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    Determination of significance of SUMOylation of the Smc5/6 complex 

    Balagopal, Deepa
    The fascination of scientists to the Smc5/6 complex began in the 1990s, with the characterization of UV and γ radiation-sensitive rad18 mutant and its identification as a component of a novel Structural Maintenance of ...

    Biochemical characterization of UvrD helicase and its 1 interplay with DNA mismatch repair proteins in 2 Neisseria gonorrhoeae 

    Ganguli, Debayan
    UvrD helicase belongs to type I superfamily of helicases. It participates in Nucleotide Excision Repair (NER) and DNA Mismatch Repair (MMR). It also participates in the rolling circle replication. It has been shown that ...

    Investigation of RAG1 in lymphoid and brain cells: Understanding mechanism and regulation 

    Nilavar, Namrata M
    In summary, we show that RAG1 expression is regulated through a novel miRNA (miR- 29c) mediated mechanism and establish that as an additional mode of RAG1 regulation. Studies described in the thesis reveal that among the ...

    Mechanistic insights into the replication of Sesbania mosaic virus 

    Bakshi, Arindam
    The present thesis deals with the mechanism of replication of Sesbania mosaic virus (SeMV), which belongs to the genus sobemoviruses. Sobemoviruses are single stranded positive sense RNA viruses which infect both mono and ...

    Understanding mRNA fate regulation by RGG motif protein, Sbp1 

    Bhatter, Nupur
    Cellular events that rely on translation regulation has been well established, however the molecular details of factors involved in bringing translation control remains inadequately explored. RNA binding proteins form ...

    Uncovering of a novel non-taxane anticancer secondary metabolite from Taxol-producing endophytic fungus: Optimization of culture parameters and whole-genome sequence analysis for improved taxane production biosynthesis. 

    Singh, Satpal
    Cancer-related mortalities and morbidities have proven to be a great health burden for human society with immense economic implications. With uncontrolled proliferation of cells as the fundamental principle underlying its ...

    Molecular and biochemical studies on components of transcription regulation, tropane alkaloid biosynthesis and signal transduction in the medicinal plant Datura metel L. 

    Rajvanshi, Pradumn K
    Tropane alkaloids (TA) are among the oldest medicines known to humankind as they possess hallucinogenic and poisonous properties. Datura metel, an herbaceous plant, belongs to the family Solanaceae whose members are well ...

    Role of mammalian RAD51 paralogs in replication stress response and genome maintenance 

    Saxena, Sneha
    The focus of my research has been to understand the molecular mechanisms underlying the role of mammalian RAD51 paralogs in genome maintenance and tumor suppression. The investigation carried out during this study has ...

    Regulation of carbon metabolism in Pichia pastoris by Mxr1p and identification of novel regulators 

    Gupta, Aditi
    Pichia pastoris (a.k.a. Komagataella phaffii), a widely used yeast for recombinant protein production, is cultured under a variety of conditions ranging from shake flasks to large bioreactors employing minimal, chemically ...

    Development and Characterization of a potent Tumor Necrosis Factor-alpha blocking agent 

    Jameei, Aida
    Tumor necrosis factor-α (TNFα), one of the major pro-inflammatory cytokines, plays a pivotal role in an effective inflammation process and immune response. TNFα interacts with two different receptors, TNFR1 and TNFR2, which ...
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    AuthorBakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)Chakraborty, Subhashish (1)Dey, Trishna (1)Ganguli, Debayan (1)... View MoreSubjectNATURAL SCIENCES (38)Cancer (3)Mitochondria (3)DNA double-strand breaks (2)Helicobacter pylori (2)Pichia pastoris (2)SUMOylation (2)Taxol (2)Abrin (1)Acetylation (1)... View MoreHas File(s)Yes (38)

    etd@IISc is a joint service of SERC & J R D Tata Memorial (JRDTML) Library || Powered by DSpace software || DuraSpace
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