Browsing Division of Biological Sciences by Title
Now showing items 234-253 of 1426
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Development of quantitative RNA sequencing methods to understand RNA variant diversity.
The advent of next-generation sequencing (NGS) has accelerated biological research by providing the opportunity to connect genome level sequence information to function. One key application of NGS has been analysis of gene ... -
Developmental And Functional Regulation Of DNA Topoisomerase II in Postnatal Rat Testis
(Indian Institute of Science, 2005-11-23)Characterization of the polyoma virus chromosome as a circular, double-stranded, supercoiled DNA (Weil and Vinograd, 1963; Vinograd et al.,-1965) made it apparent that the DNA enzymatic machinery faces a formidable problem ... -
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
(2018-05-23)Muscle contraction is a highly fine-tuned process that requires the precise and timely construction of large protein sub-assemblies to form sarcomeres, the individual contractile units. Mutations in many of the genes ... -
Developmental Basis and Diversity of Polar Growth Patterns in Leaves
(2018-03-06)Growth polarity in leaves – a final discussion Insights into the growth processes of leaf lamina have come from studies on several species including Arabidopsis, Antirrhinum, tobacco and maize. A feature common to the ... -
Diaminopropionate Ammonia Lyase : Characterization, Unfolding And Mechanism Of Inhibition By Aminooxy Compounds
(2009-03-13)Diaminopropionate ammonia lyase (DAPAL) which belongs to the class of PLP enzymes is reported only from prokaryotes. It is involved in the removal of two amino groups from its substrate, diaminopropionate, to form ammonia ... -
Differential DNA methylation patterns in primary and recurrent glioblastomas : Protumorigenic roles of Tumor Endothelial Marker 8 (TEM8) and ASAP1 genes
Glioblastomas (GBMs) are clinically aggressive malignant brain tumors in adults with a median survival of 14 months on diagnosis. Therapeutic interventions such as debulking surgeries, chemotherapy, and ionizing radiation, ... -
Differential Regulation of Calcium Dependent Phase Separation and Modular Assembly of Sap97/Hdlg Enriched Molecular Complexes
Recent studies over a few decades have changed the perspective of the molecular architecture of functional zones within synapses and other cell junctions. Observations in the last decade confirm Post Synaptic Density as ... -
Differential Regulation Of tRNA1 Gly Genes In Bombyx Mori
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Dispersal Patterns and Processes in Littorinid Snails along the Indian Coastline
Dispersal has important ecological and evolutionary consequences for a species. Marine dispersal is unique because of facilitation by ocean currents, where oceanography interacts with species traits and environmental ... -
Dissecting the C-DI-GMP Signaling Pathways : Tools and Tales
(2018-02-27)Evaluating aerodynamic noise from aircraft engines is a design stage process, so that it conform to regulations at airports. Aerodynamic noise is also a principal source of structural vibration and internal noise in ... -
Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells
In animal cells, the duplicated genetic material is aligned on a microtubule-based structure known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, and the sister chromatids get ... -
Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster
Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ... -
Dissecting the Role of Calcium Binding Proteins in Muscle using Drosophila Indirect Flight Muscles as the Model System
Muscle development and function are highly synchronized processes that involve simultaneous action of several transcription factors, signalling cascades, kinases and phosphatases, ion channels, structural proteins and ... -
Distinct Drivers of Type 2 Diabetes: A Systems Modeling Approach to Molecular, Genetic, and Metagenomic Insights
Type 2 Diabetes (T2D) is a complex and heterogeneous disease characterized by hyperglycemia, insulin resistance, and impaired insulin secretion. While often interrelated, hyperglycemia and insulin resistance represent ... -
Distinct extracellular signatures of active-dendritic chemical and electrical synapses differentially contribute to ripple-frequency oscillations
Extracellular field potentials across brain regions exhibit distinct signatures that depend on several region-specific attributes, including spatiotemporal patterns of afferent inputs, anatomical and physiological properties ... -
Distribution, activity budget and feeding ecology of Himalayan gray langur (Semnopithecus ajax) in Kashmir Himalaya
Colobines are group of primates known to inhabit harsh environments. These habitats pose different challenges which they have coped up physiologically and behaviourally. Primates in such environments are subjected to ...