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    Browsing Microbiology and Cell Biology (MCB) by Title

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      • Deciphering canonical and non-canonical role of splicing factor Prp16 in pathogenic yeast C. neoformans 

        Negi, Manendra Singh
        RNA splicing is a ubiquitous process during eukaryotic gene expression, where non-coding introns are removed from primary transcripts to form functional mRNA. This vital process is carried out by the spliceosome, a large ...
      • Deciphering Functions & Interactions of Fission Yeast Splicing Factor SpSlu7 Relevant to Constitutive & Alternative Splicing 

        Sen, Titash
        The fission yeast genome with abundant multi-intronic transcripts, degenerate splice signals and presence of alternative splicing machinery is an attractive unicellular fungal model to investigate splice-site recognition ...
      • Deciphering the mechanism behind the division of the Salmonella containing vacuole (SCV) and the immunomodulation strategy employed by Salmonella Typhimurium 

        Chopra, Umesh
        The genus Salmonella represents flagellated, Gram-negative, rod-shaped anaerobic bacteria which is a leading cause of food-borne illness and causes enteric disease in a wide range of animals. In humans and several warm-blooded ...
      • Deciphering the mechanisms employed by Salmonella to mediate modulation of host endo-lysosomal machinery 

        Chatterjee, Ritika
        Salmonella genus encompasses Gram-negative, rod-shaped, facultative anaerobic, non-sporulating, and predominantly motile enteric bacteria. It causes pathogenesis in a wide array of hosts, from cold-blooded animals to humans ...
      • Deciphering the role of host protein HuR in RNA virus life cycle and pathogenesis: Hepatitis C Virus and SARS-CoV-2 as exemplars. 

        Raheja, Harsha
        Viruses pose a major threat to human health and the ongoing SARS-CoV-2 pandemic proves as the best evidence for that. Historically, RNA viruses have a major potential to cause such pandemics. They utilise RNA binding ...
      • Deciphering the Role of METTL3-Dependent m6A-epitranscriptome in Glioma Stem-like Cells 

        Visvanathan, Abhirami
        The major roadblocks in treatment for GBM are resistance to therapy and recurrence of GBM cells. Regardless of various treatment strategies, the average survival of GBM patients is poor and incidence of recurrence remains ...
      • Deciphering the role of outer membrane porins in the pathogenesis of Salmonella enterica serovar Typhimurium 

        Roy Chowdhury, Atish
        Porins are highly conserved barrel-shaped proteins bound to the bacterial outer membrane and involved in the selective transport of charged molecules across the membrane. They consist of parallel and anti-parallel β sheets ...
      • Deciphering the role of spermidine in Salmonella Typhimurium pathogenesis 

        Vijay Nair, Abhilash
        Salmonella enterica serovar Typhimurium (S. Typhimurium) is a Gram-negative, facultative anaerobic bacterium. It infects a broad range of hosts, causing symptoms such as gastroenteritis, abdominal pain, inflammatory diarrhoea ...
      • Decoding Epigenetic Regulators in Cancer: Acetylation of HIF2A by Histone Acetyltransferase 1 (HAT1) is essential for executing hypoxia response in glioma 

        Kumar, Naveen
        Gliomas are tumors of the central nervous system arising from glial cells. Based on the origin of the cell type, it can be astrocytoma, oligodendroglioma, and ependymoma. Astrocytoma is the most common type of glioma, ...
      • Delineating the Role of OsMADS1 in Auxin Distribution, Floret Identity and Floret Meristem Determinacy 

        Lhaineikim, Grace (2017-12-02)
        Rice have highly derived florets borne on a short branch called ‘spikelet’ comprised of a pair of rudimentary glumes and sterile lemma (empty glumes) that subtends a single fertile floret. The floral organs consist of a ...
      • Delineating the Roles for WNT Signaling During PRRs Driven Inflammatory Responses : Implications for Host-Pathogen Interaction 

        Singh, Vikas
        The mammalian immune system consists of the innate and adaptive arm/s that protect the host against pathogenic infections in a highly coordinated process involving multiple steps. Innate immune cells such as macrophages ...
      • Delineation Of Signal Transduction Events During The Induction Of SOCS3 By Mycobacterium Bovis BCG : Possible Implications For Immune Subversion Mechanisms 

        Yeddula, Narayana (2010-09-30)
        Pathogenic Mycobacteria are among the most unrelenting pathogens known to mankind as one-third of the world population is latently infected with Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis. ...
      • Delineation Of Signaling Events Regulating Mycobacterium Bovis BCG Induced Expression Of MMR-9 And SPI6 : Possible Implications For Immune Subversion Mechanisms 

        Kapoor, Nisha (2013-08-30)
        One key to the pathogenic potential of the mycobacteria lies in their capacity to resist destruction by infected macrophages and dendritic cells. Robust host immune responses during mycobacterial infection often involve a ...
      • Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe 

        Nagampalli, Vijay Krishna (2018-05-10)
        Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene ...
      • Developmental Basis and Diversity of Polar Growth Patterns in Leaves 

        Gupta, Mainak Das (2018-03-06)
        Growth polarity in leaves – a final discussion Insights into the growth processes of leaf lamina have come from studies on several species including Arabidopsis, Antirrhinum, tobacco and maize. A feature common to the ...
      • Differential Expression Of tRNA1 Gly Genes From Within A Multigene Family In Bombyx Mori 

        Parthasarthy, Akhila (2013-08-20)
      • Differential Regulations Of p73 By Viral Oncogenes And Its Implications For Therapeutics 

        Sanjeev Das, * (2011-05-05)
      • Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells 

        Rajeevan, Ashwathi
        In animal cells, the duplicated genetic material is aligned on a microtubule-based structure known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, and the sister chromatids get ...
      • Diversity In Indian Equine Rotaviruses And Structure And Function Of Rotavirus Non Structural Protein 4 (NSP4) 

        Deepa, R (2009-03-11)
        Rotaviruses, members of the family Reoviridae, are the major etiologic agents of severe, acute dehydrating diarrhea in the young of many mammalian species, including humans, calves and foals. Recent estimates indicate an ...
      • Division of the Salmonella Containing Vacuole and Other Virulence Strategies Employed by Salmonella 

        Chaudhuri, Debalina
        Salmonella comprises a genus of rod-shaped, Gram-negative, non-sporulating and primarily motile enterobacteria. They have remained a major cause of morbidity and mortality worldwide, claiming several hundreds of lives per ...

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