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    The Nse1p RING domain is required for maintaining transcriptional silencing and genomic organization in Saccharomyces cerevisiae 

    Maharshi, Neelam
    Chromatin is a dynamic structure that reorganizes to support proper transcription, replication, repair, and segregation. Principal chromosomal constituents that shape chromosomes are the SMC (Structural Maintenance of ...

    Isolation, structure elucidation and increasing anticancer efficacy of an anti-cancer secondary metabolite from a marine-derived endophytic fungus, Aspergillus species 

    Taritla, Sidhartha
    Cancer is the leading cause of mortality globally, contributing to ~10 million fatalities in 2020, or roughly one in every six deaths, according to global cancer statistics 2020. Around 50% of all small molecules approved ...

    Metabolic Regulation of Gametocytogenesis in Malaria 

    Beri, Divya
    Plasmodium sp. is an obligate intracellular protozoan parasite causing malaria and is responsible for more than 500,000 human deaths annually. P. falciparum and P. vivax are the two major species causing malaria in humans. ...

    Systems biology approach to dissect Salmonella-host interactions 

    Banerjee, Pip
    Systems understanding of the biological data is required to capture the complex biochemical information when a pathogen interacts with its host. Such interactions are dynamic and complex, especially because various components ...

    Exploring the role of low complexity protein sequence in regulating RNA granule dynamics and translation control 

    Roy, Raju
    RNA granules are conserved membraneless mRNP complexes that play an important role in determining mRNA fate by affecting translation repression and mRNA decay. Processing bodies (P-bodies) harbor enzymes responsible for ...

    Understanding the role of mtHsp70 in regulating mitochondrial homeostasis: revealing its significance in Congenital Sideroblastic Anemia progression 

    Vishwanathan, Vinaya
    Mitochondria are ubiquitous organelles placed at the nexus of several metabolic and signaling pathways essential for cell survival. Therefore, maintaining a healthy and functional organelle becomes paramount for the cell. ...

    Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity 

    Bhattacharya, Supreet
    Substrate interrogation of the CRISPR-Cas12a endonuclease reveals an unexpected functional plasticity Currently, Cas9 and Cas12a (also known as Cpf1) are the sole members of a large family of RNA-guided nucleases that ...

    Non-canonical functions of lymphoid-specific proteins AID and RAG1: Understanding mechanism, regulation, and implications in genomic instability 

    Roy, Urbi
    Recombination-activating genes (RAGs) and Activation-induced cytidine deaminase (AID) are lymphoid cell-specific proteins that play crucial roles in the development of adaptive immunity. Diversification of the immune system ...

    Flavivirus RNA replication: Probe development, structural dynamics, and role of zinc ions. 

    Srinivasa, Ramya
    Flaviviruses share a typical genome architecture where the highly conserved UTRs flank a central coding region. They also share a common genome replication strategy called genome cyclization where the UTRs interact to form ...

    Insights into life-cycle stage transition of Trichomonas vaginalis and advancement in its diagnosis 

    Yadav, Priya
    Trichomonas vaginalis is a protozoan parasite and the causative agent of the most common non-viral, sexually transmitted disease (STD) in humans known as trichomoniasis. WHO estimates more than 270 million cases of ...
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    AuthorAgarwal, Ankit (1)Akhtar, Md Noor (1)Bakshi, Arindam (1)Balagopal, Deepa (1)Banerjee, Pip (1)Banerjee, Ushashi (1)Beri, Divya (1)Bhattacharya, Supreet (1)Bhatter, Nupur (1)Birje, Abhijit (1)... View MoreSubjectNATURAL SCIENCES (59)Cancer (5)Mitochondria (5)Chromatin (2)DNA double-strand breaks (2)DNA repair (2)Giardia lamblia (2)Helicobacter pylori (2)Holliday junction (2)Homologous recombination (2)... View MoreHas File(s)Yes (58)No (1)

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