Browsing Microbiology and Cell Biology (MCB) by Title
Now showing items 217-236 of 239
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Ultrastructural and Molecular Analyses of the Unique Features of Cell Division in Mycobacterium Tuberculosis and Mycobacterium Smegmatis
(2018-04-13)The Mycobacterium genus contains major human pathogens, like Mycobacterium tuberculosis and Mycobacterium leprae, which are the causative agents of Tuberculosis and Leprosy, respectively. They have evolved as successful ... -
Understanding Functions for Fission Yeast Pre-mRNA Splicing Factors SpPrp18 and SpSlu7 in Constitutive and Alternative Splicing
(2017-11-29)Exonic sequences of eukaryotic genes are interspersed with introns which when accurately removed from the primary transcript (pre-mRNA) results in a functional transcript. These splicing reactions are carried out by the ... -
Understanding Phage MU Mom Regulation and Function
(2018-06-11)Mu is a temperate bacteriophage which infects Escherichia coli and several other Gram negative enteric bacteria. It is an extraordinary phage in several respects and has carved a special niche for itself both as a genetic ... -
Understanding the Functions of Nucleoid Associated Proteins in Mycobacterium tuberculosis
The prokaryotic genome, though lacks a membrane bound organelle for its housing, is restricted to only about 25% of the cytoplasmic space called the nucleoid. The dramatic compaction required for the genome to fit in is ... -
Understanding the mechanism of host deacetylase SIRT1 and SIRT3 in the modulation of Salmonella pathogenesis
Host sirtuins are one of the important modulators of host immuno-metabolic regulation. However, the role of sirtuins in the modulation of the immune metabolism pertaining to Salmonellosis is largely unknown. Here, we ... -
Understanding the mechanisms of polarity establishment and nuclear envelope breakdown in Caenorhabditis elegans embryos
Polarity establishment is critical for the development and stem cell lineages. The one-cell stage of the Caenorhabditis elegans embryo polarizes soon after fertilization. As a result, the first division of the embryo ... -
Understanding the redox homeostatic mechanisms in Mycobacterium tuberculosis infection
Mycobacterium tuberculosis (Mtb) is an obligate intra-cellular pathogen that causes the disease tuberculosis (TB) in its human hosts. An estimated 1% of the world population is reported to get infected with the disease ... -
Understanding the regulation of translation and replication of Coxsackievirus B3 RNA by host RNA binding proteins
Coxsackievirus B3 (CVB3) is an enterovirus, with a positive-sense single-stranded RNA genome. The genome contains a single open reading frame (ORF) flanked by untranslated regions (UTR) at the 5’ and 3’ ends. The viral ... -
Understanding the role of Cysteine desulfurases in Mycobacterium tuberculosis physiology and pathogenesis
The Mycobacterium tuberculosis (Mtb) persistence inside the human host relies on successful adaptation to host-induced stresses such as reactive oxygen species (ROS), reactive nitrogen species (RNS), iron starvation, low ... -
Understanding the role of paraspeckle components NEAT1 and PSPC1 in HCV life cycle and pathogenesis
Hepatitis C virus (HCV) is an enveloped, small, icosahedral, positive-sense single-stranded RNA virus that belongs to the Hepacivirus genus and the Flaviviridae family. HCV causes acute and chronic hepatitis which can range ... -
Understanding the Role of Rab22A in Recycling Endosome Biogenesis and Melanocyte Pigmentation
(2018-08-28)Recycling embosoms (REs) are transient intermediates of endosomal network, constantly generated from early/sorting endosomes (EEs/SEs). Conventionally, these organelles function in recycling of many growth/nutrient/signalling ... -
Understanding the Role of SIRT2 in Cardiac Hypertrophy, Cell Death and Glucose Homeostasis
Over the last century the major causes of human deaths and ailments has shifted from acute infectious diseases to chronic aging related disorders like cancer and type-2 diabetes. The aging process is a universal property ... -
Understanding the Role of ZCF32, a Zinc Cluster Transcription Factor, in Candida albicans Biology
(2018-05-25)As a human fungal pathogen, Candida albicans can cause a wide variety of disease conditions ranging from superficial to systemic infections. Many of these infections are caused by an inherent ability of the pathogen to ... -
Understanding the Significance of Ydcp, a Putative Peptidase Encoding Gene, in Virulence of Salmonella
Salmonella is a recognised enteric pathogen which infects several mammalian and avian hosts through faeco-oral route and establishes either a localised gastrointestinal inflammation and diarrhoea or a systemic fever, ... -
Understanding the SNARE Dynamics During Melanosome Biogenesis
(2018-08-11)Melanosome biogenesis is a highly regulated endosomal maturation process wherein structural fibers harbouring immature melanosomes acquires its biosynthetic proteins through the secretory pathway and finally matures into ... -
Unique Response and the Survival Mechanism of Mycobacterial Subpopulations against Oxidative and Nitrite Stress
(2017-12-03)Mycobacterial populations are known for the heterogeneity in terms of cell size, morphology, and metabolic status, which are believed to help the population survive under stress conditions. Such population heterogeneity ... -
Unraveling the multifaceted interactions between the tumor cell hierarchy and the stroma: Implications on tumor growth
In this study, we have functionally characterized the roles of SEZ6, a GSC-specific protein, and FMOD, a DGC-specific protein, in inducing tumor angiogenesis. Angiogenesis being a crucial requirement for both tumor initiation ... -
Unraveling the role of cellular phosphatases in lysosome function and storage diseases
Eukaryotic cellular pathways are maintained and coordinated through biomolecule turnover, which includes synthesis, trafficking, degradation of cellular components and their reutilization. The process of biomolecule ... -
Unravelling the functional role of Arf-like GTPases 14 and 15 in mammalian cells
Small G-proteins of Arf-like (Arl) GTPase subfamily are shown to regulate several cellular processes including intracellular trafficking, cytoskeletal organization, organelle biogenesis, cell adhesion and migration. Around ... -
Unravelling the Mechanism of Bactericidal/Permeability-Increasing Protein Expression during Bacterial Pathogenesis
(2018-02-21)Anti-microbial proteins (AMP) are the key effector arm of the innate immune system. The prevalence of AMP in single-celled eukaryotes to humans shows its importance during the course of evolution. The first report for the ...