Browsing Division of Biological Sciences by Title
Now showing items 201-220 of 1026
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Effect of Ultrasound on Neuronal Network Communication
(2018-05-22)Low intensity and low frequency ultrasound has been shown to modulate ion channel currents, membrane capacitive currents, and as a result, neuronal activity. Ultrasound has been used as a non-invasive way to modulate ... -
Effects of Cyclic Permutation, Glycan Removal and Aspartate Mutagenesis on Conformation of HIV-1 Envelope
It has been decades since Human Immunodeficiency Virus-1 (HIV-1) was discovered. The virus has created havoc worldwide. According to the UNAIDS 2014 Gap report, 35million people worldwide are infected with HIV-1 and yet ... -
Effects of Steroid Hormones on Insulin Sensitivity and Lipogenesis: An Insight into the Involvement of the Wnt Signaling Pathway
The shift in maternal energy metabolism characteristic of pregnancy is thought to be driven by various hormonal changes, especially of ovarian and placental steroids. In this context, the effect of estradiol (E2), progesterone ... -
Elucidating Deregulated Novel Pathways in Glioma through Genetic and Epigenetic Approaches
Malignancy of glial cells is termed as glioma. Gliomas comprise of thirty percent of all tumors of the central nervous system (CNS) and eighty percent of malignant brain tumors (Goodenberger and Jenkins, 2012). Astrocytoma, ... -
Elucidating the mechanism of interaction of Salmonella with plants
Salmonella, is an established pathogen of members of the kingdom Animalia. Its principal species S. enterica serovars Typhi, Paratyphi and Typhimurium can cause various diseases ranging from typhoid fever to gastroenteritis ... -
Elucidating the role of carbon metabolism genes chiA and yjiY in Salmonella pathogenesis.
Salmonella is a foodborne pathogen that causes debilitating enteric diseases in a wide range of hosts. While Salmonella Typhimurium causes self-limiting gastroenteritis in human beings, Salmonella Typhi causes typhoid fever ... -
Elucidating the Role of Cyclic GMP in Diarrhoea and Intestinal Inflammation
Cyclic guanosine 3’,5’-monophosphate (cGMP) performs a wide range of functions in various cell types and tissues. The cellular levels of cGMP are maintained by the enzymatic conversion of guanosine 5’-triphosphate (GTP) ... -
Elucidating the Role of miR-617 in Oral Squamous Cell Carcinoma Pathogenesis
Oral Squamous Cell Carcinoma (OSCC) or oral cancer is the malignancy of the epithelial lining of the oral cavity. It is the leading cause of cancer-related mortality in Indian males and despite technological advancements, ... -
Elucidating the Role of MsRbpA in Rifampicin Tolerance and Transcription Regulation of Mycobacterium Smegmatis
(2018-04-12)RNA polymerase binding protein A (RbpA) was first discovered as a RNA polymerase binding protein from Streptomyces. coelicolor. It was shown to cause rifampicin tolerance to RNA polymerase in vitro and leads to basal level ... -
Elucidating the role of SNARE Syntaxin 1A in regulating lysosome and melanosome function
SNAREs are transmembrane proteins that localize to specific membranes and facilitate the process of membrane/vesicle fusion. SNAREs mediate the fusion by binding with their respective cognate SNAREs. SNAREs mediate the ... -
Elucidating the Roles of Lon Protease and its Substrate, MarA, in Response to salicylate and other Compounds in Escherichia coli
(2017-11-28)Cytosolic protein degradation is crucial for cellular homeostasis as it orchestrates protein turnover by destruction of misfolded, unstable and abnormal proteins. This process has two main stages: (i) an ATP-dependent stage ... -
Elucidation of 17β-Estradiol (E2) Role in the Regulation of Corpus Luteum Function in Mammals : Analysis of IGFBP5 Expression during Ea-mediated Actions
(2017-12-12)Corpus luteum is a transient endocrine structure formed from the ruptured ovarian follicle. Its main function is to secrete P4, a pro-gestational hormone, essential for establishment and maintenance of pregnancy in mammals. ... -
Elucidation Of Differential Role Of A Subunit Of RNA Polymerase II, Rpb4 In General And Stress Responsive Transcription In Saccharomyces Cerevisiae
(2010-09-14)RNA polymerase II (Pol II) is the enzyme responsible for the synthesis of all mRNAs in eukaryotic cells. As the central component of the eukaryotic transcription machinery, Pol II is the final target of regulatory pathways. ... -
The Elucidation of the Mechanism of Meiotic Chromosome Synapsis in Saccharomyces Cerevisiae : Insights into the Function of Synaptonemal Complex, Hop1 and Red1, Proteins and the Significance of DNA Quadruplex Structures
(2017-12-03)Meiosis is a specialized type of cell division where two rounds of chromosome segregation follow a single round of DNA duplication resulting in the formation of four haploid daughter cells. Once the DNA replication is ... -
Elucidation of the Role of Nse1, a RING Domain Containing Component of Smc5/6 complex, in Maintenance of Chromosome Stability in Saccharomyces cerevisiae
(2018-05-21)Structural Maintenance of Chromosomes (SMC) proteins are a highly conserved class of proteins required for the maintenance of genome stability and regulate nearly all aspects of chromosome biology. Eukaryotes, such as the ... -
Embryonic Expression of Cytokines: Functional Role of Il-1β During Blastocyst Hatching
The detailed investigation on the embryo-endometrial cytokine expression, in both mouse and hamster, was carried out during the peri-hatching development and it is described in chapter 2. We hypothesize that, for a ... -
Emergence and Homeostasis of Functional Maps in Hippocampal Neurons
(2017-11-23)Systematic investigations through several experimental techniques have revealed that hippocampal pyramidal neurons express voltage gated ion channels (VGICs) with well-defined gradients along their dendritic arbor. These ... -
Endotoxin Peptide/Protein Interactions: Thermodynamic And Kinetic Analysis
(Indian Institute of Science, 2006-05-15)Endotoxin or Lipopolysaccharide (LPS) is the invariant structural component of gram negative bacterial outer membranes and is the chief causative factor of Sepsis or endotoxic shock. Sepsis is a syndrome that has very high ... -
Energetics Of Protein-Carbohydrate Recognition
(Indian Institute of Science, 2006-04-28)The work embodied in this thesis pertains to an attempt to understand better, the molecular basis of protein-carbohydrate recognition. For this purpose a systematic study was undertaken, not only of the energetics of ... -
Engineering Reverse Turns: Implications in Conformation, Stability and Bioactivity of Peptides and Proteins
The work presented in this thesis provides an overview of the potential role of N-methylation in inducing reverse turns. Backbone N-methylation is one of the common modifications designed by nature and exploited by humans ...