Browsing Division of Biological Sciences by Title
Now showing items 154-173 of 1026
-
Development of patient-derived tumor models toward understanding disease biology and drug screening
Cancer is a complex disease of uncontrolled cell proliferation, which cripples the normal functioning of tissues. According to GLOBOCAN 2020, an estimated 19.3 million new cancer cases and around 10 million cancer deaths ... -
Development of quantitative RNA sequencing methods to understand RNA variant diversity.
The advent of next-generation sequencing (NGS) has accelerated biological research by providing the opportunity to connect genome level sequence information to function. One key application of NGS has been analysis of gene ... -
Developmental And Functional Regulation Of DNA Topoisomerase II in Postnatal Rat Testis
(Indian Institute of Science, 2005-11-23)Characterization of the polyoma virus chromosome as a circular, double-stranded, supercoiled DNA (Weil and Vinograd, 1963; Vinograd et al.,-1965) made it apparent that the DNA enzymatic machinery faces a formidable problem ... -
Developmental and Functional Roles of Troponin-T Isoforms, and Exploring Genome-Wide Alterations in Drosophila Indirect Flight Muscle Mutants
(2018-05-23)Muscle contraction is a highly fine-tuned process that requires the precise and timely construction of large protein sub-assemblies to form sarcomeres, the individual contractile units. Mutations in many of the genes ... -
Developmental Basis and Diversity of Polar Growth Patterns in Leaves
(2018-03-06)Growth polarity in leaves – a final discussion Insights into the growth processes of leaf lamina have come from studies on several species including Arabidopsis, Antirrhinum, tobacco and maize. A feature common to the ... -
Diaminopropionate Ammonia Lyase : Characterization, Unfolding And Mechanism Of Inhibition By Aminooxy Compounds
(2009-03-13)Diaminopropionate ammonia lyase (DAPAL) which belongs to the class of PLP enzymes is reported only from prokaryotes. It is involved in the removal of two amino groups from its substrate, diaminopropionate, to form ammonia ... -
Differential DNA methylation patterns in primary and recurrent glioblastomas : Protumorigenic roles of Tumor Endothelial Marker 8 (TEM8) and ASAP1 genes
Glioblastomas (GBMs) are clinically aggressive malignant brain tumors in adults with a median survival of 14 months on diagnosis. Therapeutic interventions such as debulking surgeries, chemotherapy, and ionizing radiation, ... -
Differential Regulation of Calcium Dependent Phase Separation and Modular Assembly of Sap97/Hdlg Enriched Molecular Complexes
Recent studies over a few decades have changed the perspective of the molecular architecture of functional zones within synapses and other cell junctions. Observations in the last decade confirm Post Synaptic Density as ... -
Differential Regulation Of tRNA1 Gly Genes In Bombyx Mori
(2012-03-30) -
Dispersal Patterns and Processes in Littorinid Snails along the Indian Coastline
Dispersal has important ecological and evolutionary consequences for a species. Marine dispersal is unique because of facilitation by ocean currents, where oceanography interacts with species traits and environmental ... -
Dissecting the C-DI-GMP Signaling Pathways : Tools and Tales
(2018-02-27)Evaluating aerodynamic noise from aircraft engines is a design stage process, so that it conform to regulations at airports. Aerodynamic noise is also a principal source of structural vibration and internal noise in ... -
Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells
In animal cells, the duplicated genetic material is aligned on a microtubule-based structure known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, and the sister chromatids get ... -
Dissecting the role of Ataxin 2 Binding Protein 1 in sarcomeric protein stoichiometry and generation of muscle diversity in Drosophila melanogaster
Drosophila muscles are an excellent model to study muscle development, diversity and function. Drosophila muscles consist of two major types –1. Indirect Flight Muscles (IFM), that are fibrillar; as opposed to other tubular ... -
Dissecting the Role of Calcium Binding Proteins in Muscle using Drosophila Indirect Flight Muscles as the Model System
Muscle development and function are highly synchronized processes that involve simultaneous action of several transcription factors, signalling cascades, kinases and phosphatases, ion channels, structural proteins and ... -
Distribution, activity budget and feeding ecology of Himalayan gray langur (Semnopithecus ajax) in Kashmir Himalaya
Colobines are group of primates known to inhabit harsh environments. These habitats pose different challenges which they have coped up physiologically and behaviourally. Primates in such environments are subjected to ... -
The Distribution, Dynamics & Impacts Of Invasive Lantana Camara In A Seasonal Forest Of Mudumalai, Southern India
(2016-04-25)Species that become naturalized in a new geographical range, subsequently multiply and spread, and persist to the detriment of resident communities, are known as alien invasive species. Two aspects of species invasion – ... -
Diversity and distribution of mixed-species foraging groups in the Lakshadweep Islands, India
Species interactions are known to shape biological communities. While antagonistic interactions like competition and predation are well known, cooperative interactions have received comparatively less attention. Mixed-species ...