Browsing Division of Biological Sciences by Title
Now showing items 368-387 of 1026
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In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia
Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ... -
Infection of Human Cell Lines by Japanese Encephalitis Virus : Increased Expression and Release of HLA-E, a Non-classical HLA Molecule
(2018-04-24)Japanese encephalitis virus (JEV) causes viral encephalitis in new born and young adults that is prevalent in different parts of India and other parts of South East Asia with an estimated 6000 deaths per year. JEV is a ... -
Influence Of FtsH Protease On The Medial FtsZ Ring In Escherichia Coli
(2013-07-17)FtsH is an essential AAA family Zn++ metalloprotease of Escherichia coli, possessing ATPase-dependent chaperon activity and ATP-dependent protease activity. Heat shock transcription factor Sigma32, LpxC, SecY, and bacteriophage ... -
The Influence of Glycerol and Specific Genes on the Asymmetric Cell Division in Mycobacteria
The Influence of Glycerol and Specific Genes on the Asymmetric Cell Division in Mycobacteria Submitted by Atul Pradhan (S.R. No. 03-04-00-10-11-14-1-11678) Background Information: Mycobacteria maintain heterogeneity in ... -
The influence of landscape composition on butterfly populations: A behavioural ecological approach
Overall, taking behavioural ecological and trait-based approaches, my study suggests that the distribution of a species and patterns in its population densities in a landscape are affected by diverse ecological variables, ... -
Influence of Tgf-B on Mechanobiology of Human Breast Cancer Cells
Breast cancers are characterized by extensive modifications to mechanical properties of the tissue via increased ECM production and vascularization. TGF-B is a multi-functional cytokine that is implicated in cancer invasion ... -
Influence of the substrate specificity of Mycobacterium tuberculosis ClpX on the transcriptional profile
Cellular homeostasis in bacteria is maintained by diverse molecular machines. These include several one-component systems (OCS), two- component systems (TCS), chaperone proteins, proteases, proteolytic complexes and ... -
Initiation of protein synthesis : Role of the three consecutive GC base pairs in the anticodon stem of initiator tRNAs
The presence of the three consecutive GC base pairs in the anticodon stems of the initiator tRNAs (3GC base pairs) are a highly conserved and a vital feature of the initiator tRNAs in all the domains of life. How this ... -
Insight into luteolytic effects of repeated administration of LH in pregnant rats: Analysis of cAMP/PKA pathway during LH-induced luteolysis
The Corpus luteum (CL) is a dynamic endocrine structure that develops in the ovary from the remnants of the ovulated follicle and plays a critical role in the control of estrous/menstrual cycle as well as in establishment ... -
Insights into an Evolutionary Radiation : Causes And Consequences of Diversification in the Western Ghats Bush Frogs
(2017-10-26)One of the biggest attractions of the tropics is its stunning diversity; the origin and determinants of this diversity are amongst the most important questions in evolution and biogeography. There are two ways of looking ... -
Insights Into Cytostatic Mechanisms Regulated By Receptor Guanylyl Cyclase C
(2016-11-16)All cells are equipped to sense changes in their environment and make adaptive responses according to the stimuli. Signal recognition usually occurs at the cell membrane (with the exception of steroid signalling) where the ... -
Insights into Differentiation of Mouse Pluripotent Stem Cells to Neural Lineage
(2017-12-10)Pluripotent stem cells (PSCs: ESCs and iPSCs) provide an excellent model system for studying neural development and function. These cells also serve as a reliable source of cell replacement for the treatment of various ... -
Insights into Differentiation of Pluripotent Stem Cells to Cardiac Progenitors and Cardiomyocytes
The mammalian heart is the first organ formed during development. It forms the crux of the circulatory system of the body and pumps blood (and therefore, nutrients) to all parts of the body. The continuous functioning of ... -
Insights into life-cycle stage transition of Trichomonas vaginalis and advancement in its diagnosis
Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ... -
Insights Into Molecular Regulation Of Cardiomyocyte Differentiation Of Mouse Pluripotent Stem Cells
(2015-08-03)Pluripotent stem cells (PSCs) are specialized cells, which have remarkable ability to maintain in an undifferentiated state and are capable of undergoing differentiation to three germ-layer lineage cell types, under ... -
Insights into mRNA recruitment by eukaryotic initiation factor 4 during translation in Saccharomyces cerevisiae
Ribosomes are responsible for synthesizing proteins in the cells by using mRNA as the template. However, the ribosomes cannot perform this function without the help of other protein factors. Different factors are required ... -
Insights into Occurrence and Divergence of Intrinsic Terminators and Studies on Rho-Dependent Termination in Mycobacterium Tuberculosis
(2018-04-11)Two mechanisms, intrinsic and factor-dependent, have evolved for accomplishing the termination of transcription in eubacteria. In this thesis, the first chapter is an introduction to the topic that presents what is known ... -
Insights Into Oxidative Folding Of Retinol Binding Protein In The Endoplasmic Reticulum : A Study In Isolated Microsomes
(2009-04-30)The central role played by the Endoplasmic Reticulum (ER) in the correct folding and assembly of secretary and membrane proteins cannot be overstated. As the first compartment in the secretary pathway, it is responsible ... -
Insights into the conformational stability & pharmacology of peptides through side chain and backbone modification
The first part of the work presented in the thesis deals with CH-pi interaction, which is a lesser-known non-covalent interaction in proteins. We identified several CH-pi donor-acceptor pairs involving amino acids side ...