Browsing Division of Biological Sciences by Title
Now showing items 141-160 of 1514
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Computational Analyses of Protein Structure and Immunogen Design
(2018-08-20)The sequence of a polypeptide chain determines its structure which in turns determines its function. A protein is stabilized by multiple forces; hydrophobic interaction, electrostatic interactions and hydrogen bond formation ... -
Computational Analyses Of Proteins Encoded In Genomes Of Pathogenic Organisms : Inferences On Structures, Functions And Interactions
(2015-02-04)The availability of completely sequenced genomes for a number of organisms provides an opportunity to understand the molecular basis of physiology, metabolism, regulation and evolution of these organisms. Significant ... -
Computational And Biochemical Studies On The Enzymes Of Type II Fatty Acid Biosynthesis Pathway : Towards Antimalarial And Antibacterial Drug Discovery
(2009-08-13)Malaria, caused by the parasite Plasmodium, continues to exact high global morbidity and mortality rate next only to tuberculosis. It causes 300-500 million clinical infections out of which more than a million people succumb ... -
Computational and Experimental Approaches to Protein Design
Protein design is a rapidly maturing field, with the goal of designing proteins with customized structures and functions. A large number of protein structures are experimentally determined, which have facilitated an ... -
Computational And Experimental Studies On Protein Structure, Stability And Dynamics
(2014-08-18)The work in this thesis focuses on the study of three main aspects of proteins, viz, Protein structure, stability, and dynamics. Chapter 1 is a general introduction to the topics studied in this thesis. Chapter 2 deals ... -
Computational Investigation of Heterogeneous Lateral Organisation in Biological Membrane
The study of lateral heterogeneity on membrane surface has come a long way from the fluid mosaic model. Simulations and experimental studies have observed non-random mixing of lipids and proteins in the membrane. In this ... -
Computational investigation of peripheral membrane protein "Pleckstrin homology domain" and its regulation
The peripheral membrane protein repertoire is around 25% composed of the Pleckstrin homology domain (PHD). PHD are component of the multidomain protein and plays the role of an adaptor in recruitment of these proteins ... -
Computational mechanisms underlying eye-head coordination
Gaze or eye-head coordination is an ethologically and physiologically important process that directs the visual system to objects of interest. Due to its relative simplicity, it is an ideal system to study multi-effector ... -
Computational Mechanisms Underlying the Voluntary Control of Reach Movement Planning and Execution
In everyday life we make a variety of reaching movements. Most of these reaching movements have a clear objective of bringing the hand to the spatial location of the object of interest. Although we typically do not explicitly ... -
Computational studies on interacting proteins with special reference to toxin-antitoxin systems
Proteins interact with other proteins to maintain functional homeostasis of the cell by tightly regulating cellular processes. Hence, it becomes important to understand not only the downstream effects of protein-protein ... -
Computer Modeling and Molecular Dynamics Simulation Of Angiogenins And Its Ligand Bound Complexes
(Indian Institute of Science, 2006-05-04)Computational structural biology Even with rapid advances in structure determination methods, there is a long gap to be bridged between the number of proteins that have been sequenced and the number whose three-dimensional ... -
Computer modelling approach to study the mode of binding of flavins to flavodoxin
Abstract not available -
Computer Modelling Studies On DNA Triple Helices
(2013-07-22) -
Computer modelling studies on guanine-rich quadruplexes
On the basis of these MD studies, it can be concluded that parallel G-quadruplexes are very stable structures, both energetically as well as structurally. Base interaction energy within the G-tetrad, as well as guanine ... -
concanavalin A- Carbohydrate interactions: a computer modelling approach
Lectins are cell-agglutinating, carbohydrate-binding proteins. They began to generate interest when it was discovered in the 1940s that some of them were capable of specifically agglutinating human erythrocytes. Most lectins ... -
Condition-dependent signalling and mating behaviour in the tree cricket, Oecanthus henryi
Male reproductive success in systems exhibiting sexually selected traits can be driven by male mating effort in sexual signals and in the production of nuptial gifts. Male mating effort can be determined by various biotic ... -
Conformation of calcium antagonists and their interaction with model membranes
Calcium antagonists are a class of drugs with diverse chemical identities and a wide range of pharmacological activities. At least four different chemical classes can be identified within this group of drugs. This heterogeneity ... -
Conformation of peptidoglycan and mode of penicillin action
Penicillins and cephalosporins are conformationally similar to D-L-Ala-D-Ala due to the presence of the lactam ring. The mode of binding of the aminoacyl group of penicillin and cephalosporin with transpeptidase is the ... -
CONFORMATION OF POLYNUCLEOTIDES
The conformations of the five?membered rings and other relevant conformational features of deoxyribose, ribose, and arabinose have been analysed in this chapter and in the preceding two chapters. The analysis included ...