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    Identification and Biochemical Characterization of Novel Inhibitors of Nonhomologous End Joining: Implications in DNA Double-Strand Break Repair and Cancer Therapy 

    Ray, Ujjayinee
    To summarize, in the present study, we have synthesized and characterized three novel NHEJ inhibitors targeting DNA Ligase IV, with several fold better efficacy compared to SCR7 and thus potential to be developed as cancer ...

    Insights into the Differential Cytotoxicity of Abrin and Design of a Vaccine Candidate against the Toxin 

    Tiwari, Vinita
    Ribosome inactivating proteins (RIPs) from plants, fungi or bacteria are extremely lethal due to their N-glycosidase activity on eukaryotic ribosomal RNA. As the name indicates, these toxins inactivate ribosomes; thereby ...

    Non-canonical functions of lymphoid-specific proteins AID and RAG1: Understanding mechanism, regulation, and implications in genomic instability 

    Roy, Urbi
    Recombination-activating genes (RAGs) and Activation-induced cytidine deaminase (AID) are lymphoid cell-specific proteins that play crucial roles in the development of adaptive immunity. Diversification of the immune system ...

    Flavivirus RNA replication: Probe development, structural dynamics, and role of zinc ions. 

    Srinivasa, Ramya
    Flaviviruses share a typical genome architecture where the highly conserved UTRs flank a central coding region. They also share a common genome replication strategy called genome cyclization where the UTRs interact to form ...

    Insights into life-cycle stage transition of Trichomonas vaginalis and advancement in its diagnosis 

    Yadav, Priya
    Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ...

    Deciphering Hypoxic Adaptations in Cutibacterium acnes using Multi-omics Profiling and Systems Modelling 

    Pandia, Bandana
    The opportunistic skin anaerobe Cutibacterium acnes (C. acnes) contributes to skin homeostasis with its antioxidant and immunomodulatory activities. C. acnes (formerly known as Propionibacterium acnes) is an aerotolerant, ...

    Metabolic Regulation of Gametocytogenesis in Malaria 

    Beri, Divya
    Plasmodium sp. is an obligate intracellular protozoan parasite causing malaria and is responsible for more than 500,000 human deaths annually. P. falciparum and P. vivax are the two major species causing malaria in humans. ...

    Systems biology approach to dissect Salmonella-host interactions 

    Banerjee, Pip
    Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ...

    Exploring the role of low complexity protein sequence in regulating RNA granule dynamics and translation control 

    Roy, Raju
    RNA granules are conserved membraneless mRNP complexes that play an important role in determining mRNA fate by affecting translation repression and mRNA decay. Processing bodies (P-bodies) harbor enzymes responsible for ...

    Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression 

    Vishwanathan, Vinaya
    Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ...
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    AuthorAgarwal, Ankit (1)Akhtar, Md Noor (1)Bakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)Birje, Abhijit (1)... View MoreSubjectNATURAL SCIENCES (59)Cancer (5)Mitochondria (5)Chromatin (2)DNA double-strand breaks (2)DNA repair (2)Giardia lamblia (2)Helicobacter pylori (2)Holliday junction (2)Homologous recombination (2)... View MoreHas File(s)Yes (58)No (1)

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