analysis of Cell Adhesion Molecules (CAMs) in Glioma: The Essential role of PTGFRN and ASTN1 in Glioma and Glioma Stem-like Cells
The central nervous system tissue contains neural stem cells which differentiate and give rise to the neurons and glial cells. The glial cells maintain neurons by providing nutrients, physical support and protection. Unlike ... -
Integrative modeling of NS3 helicase function with molecular kinetics, molecular simulations and machine learning
The viral NS3 helicase is a crucial enzyme involved in the RNA replication of positive strand ssRNA viruses of the Flaviviridae family. The NS3 is an active motor that binds RNA and couples ATP hydrolysis to the mechanical ... -
Integrative multiscale modeling and simulations of biomolecules with experimentally testable predictions
This thesis delves into four separate research works related to Integrative multiscale modeling and simulations of biomolecules. The first work deals with the puzzling case of the Pleckstrin Homology Domain (PHD), which ... -
Interaction Of Chaperone SecB With Protein Substrates: A Biophysical Study
(Indian Institute of Science, 2006-10-17)In the cell, as in in vitro, the final conformation of a protein is determined by it's amino acid sequence (1). Some isolated proteins can be denatured and refolded in vitro in absence of extrinsic factors. However, in ... -
Interaction of hnRNPK with RNA and characterization of its phase separation behavior
Heterogenous ribonucleoproteins (hnRNPs) are a class of proteins initially discovered to protect the nascent transcripts before they develop into primary mRNAs. They are involved in almost all the stages of mRNA metabolism, ... -
Interaction of the TCP4 protein with other transcription factors and its effect on Arabidopsis shoot apex
The TEOSINTE BRANCHED1, CYCLOIDEA, PROLIFERATING CELL FACTORs (TCP) class of proteins are plant-specific transcription factors with a non-canonical basic helix-loop-helix (bHLH) domain involved in both DNA-binding and ... -
Interactions between host cellular factors and Rotaviral viroplasmic non-structural proteins NSP5, NSP2 and their influence on virus replication
Overall, the present study demonstrates the dynamic nature of rotavirus viroplasm and how it manipulates the intracellular environment by intracellular relocalization of host proteins and their sequestration in viroplasms ... -
Interrelationship between heme and mitochondrial protein synthesis in the mold Neurospora Crassa
Abstract not available -
Intracellular Calcium Dynamics In Dendrites Of Hippocampal Neurons Rendered Epileptic And In Processes Of Astrocytes Following Glutamate Pretreatment
(2009-04-03)The fundamental attribute of neurons is their cellular electrical excitability, which is based on the expression of a plethora of ligand- and voltage-gated membrane channels that give rise to prominent membrane currents ... -
Intragenic pausing and regulation of cyp 2B1/B2 gene expression in rob liver-role of heme
Abstract not available -
Intrasexual competition in females of a socially polygynous lizard, Psammophilus dorsalis
Competition between individuals of the same sex, intrasexual competition, has received much attention in males, mainly because such competition, which is primarily for mates (i.e. sexual selection), often selects for ... -
Intrinsic Noise in Collective Dynamics
Animal groups exhibit many emergent properties that are a consequence of local interactions. Linking individual-level behaviour to group-level dynamics has been a question of fundamental interest from both biological and ... -
Intrinsic Versus Induced Variations In DNA Structure
(2011-07-18)The binding of different proteins involved in processes such as transcription, replication and chromatin compaction to regions of the genome is regulated by the structure of DNA. Thus, DNA structure acts as the crucial ... -
Invertase in a thermophilic fungus, thermomyces lanuginosus: its unusual behaviour And regulation
(Indian Institute of Science, 2005-04-25)The understanding of the phenomenon of thermophily requires investigations of both thermophilic prokaryotes and eukaryotes. In the eukaryotes, thermophily is exhibited only by a few species of fungi which can grow up to ... -
Investigating DJ-1 homologs in maintaining genome integrity through glycation repair of macromolecules: Implications in regulating mitochondrial health
The current thesis work focuses on DJ-1 superfamily proteins and their role in protection against toxic glycating carbonyls such as Methylglyoxal (MG) and Glyoxal (GO). Our study reveals that yeast DJ-1 homologs (Hsp31 ... -
Investigating DNA structural basis for fragility during chromosomal translocations associated with human B-cell lymphomas
Genome integrity is essential for normal cellular functions. Erroneous repair of DNA double-strand breaks (DSBs) could lead to chromosomal rearrangements, including chromosomal translocations that may result in altered ...