Browsing Microbiology and Cell Biology (MCB) by Title
Now showing items 150-169 of 292
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Mutational analysis of Rpb4 and Rpb7 : Insights into their role in transcription and stress response of saccharomyces cerevisiae
The Yeast Saccharomyces cerevisiae as a Model System for Stress Response and Transcription The yeast Saccharomyces cerevisiae is an excellent model system to study the molecular basis of stress response. Apart from its ... -
Mycobacterial topoisomerases: insights into structure, mechanism and function
DNA encounters topological constraints during essential cellular processes such as replication, transcription, and chromosome segregation. To ensure facile execution of these processes, a ubiquitous class of enzymes known ... -
Mycobacterium smegmatis topoisomerase I : insights into site specific recognition and mechanism of action
Mycobacterium smegmatis TOPOISOMERASE I: INSIGHTS INTO SITE-SPECIFIC RECOGNITION AND MECHANISM OF ACTION The work embodied in this thesis is an attempt to understand the relaxation mechanism catalyzed by Mycobacterium ... -
New Active Site Fold And The Role Of Metal Ions In Structure Function Relationship Of A Promiscuous Endonuclease - R.KpnI
(2010-07-08)Bacteria employ survival strategies to protect themselves against foreign invaders, including bacteriophages. The ‘immune system’ of bacteria relies mostly on restriction-modification (R-M) systems. The primary role of R-M ... -
Notch1-Induced Survival Signaling And Its Implications In Cancer Therapeutics
(2009-04-15)Notch receptors and ligands are type I transmembrane proteins that regulate development and differentiation during cell-cell contact. There are four Notch receptor homologues and five notch ligands, identified in humans ... -
Nucleoid-associated Proteins of Mycobacterium tuberculosis : Insights into their Functions
Bacteria face the challenging task of compacting their chromosomes to accommodate them in a small cytoplasmic volume and at the same time maintaining the nucleoids in a highly organized and dynamic state for transcription, ... -
Panoramic View of RNA Binding Proteins (RBPs) in Glioblastoma : IMP3, an RBP, is Essential for Glioma Stem-like Cell Maintenance
Gliomas are primary brain tumors in adults that are believed to originate from different types of glial cells. Central nervous system gliomas pose particularly difficult problems because of their tendency towards malignancy, ... -
Phosphoprotein P of rinderpest virus : Its role in the virus life cycle
Phosphoprotein P of Rinderpest Virus: A Key Player in the Virus Life Cycle Introduction Negative-strand RNA viruses (NNSVs) are enveloped viruses infecting hosts across the animal and plant kingdoms. They exhibit diverse ... -
Physiological Importance Of DNA Repair In Mycobacteria
(2013-01-16) -
Physiological Role of Arr, an ADP-ribosyltransferase in Mycobacterium smegmatis
The studies reported in this thesis address the physiological role of an antibiotic resistance gene arr, followed by establishment of the arr knockout strains (generated during the investigation) for drug testing and ... -
Physiological Role of Folate Dehydrogenase in One Carbon Metabolism of Escherichia Coli
(2018-06-08)Thesis addresses the physiological role of formyl tetrahydrofolate synthetase (Fhs) and bifunctional folate dehydrogenase (FolD) in folate mediated one carbon metabolism in bacteria. Thesis consists of 5 chapters. First ... -
Physiological significance of tRNA sequences and modifications in regulation of the bacterial growth
Transfer RNA or tRNA is one of the vital components of translation machinery where it acts as an adaptor molecule to bring amino acid to the ribosome in response to the genetic code in mRNA. Its key role is to decode the ... -
Post translational modification and DNA binding studies with two nucleoid associated proteins of Mycobacterium tuberculosis
Genome in prokaryotes is found in a small confinement called nucleoid. The nucleoid compaction is brought about by the combined action of topoisomerases and Nucleoid associated proteins (NAPs). Topoisomerases maintain ... -
PP2A-phosphatase and Polo-like kinase 1 regulates spindle positioning by orchestrating the cortical levels of the dynein adaptor NuMA
The mitotic spindle is a microtubule-based diamond shape structure that captures chromosomes and facilitates their segregation during anaphase. Proper positioning of the mitotic spindle is critical for defining the ... -
Probing the Splicing and Enzymatic Function of Fission Yeast Prp16 – A DEAD Box RNA Helicase
Nuclear pre-mRNA splicing occurs at precisely conserved sequence elements at and around the splice sites which result in ligation of exons and release of intron as lariat. The Schizosaccharomyces pombe genome is an apt ... -
Production of aromatic alcohols and hydroxy acids by candida species and the mode of action of aromatic alcohols
The thesis entitled “Alcohols and Hydroxy Acids by Candida Species and Their Mode of Action”, submitted by Mr. T. K. Narayanan for the Ph.D. degree of the Indian Institute of Science, Bangalore–560012, India. Yeasts, in ...