Browsing Division of Biological Sciences by Title
Now showing items 180-199 of 1514
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Crystal structure of low humidity monoclinic lysozyme at 1.75 Resolution
It has been demonstrated earlier in this laboratory that many protein crystals, but not all, undergo reversible structural transformations, as evidenced by abrupt changes in unit cell dimensions, diffraction pattern, and ... -
Crystallization and Preliminary Structural Studies on Mycobacterium tuberculosis RuvX
The deadly pathogen Mycobacterium tuberculosis has been characterized for its virulence in immense detail. Regardless of this, the capability of M. tuberculosis to combat extreme stress conditions inside the host cell for ... -
Crystallographic and analytical ultracentrifugation studies of the E. coli acetohydroxy acid synthase I enzyme
This thesis ellucidates the mechanism of activation and regulation of AHAS I enzyme from Escherichia coli that was characterised using crystallographic and sedimentation velocity analytical ultracentrifugation studies. AHAS ... -
Crystallographic and modelling studies on a mannose-specific lectin from garlic bulbs
Lectins are multivalent carbohydrate-binding proteins which exert their biological effects through their ability to specifically bind different sugars. They occur in plants, animals, bacteria, and viruses. They exhibit ... -
Cyclic AMP In Mycobacteria Adenylyl Cyclases And Cyclic AMP Receptor Proteins
(2013-01-28)The discovery of cyclic AMP (cAMP), nearly 50 years ago by Sutherland radically altered the appreciation of metabolic regulation. Since then the presence of cAMP and its tremendous physiological impact has been demonstrated ... -
Cyclic AMP-Regulated Protein Lysine Acetylation In Mycobacteria
(2015-07-17)Tuberculosis continues to be one of the major causes of morbidity and mortality worldwide. Several mycobacterial species such as M. tuberculosis and M. africanum are responsible for causing this disease in humans. Reports ... -
Cyclic nucleotide-binding proteins in mycobacteria
Mycobacterium tuberculosis, one of the leading causes of death worldwide even today, employs the second messenger cAMP extensively for its pathogenicity and persistence. Intracellular and extracellular levels of cAMP in ... -
Cyclic peptide disulfides as conformational models; synthesis and spectroscopic studies
The study of small peptides has been motivated both by the high biological activity manifested by many peptides and their potential use as model systems for understanding polypeptide and protein structure. The development ... -
Cytological phenomena succeeding sporulation in saccharmyces carlsbergensis
CONCLUSIONS SEPARATION OF YEAST VEGETATIVE AND YEAST NUCLEI – A COMPARISON The Nucleus in the Living Cell as the Standard. The investigations embodied in this thesis were planned to elucidate the resemblances in the structure ... -
Cytosolic Lysophosphatidic Acid Acyltransferase : Implications in Lipid Biosynthesis in Yeast, Plants and Human
(2018-02-11)Cytosolic LPA acyltransferase in yeast An isooctane tolerant strain of S. cerevisiae KK-12 was reported to have increased saturated fatty acid content (Miura et. al., 2000). Amongst the various genes upregulated on isooctane ... -
Cytotoxic T lymphocyte Responses Against Japanese Encephalitis Virus In Mice: Specificity And Immunotherapeutic Value
(Indian Institute of Science, 2005-10-07)Cytotoxic T Lymphocytes (CTL) are known to play an important role in clearing infectious virus from infected hosts in a variety of viral infections. Depending on the type of virus and mode of virus entry both class I and ... -
Deciphering canonical and non-canonical role of splicing factor Prp16 in pathogenic yeast C. neoformans
RNA splicing is a ubiquitous process during eukaryotic gene expression, where non-coding introns are removed from primary transcripts to form functional mRNA. This vital process is carried out by the spliceosome, a large ... -
Deciphering Functions & Interactions of Fission Yeast Splicing Factor SpSlu7 Relevant to Constitutive & Alternative Splicing
The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ... -
Deciphering Hypoxic Adaptations in Cutibacterium acnes using Multi-omics Profiling and Systems Modelling
The opportunistic skin anaerobe Cutibacterium acnes (C. acnes) contributes to skin homeostasis with its antioxidant and immunomodulatory activities. C. acnes (formerly known as Propionibacterium acnes) is an aerotolerant, ... -
Deciphering Structure-Function Relationships in a Two-Subunit-Type GMP Synthetase by Solution NMR Spectroscopy
(2018-04-24)The guanosine monophosphate synthetase (GMPS) is a class I glutamine amidotransferase, involved in the de-novo purine nucleotide biosynthesis. The enzyme catalyzes the biochemical transformation of xantosine (XMP) into ... -
Deciphering the biochemical and biophysical properties of the Holliday junction resolvases RuvC and RuvX from Mycobacterium smegmatis
Homologous recombination (HR) is a ubiquitous cellular process that occurs in all three domains of life as well as in DNA and RNA viruses. In eukaryotes, HR is critically important for homology-directed DNA repair (HDDR) ... -
Deciphering the evolutionary ecology of snake venoms and its impact on snakebite therapy in India
Venom, being an adaptive trait, has propelled the expansion of snake lineages across diverse habitats, such as the biogeographically distinct Indian landscapes. Natural selection optimises the potency, composition and ... -
Deciphering the evolutionary significance of maintaining cryptic genetic systems by bacteria
Cryptic genes are phenotypically silent DNA sequences with the potential to code for a function, but remain inactive during the normal life span of the organism. However they can be activated by a single mutational event ... -
Deciphering the function of sesaminol as an anti-obesity and anti-MAFLD molecule
Obesity and its associated metabolic diseases, including type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction-associated liver disease (MAFLD), pose significant global health challenges. ... -
Deciphering the genetic regulators of cuticle barrier function and longevity in Caenorhabditis elegans
Ever since Sydney Brenner introduced Caenorhabditis elegans in the early 60s as a model system, this worm has contributed to many ground-breaking discoveries in science. It has served as an excellent model to study animal ...