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    Metabolic and Pharmacological Modulations During IFN-γ signaling 

    Chattopadhyay, Avik
    Interferons, initially discovered for their antiviral properties, play pivotal roles in various biological processes, including host defense against pathogens, tumor surveillance, and disease pathogenesis. Interferon-gamma ...

    Understanding the architecture of mitochondrial presequence translocase machinery and its implications in ALS progression 

    Waingankar, Tejashree Pradip
    The current thesis describes the structural organization of the presequence translocase machinery and its functional association with ALS pathogenesis. The TIM23 complex is essential for the mitochondrial biogenesis of ...

    Understanding the adaptive responses of Salmonella Typhimurium during bile stress 

    Singh, Madhulika
    Salmonella Typhimurium (S. Typhimurium) is an enteric pathogen that causes gastroenteritis. Although gastroenteritis is usually non-life threatening in healthy adults, it can cause fatality in children and immunocompromised ...

    Deciphering the biochemical and biophysical properties of the Holliday junction resolvases RuvC and RuvX from Mycobacterium smegmatis 

    Agarwal, Ankit
    Homologous recombination (HR) is a ubiquitous cellular process that occurs in all three domains of life as well as in DNA and RNA viruses. In eukaryotes, HR is critically important for homology-directed DNA repair (HDDR) ...

    Understanding the role of DNAJC30 and ISCU in mitochondrial homeostasis 

    Birje, Abhijit
    Williams-Beuren Syndrome (WBS) is a rare multisystem genomic disorder characterized by mild to moderate cognitive impairment, unique personality traits, distinctive facial features, cardiovascular problems, and infantile ...

    Translation in the 3'Untranslated Region of Mammalian Transcripts 

    Kar, Debaleena
    Mammalian mRNAs generally have a 5'UTR (untranslated region), a coding DNA sequence, and a 3'UTR. The 3'UTR of mRNA is generally believed to be the untranslated region of the mRNA. However, there are certain instances ...

    In vivo mechanistic insights into the trans-splicing based expression of Hsp90 in Giardia lamblia 

    Tushir, Sheetal
    Giardia lamblia, a simple yet intriguing protozoan parasite, challenges conventional paradigms in gene expression through its unique mechanism of trans-splicing for Heat Shock Protein 90 (Hsp90). As a primitive organism, ...

    A Ligase IV/XRCC4-dependent single strand break repair pathway for the maintenance of A/T-rich regions during DNA replication in mammals 

    kumari, Nitu
    The DNA in our cells is under constant threat from various exogenous and endogenous sources. To ensure error free and faithful transmission of hereditary material, human cells employ several DNA repair pathways. Mammalian ...

    The Nse1p RING domain is required for maintaining transcriptional silencing and genomic organization in Saccharomyces cerevisiae 

    Maharshi, Neelam
    Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ...

    Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species 

    Taritla, Sidhartha
    Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...
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    AuthorAgarwal, Ankit (1)Akhtar, Md Noor (1)Bakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)Birje, Abhijit (1)... View MoreSubjectNATURAL SCIENCES (59)Cancer (5)Mitochondria (5)Chromatin (2)DNA double-strand breaks (2)DNA repair (2)Giardia lamblia (2)Helicobacter pylori (2)Holliday junction (2)Homologous recombination (2)... View MoreHas File(s)Yes (58)No (1)

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